Comparison of the growth of xenografts in various kinds of immunodeficient mice
One use of the immunodeficient mouse in cancer research is as a vehicle for the continuation of human tumours for further studies. Thymus-deprived (B) mice of diverse types (Castro, 1972; Detre and Gazet, 1973; Franks et al., 1976), immunosuppressed hamsters (Cobb,1974) and rats (Toolan, 1953) and congenitally athymic nude mice (nu nu) have supported human tumour grafts (Povlsen and Rygaard, 1971; Giovanella et al 1974; Detre et al.,1975) with varying degrees of success. The consensus of opinion seems to be that certain human malignancies, such as those from colon, rectum, bronchus or ovary, grow more easily subcutaneously in nude and B mice than do carcinomas of the breast and prostate or lymphomas or leukaemias. Certainly, our attempts to grow human breast carcinomas in certain immune-suppressed mice and hamsters, or immune-privileged sites, have usually proved unsuccessful (Detre et al., 1975).
KeywordsLymphoma Cage Adenocarcinoma Chlorine Trypsin
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