Skip to main content
SpringerLink
Log in

Heterotransplantation of human malignant tumours to athymic nude mice

  • Chapter
Immunodeficient Animals for Cancer Research

Abstract

Almost 10 years have past since the first report of successful transplantation of a human malignant tumour to athymic nude mice (Rygaard and Povlsen, 1969).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bogden, A. E., Kelton, D. E., Cobb, W. R. and Esber, H. J. (1978). A rapid screening method for testing chemotherapeutic agents against human tumor xenografts. In Proceedings of the Symposium on the Use of Athymic (Nude) Mice in Cancer Research ( D. P. Houchens and A. A. Ovejera, eds), Gustav Fischer Verlag, Stuttgart, pp. 231–50

    Google Scholar 

  • Davy, M., Brustad, T. and Mossige, J. (1977). Irradiation of human ovarian tumors in nude mice. In Proceedings of the Second International Workshop on Nude Mice ( T. Nomura, N. Ohsawa, N. Tamaoki and K. Fujiwara, eds), University of Tokyo Press, Tokyo and Gustav Fischer Verlag, Stuttgart, pp. 491–8

    Google Scholar 

  • Epstein, A. L., Herman, M. M., Kim, H., Dorfman, R. F. and Kaplan, H. S. (1976). Biology of the human malignant lymphomas. III. Intracranial heterotransplantation in the nude, athymic mouse. Cancer, 37, 2158–76

    Article  CAS  PubMed  Google Scholar 

  • Fogh, J., Bean, M. A., Bruggen, J., Fogh, H., Fogh, J. M., Hammar, S. P., Kodera, Y., Loveless, J. D., Sorg, C. and Wright, W. C. (1978). Comparison of a human tumor cell line before and after growth in the nude mouse. In The Nude Mouse in Experimental and Clinical Research ( J. Fogh and B. C. Giovanella, eds), Academic Press, New York, pp. 215–34

    Google Scholar 

  • Freedman, V. H. and Shin, S. (1978). Use of nude mice for studies on the tumorigenicity of animal cells. In The Nude Mouse in Experimental and Clinical Research ( J. Fogh and B. C. Giovanella, eds), Academic Press, New York, pp. 353–84

    Google Scholar 

  • Giovanella, B. C. and Stehlin, J. S. (1974). Assessment of the malignant potential of cultured cells by injection in ‘nude’ mice. In Proceedings of the First International Workshop on Nude Mice (J. Rygaard and C. O. Povlsen, eds), Gustav Fischer Verlag, Stuttgart, pp 74, pp. 279–84

    Google Scholar 

  • Giovanella, B. C., Stehlin, J. S. and Shepard, R. C. (1977). Experimental chemotherapy of human breast carcinomas heterotransplanted in nude mice. In Proceedings of the Second International Workshop on Nude Mice (T. Nomura, N. Ohsawa, N. Tomaoki and K. Fujiwara, eds), University of Tokyo Press and Gustav Fischer Verlag, Stuttgart, pp. 475–81

    Google Scholar 

  • Giovanella, B. C., Stehlin, J. S. and Shepard, R. C. (1977). Experimental chemotherapy of human breast carcinomas heterotransplanted in nude mice. In Proceedings of the Second International Workshop on Nude Mice (T. Nomura, N. Ohsawa, N. Tomaoki and K. Fujiwara, eds), University of Tokyo Press and Gustav Fischer Verlag, Stuttgart, pp. 475–81

    Google Scholar 

  • Giovanella, B. C., Stehlin, J. S., Fogh, J. and Sharkey, F. E. (1978). Serial transplantation of human malignant tumors in nude mice and their use in experimental chemotherapy. In Proceedings of the Symposium on the Use of Athymic (Nude) Mice in Cancer Research (13. P. Houchens and A. A. Ovejera, eds), Gustav Fischer, Stuttgart, pp. 163–79

    Google Scholar 

  • Giovanella, B. C., Yim, S. O., Stehlin, J. S. and Williams, L. J., Jr (1972). Development of invasive tumours in the ‘nude’ mouse after injection of cultured human melanoma cells. J. natn. Cancer. Inst, 48, 1531–3

    CAS  Google Scholar 

  • Giovanella, B. C., Yim, S. O., Morgan, A. C., Stehlin, M. J. and Williams, L. J., Jr (1973). Metastases of human melanomas transplanted in ‘nude’ mice. J. natn. Cancer Inst, 50, 1051–3

    CAS  Google Scholar 

  • Hajdu, S. I. and Fogh, J. (1978). The nude mouse as a diagnostic tool in human tumor cell research. In The Nude Mouse in Experimental and Clinical Research ( J. Fogh and B. C. Giovanella, eds), Academic Press, New York, pp. 235–66

    Google Scholar 

  • Hata, J.-I., Ueyama, Y., Tamaoki, N., Furukawa, T. and Morita, K. (1978). Human neuroblastoma serially transplanted in nude mice and metastases. Cancer, 42, 468–73

    Article  CAS  PubMed  Google Scholar 

  • Hirohashi, S., Shimosato, Y., Kameya, T., Koide, T., Mukojima, T. and Taguchi, Y, (1977). Morphological and functional aspects of human liver cell carcinomas transplanted in nude mice. In Proceedings of the Second International Workshop on Nude Mice ( T. Nomura, N. Ohsawa, N. Tamaoki and K. Fujiwara, eds), University of Tokyo Press, Tokyo and Gustav Fischer Verlag, Stuttgart, pp. 427–34

    Google Scholar 

  • Houchens, D. P., Ovejera, A. A. and Barker, A. D. (1978). The therapy of human tumors in athymic (nude) mice. In Proceedings of the Symposium on the Use of Athymic (Nude) Mice in Cancer Research ( D. P. Houchens and A. A. Ovejera, eds), Gustav Fischer Verlag, Stuttgart, pp. 267–80

    Google Scholar 

  • Ikehara, S., Hamashima, Y. and Masuda, T. (1975). Immunological restoration of both thymectomisea and athymic nude mice by a thymus factor. Nature, Lond, 258, 335–7

    Article  CAS  Google Scholar 

  • Jacobsen. G. K., Povlsen, C. O. and Rygaard, J. (1979). Effects of thymus grafts in nude mice transplanted with human malignant tumours. Exptl. Cell Biol in press

    Google Scholar 

  • Kameya, T., Shimosato, Y., Hayashi, H. and Tsumuraya, M. (1977). Growth and differentiation of hormone-producing human tumors in nude mice. In Proceedings of the Second International Workshop on Nude Mice ( T. Nomura, N. Ohsawa, N. Tamaoki and K. Fujiwara, eds), University of Tokyo Press, Tokyo and Gustav Fischer Verlag, Stuttgart, pp. 405–16

    Google Scholar 

  • Lozzio, B. B., Machado, E. A., Lair, S. V. and Lozzio, C. B. (1977). Suppression of human myelosarcoma growth in athymic mice by a primate antiserum. Cancer Treatment Repts, 61, 1679–84

    CAS  Google Scholar 

  • Merenda, C., Sordat, B., Mach, J. P. and Carrel, S (1975). Human endometrial carcinomas serially transplanted in nude mice and established in continuous cell lines. Int. J. Cancer, 16, 559–70

    Article  CAS  PubMed  Google Scholar 

  • Nomura, T., Ohsawa, N., Tamaoki, N. and Fujiwara, K. (eds) (1977). Proceedings of the Second International Workshop on Nude Mice, University of Tokyo Press, Tokyo and Gustav Fischer Verlag, Stuttgart

    Google Scholar 

  • Osieka R. and Johnson, R. K. (1978). Evaluation of chemical agents in phase I clinical trial and earlier stages of development against xenografts of human colon carcinoma. In Proceedings of the Symposium on the Use of Athymic (Nude) Mice in Cancer Research ( D. P. Houchens and A. A. Ovejera, eds), Gustav Fischer, Stuttgart, pp. 217–23

    Google Scholar 

  • Osieka, R., Houchens, D. P., Goldin, A. and Johnson, R. K. (1977). Chemotherapy of human colon cancer xenografts in athymic nude mice. Cancer, 40, 2640–50

    Article  CAS  PubMed  Google Scholar 

  • Ozello, L., Sordat, B., Merenda, C., Carrel, S., Hurlimann, J. and Mach, J. P. (1974). Transplantation of a human mammary carcinoma cell line (BT 20) into nude mice. J. natn. Cancerinst, 52, 1669–72

    Google Scholar 

  • Pimm, M. V. and Baldwin, R. W. (1975). BCG immunotherapy of rat tumours in athymic nude mice. Nature, Lond, 254, 77–8

    Article  CAS  Google Scholar 

  • Povlsen, C. O. (1978). Growth of human tumors in nude mice and chemotherapy studies in this model. In Proceedings of the Symposium on the Use of Athymic (Nude) Mice in Cancer Research (D. P. Houchens and A. A. Ovejera, eds), Gustav Fischer Verlag, Stuttgart, pp. 187–94

    Google Scholar 

  • Povlsen, C. O. and Jacobsen, G. K. (1975). Chemotherapy of a human malignant melanoma transplanted in the nude mouse. Cancer Res, 35, 2790–6

    CAS  PubMed  Google Scholar 

  • Povlsen, C. O. and Rygaard, J. (1971). Heterotransplantation of human adenocarcinomas of the colon and rectum to the mouse mutant nude. A study of nine consecutive transplantations. Acta path. microbiol. scand. A, 79, 159–69

    CAS  Google Scholar 

  • Povlsen, C. O. and Rygaard, J. (1974). Effects of cyclophosphamide (EndoxanR) on a Burkitt’s lymphoma serially grown in nude mice. In Proceedings of the First International Workshop on Nude Mice (J. Rygaard and C. O. Povlsen, eds), Gustav Fischer Verlag, Stuttgart, pp. 285–92

    Google Scholar 

  • Povlsen, C. O. and Rygaard, J. (1975). Rejection patterns of three human malignant tumours transplanted in thymus grafted nude mice. Acta path. microbiol. scand. C, 83, 413–22

    Google Scholar 

  • Povlsen, C. O., Jacobsen, G. K. and Rygaard, J. (1973a). The mouse mutant nude as a model for testing of anticancer agents. In The Laboratory Animal in Drug Testing (A. Spiegel, ed), 5th ICLA Symposium, Gustav Fischer Verlag, Stuttgart, pp. 63–72

    Google Scholar 

  • Povlsen, C. O., Visfeldt, J., Rygaard, J. and Jensen, G. (1975). Growth patterns and chromosome constitutions of human malignant tumours after long-term serial transplantation in nude mice. Acta path. microbiol. scand. A, 83, 709–16

    CAS  Google Scholar 

  • Povlsen, C. O., Fialkow, P. J., Klein, E., Klein, G., Rygaard, J. and Weiner, F. (1973b). Growth and antigeneic properties of a biopsy-derived Burkitt’s lymphoma in thymus-less (nude) mice. Int. J. Cancer, 11, 30–9

    Article  CAS  PubMed  Google Scholar 

  • Rygaard, J. and Povlsen, C. O. (1969). Heterotransplantation of a human malignant tumour to ‘nude’ mice. Acta path. microbiol. scand, 77, 758–60

    Article  CAS  PubMed  Google Scholar 

  • Schmidt, M. and Good, R. A. (1975). Transplantation of human cancers to nude mice and effects of thymus grafts. J. natn. Cancer Inst, 55, 81–7

    CAS  Google Scholar 

  • Sharkey, F. E., Fogh, J. M., Hajdu, S. I., Fitzgerald, P. J. and Fogh, J. (1978). Experience in surgical pathology with human tumor growth in the nude mouse. In The Nude Mouse in Experimental and Clinical Research ( J. Fogh and B. C. Giovanella, eds), Academic Press, New York, pp. 187–214

    Google Scholar 

  • Shimosato, Y., Kameya, T., Kubota, T., Hirohashi, S., Hayashi, H, Ikeuchi, S. and Nagai, K. (1977). Experimental chemo-, radio-, and endocrine therapy for human cancers transplanted in nude mice. In Proceedings of the Second International Workshop on Nude Mice ( T. Nomura, O. Ohsawa, N. Tamaoki and K. Fujiwara, eds), University of Tokyo Press, Tokyo and Gustav Fischer Verlag, Stuttgart, pp. 499–508

    Google Scholar 

  • Sordat, B., Fritsché, R., Mach, J.-P., Carrel, S., Ozzello, L. and Cerottini, J.-C. (1974). Morphological and functional evaluation of human solid tumours serially transplanted in nude mice. In Proceedings of The First International Workshop on Nude Mice (C. O. Povlsen and J. Rygaard, eds), Gustav Fischer Verlag, Stuttgart, pp. 269–78

    Google Scholar 

  • Spang-Thomsen, M. and Visfeldt, J. (1977). Growth curves and radiation-induced synchronization of a human malignant melanoma transplanted to nude mice. In Proceedings of the Second International Workshop on Nude Mice ( T. Nomura, N. Ohsawa, N. Tamaoki and K. Fujiwara, eds), University of Tokyo Press, Tokyo and Gustav Fischer Verlag, Stuttgart, pp. 327–36

    Google Scholar 

  • Spang-Thomsen, M., Nielsen, A. and Visfeldt, J (1979a). Growth curves of three human malignant tumors in nude mice. J. natn. Cancer Inst in press

    Google Scholar 

  • Spang-Thomsen, M., Brunner, N., Schildt, T., Thorpe, S. M. and Nielsen, A. (1979b). Effect of oestrogen therapy on growth curve, receptor level, and histology of a human mammary carcinoma transplanted to nude mice. In Proceedings of the Symposium: Thymus Aplastic Nude Mice and Rats in Clinical Oncology Gustav Fischer Verlag, Stuttgart, in press

    Google Scholar 

  • Stiles, C. D. and Kawahara, A. A. (1978). The growth behavior of virus-transformed cells in nude mice. In The Nude Mouse in Experimental and Clinical Research ( J. Fogh and B. C. Giovanella, eds), Academic Press, New York, pp. 385–409

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pathological-Anatomical Institute, Kommunehospitalet, The University Institute of Pathological Anatomy, Copenhagen, Denmark

    C. O. Povlsen, M. Spang-Thomsen, J. Rygaard & J. Visfeldt

Authors
  1. C. O. Povlsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Spang-Thomsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Rygaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Visfeldt
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. MRC Laboratory Animals Centre, Carshalton,Surrey, England

    Stephen Sparrow

Copyright information

© 1980 The Medical Research Council

About this chapter

Cite this chapter

Povlsen, C.O., Spang-Thomsen, M., Rygaard, J., Visfeldt, J. (1980). Heterotransplantation of human malignant tumours to athymic nude mice. In: Sparrow, S. (eds) Immunodeficient Animals for Cancer Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05014-7_8

Download citation

Publish with us

Policies and ethics

Search

Navigation