Abstract
The lymph nodes of normal mammals contain several types of non-lymphatic cells (for review see Lennert and Müller-Hermelink, 1975). In both the cortex and the medulla, endothelial cells of blood vessels and of lymph sinuses as well as fibroblastic reticular cells and macrophages are present in varying numbers. In addition to these non-specific elements, the B and T cell-dependent areas of the lymph node are populated by specific non-lymphatic cells. Thus, the primary and secondary follicles of the lymph nodes (and of other peripheral lymphatic organs) contain dendritic reticular cells (DRC), which are characterised by branching cytoplasmic processes (for review see Nossal and Ada, 1971). These cells form a delicate, three-dimensional network which supports the lymphocyte population composed predominantly of B cells. As has been shown by several autoradiographic and immunohistochemical studies, DRCs are able to fix antigen-antibody complexes at the surface of their cytoplasmic processes (Nossal and Ada, 1971). It is assumed that these cells play a substantial role in the proliferation and differentiation of B lymphocytes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Auerbach, R. (1976). Ontogeny of immune responsiveness in the mouse. Ann. Immunol. (Inst. Pasteur), 127C, 983–92
Claesson, M. H. and Jörgensen, O. (1974). Comparative studies of the paracortical post-capillary venules of normal and nude mice. Acta path. microbiol. scand. B, 82, 249–57
De Sousa, M. and Pritchard, H. (1974). The cellular basis of immunological recovery in nude mice after thymus grafting. Immunology, 26, 769–76
De Sousa, M. A. B., Parrott, D. M. V. and Pantelouris, E. M. (1969). The lymphoid tissues in mice with congenital aplasia of the thymus. Clin. exp. immunol, 4, 637–44
Friess, A. (1976). Interdigitating reticulum cells in the popliteal lymph node of the rat. Cell Tissue Res, 170, 43–60
Gillette, R. W. (1975). Homing of labelled lymphoid cells in athymic mice: evidence for additional immunologic defects. Cellul. Immunol, 17, 374–82
Groscurth, P. and Kistler, G. (1975a). Histogenesis of the immune system of the ‘nude’ mouse. I. Prenatal development of the thymus: a light microscopical study. Beitr. Path, 154, 109–24
Groscurth, P. and Kistler, G. (1975b). Histogenesis of the immune system of the ‘nude’ mouse. IV. The ultrastructure of the thymus anlage in 12- and 13-day-old embryos. Beitr. Path, 156, 359–75
Groscurth, P., Whitener, M. and Töndury, G. (1975). Histogenesis of the immune system of the ‘nude’ mouse. II. Postnatal development of the thymus: a light microscopical study. Beitr. Path, 154, 125–39
Hoffmann-Fezer, G., Rodt, H. and Thierfelder, S. (1977). Immunohistochemical identifica- tion of T and B lymphocytes delineated by the unlabelled antibody enzyme method. II. Anatomical distribution of T and B cells in lymphoid organs of nude mice. Beitr. Path, 161, 17–26
Hougen, H. P. and Röpke, C. (1975). Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution. Clin. exp. Immunol, 22, 528–38
Jacobson, E. B., Caporale, L. H. and Thorbecke, G. J. (1974). Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice. Cellul. Immunol, 13, 416–430
Kaiserling, E. and Lennert, K. (1974). Die interdigitierende Reticulumzelle im menschlichen Lymphknoten. Virchows’ Arch. B, Zellpath, 16, 51–61
Kaiserling, E., Stein, H. and Milder-Hermelink, H. K. (1974). Interdigitating reticulum cells in the human thymus. Cell Tissue Res, 155, 47–55
Kindred, B. (1978). The nude mouse in studying T cell differentiation. In The Nude Mouse in Experimental and Clinical Research, ( J. Fogh and B. C. Giovanella, eds), Academic Press, New York, pp. 111–34
Lennert, K. and Muller-Hermelink, H. K. (1975). Lymphocyten und ihre Funktionsformen-Morphologie, Organisation und immunologische Bedeutung. Verhandl. anat. Ges, 69, 19–62
Mitchell, J., Pye, J., Holmes, M. C. and Nossal, G. J. V. (1972). Antigens in immunity. Antigen localization in congenitally athymic ‘nude’ mice. Austral. J. exp. Biol. med. Sci, 50, 637–50
Muntener, M., Groscurth, P. and Kistler, G. (1975). Histogenesis of the immune system of the ‘nude’ mouse. III. Postnatal development of lymph nodes and spleen: a light microscopical study. Beitr. Path, 155, 56–71
Nossal, G. J. V. and Ada, G. L. (1971). Antigens, Lymphoid Cells and the Immune Response, Academic Press, New York
Pantelouris, E. M. (1968). Absence of the thymus in a mouse mutant. Nature, Lond, 217, 370–1
Raff, M. C. and Wortis, H. H. (1970). Thymus dependence of 0-bearing cells in the peripheral lymphoid tissues of mice. Immunology, 18, 931–42
Rygaard, J. and Povlsen, C. O. (1974). Effects of homozygosity of the nude (nu) gene in three inbred strains of mice. Acta path. microbiol. scand. A, 82, 48–70
Veerman, A. J. P. (1974). On the interdigitating cells in the thymus-dependent area of the rat spleen: a relation between the mononuclear phagocyte system and T lymphocytes. Cell Tissue Res, 148, 247–57
Veerman, A. J. P. and van Ewijk, W. (1975). White pulp compartments in the spleen of rats and mice. Cell Tissue Res, 156, 417–41
Veldman, J. E. (1970). Histophysiology and electron microscopy of the immune response. PhD thesis, Drukkerij Dijkstra-Niemeyer, Groningen, The Netherlands
Weissman, I. L., Gutman, G. A., Friedberg, S. H. and Jerabek, L. (1976). Lymphoid tissue architecture. III. Germinal centers, T-cells, and thymus-dependent vs thymus-independent antigens. Adv exp. Med. Biol, 66, 229–37
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1980 The Medical Research Council
About this chapter
Cite this chapter
Groscurth, P. (1980). Morphology of non-lymphatic cells in the lymph node of the nude mouse. In: Sparrow, S. (eds) Immunodeficient Animals for Cancer Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-05014-7_5
Download citation
DOI: https://doi.org/10.1007/978-1-349-05014-7_5
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-05016-1
Online ISBN: 978-1-349-05014-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)