Comparison of the growth of xenografts in various kinds of immunodeficient mice

  • S. I. Detre


One use of the immunodeficient mouse in cancer research is as a vehicle for the continuation of human tumours for further studies. Thymus-deprived (B) mice of diverse types (Castro, 1972; Detre and Gazet, 1973; Franks et al., 1976), immunosuppressed hamsters (Cobb,1974) and rats (Toolan, 1953) and congenitally athymic nude mice (nu nu) have supported human tumour grafts (Povlsen and Rygaard, 1971; Giovanella et al 1974; Detre et al.,1975) with varying degrees of success. The consensus of opinion seems to be that certain human malignancies, such as those from colon, rectum, bronchus or ovary, grow more easily subcutaneously in nude and B mice than do carcinomas of the breast and prostate or lymphomas or leukaemias. Certainly, our attempts to grow human breast carcinomas in certain immune-suppressed mice and hamsters, or immune-privileged sites, have usually proved unsuccessful (Detre et al., 1975).


Nude Mouse Foetal Liver Immunodeficient Mouse Athymic Nude Mouse Cytosine Arabinoside 
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  1. Baldamus, C. A., McKenzie, I. F. C., Winn, H. J. and Russell, P. S. (1973). Acute destruction by humoral antibody of rat skin grafted to mice. J. Immunol, 110, 1532–41PubMedGoogle Scholar
  2. Billingham, R. E. and Medawar, P. B. (1951). Technique of free grafting in mammals. J. exp. Biol, 28, 385–402Google Scholar
  3. Bradley, N. J., Bloom, H. J. G., Davies, A. J. S. and Swift, S. M. (1978). Growth of human gliomas in immune deficient mice: a possible model for pre-clinical therapy studies. Br. J. Cancer, 38, 263–72PubMedCentralCrossRefPubMedGoogle Scholar
  4. Castro, J. E. (1972). Human tumours grown in mice. Nature new Biol, 239, 83–4CrossRefPubMedGoogle Scholar
  5. Cobb, L. M. (1974). The hamster as a host for the growth and study of human tumour cell populations. Cancer Res, 34, 958–61PubMedGoogle Scholar
  6. Davies, A. J. S., Leuchars, E., Wallis, V. and Koller, P. C. (1966). The mitotic response of thymus derived cells to antigenic stimulus. Transplantation, 4, 438–51CrossRefPubMedGoogle Scholar
  7. Davies, A. J. S. (1969). The thymus and the cellular basis of immunity. Transplantation Rev, 1, 43–91Google Scholar
  8. Detre, S. I. and Gazet, J-C. (1973). Transplantation of human tumour to immune deprived mice treated with antithymocyte serum. Br. J. Cancer, 28, 412–6PubMedCentralCrossRefPubMedGoogle Scholar
  9. Detre, S. I., Davies, A. J. S. and Connors, T. A. (1975). New models for cancer chemotherapy. Cancer Chemother. Repts, Part 2, 5, 133–43Google Scholar
  10. Detre, S. I. (1978). The grafting of human tumours to immunodeficient mice. MPhil thesis, University of London.Google Scholar
  11. Doenhoff, M. J., Davies, A. J. S., Leuchars, E. and Wallis, V. (1970). The thymus and circulating lymphocytes of mice. Proc. R. Soc. B, 176, 69–85CrossRefGoogle Scholar
  12. Franks, C. R., Bishop, D. and Reeson, D. (1976). The growth of tumour xenografts in thymectomised high dose irradiated mice reconstituted with syngeneic bone marrow cells incubated with anti-thymocyte serum. Br. J. Cancer, 33, 112–5PubMedCentralCrossRefPubMedGoogle Scholar
  13. Giovanella, B. C., Stehlin, J. S. and Williams, L. J. (1974). Heterotransplantation of human malignant tumours in `nude’ thymusless mice. II. Malignant tumours induced by injection of cell cultures deprived from human solid tumours. J. natn. Cancer Inst.. 52, 921–7Google Scholar
  14. McPherson, C. W. (1963). Reduction of Pseudomonas aeroginosa and coliform bacteria in mouse drinking water following treatment with hydrochloric acid or chlorine. Lab. Animal Care, 13, 737–44Google Scholar
  15. Miller, J. F. A. P., Doak, S. M. and Cross, A. M. (1963). Role of the thymus in recovery of the immune mechanism in the irradiated adult mouse. Proc. Soc. exp. Biol. Med, 112, 785–92CrossRefGoogle Scholar
  16. Mitchley, B. C. V., Clarke, S. A., Connors, T. A. and Neville, A. M. (1975). Hexamethylmelamine-induced regression of human lung tumours growing in immunedeprived mice. Cancer Res, 35, 1099–102PubMedGoogle Scholar
  17. Povisen, C. O. and Rygaard, J. (1971). Heterotransplantation of human adenocarcinomas of the colon and rectum to the mouse mutant nude. A study of 9 consecutive transplantations. Acta path. microbiol. scand. A, 79, 159–69Google Scholar
  18. Steel, G. G., Courtenay, V. D. and Rostum, A. Y. (1978). Improved immune-suppression techniques for the xenografting of human tumours. Br. J. Cancer, 37, 224–30PubMedCentralCrossRefPubMedGoogle Scholar
  19. Toolan, H. W. (1953). Growth of human tumours in cortisone-treated laboratory animals. The possibility of obtaining permanently transplantable human tumours. Cancer Res, 13, 389–94PubMedGoogle Scholar

Copyright information

© The Medical Research Council 1980

Authors and Affiliations

  • S. I. Detre
    • 1
  1. 1.Institute of Cancer Research: Royal Cancer HospitalChester Beatty Research InstituteLondonUK

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