Abstract
The clinical importance of the ability of some drugs to act as haptens and to participate in immunological reactions relates to the development of allergic drug-induced rèactions either during therapy or in circumstances of occupational exposure to the drug. The majority of adverse reactions to drugs are not immunologically mediated but can be understood on the basis of direct toxicity owing to overdosage, to side effects and to secondary effects dependent on the primary beneficial action of the drug and in some instances to an unexplained pattern of drug handling on the part of the patient. It is these idiosyncratic adverse reactions that cause the main problems in differential diagnosis of allergic drug reactions. However, only the unambiguous demonstration of the immunochemical properties of the drug, or of a drug-derived product allows a firm diagnosis of drug allergy.
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© 1979 Institute of Biology Endowment Trust Fund
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Dewdney, J.M. (1979). Drugs as haptens. In: Turk, J.L., Parker, D. (eds) Drugs and Immune Responsiveness. Biological Council Co-ordinating Committee for Symposia on Drug Action. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04636-2_9
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DOI: https://doi.org/10.1007/978-1-349-04636-2_9
Publisher Name: Palgrave Macmillan, London
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