Cytofluorometric analysis of tumours in nude mice

  • P. Sordillo
  • H. Hansen
  • L. Helson
  • C. Helson

Abstract

Since the original demonstration by Rygaard and Povlsen (1969) that human tumours could be grown in nude mice, the use of the nude mouse bearing human tumour models to test for anticancer activity of various drugs, surgery and radiation has been attempted in some laboratories (Povlsen, 1978; Helson et al., 1978). Although early studies have been very promising, there are certain difficulties associated with this model. Age (Sordat et al., 1977), natural killer cell activity (Holden et al., 1978), site of tumour (Auerbach et al., 1978), and inoculum size (Helson et al., 1977) in the animal host may influence heterotransplanted tumour growth. Information concerning the growth patterns of untreated heterotransplanted tumours is thus required for a better understanding of how we can use this model.

Keywords

Lymphoma Sarcoma Iodide Glutamine Nylon 

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Copyright information

© The Medical Research Council 1980

Authors and Affiliations

  • P. Sordillo
    • 1
  • H. Hansen
    • 1
  • L. Helson
    • 1
  • C. Helson
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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