Skip to main content
SpringerLink
Log in
Book cover

Drugs and Immune Responsiveness pp 119–131Cite as

Palgrave Macmillan

Effect of levamisole in vivo and in vitro on lymphocytes from patients with Behcet’s syndrome and recurrent oral ulceration

  • Chapter

  • 100 Accesses

Abstract

Levamisole (1-2, 3, 5, 6-tetrahydro-6-phenylimidazo [2, 1-b] -thiazol mono-hydrochloride) is an antihelminthic drug that can modulate immune responses in man both in vivo and in vitro (Tripodi et al., 1973; Pabst and Crawford, 1975; Huskisson et al., 1976; Ivanyi and Lehner, 1977) and in animals (Renoux and Renoux, 1973; Fischer et al., 1975). Enhancement of lymphocyte proliferation in vitro by mitogens or the mixed leucocyte culture reaction has been reported when levamisole was added to lymphocyte cultures (Hadden et al., 1975; Sampson and Lui, 1976).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Al-Ibrahim, M. S., Holzman, R. S. and Lawrence, H. S. (1977). J. infect. Dis., 135, 517

    Article  Google Scholar 

  • Boyum, A. (1968). Scand. J. clin. Lab. Invest., 21, (Suppl. 97 ), 77

    Article  Google Scholar 

  • Chan, S. H. and Simons, M. J. (1975). Lancet, i, 1246

    Article  Google Scholar 

  • Chirigos, A., Pearson, J. W. and Pryor, J. (1973). Cancer Res., 33, 2615

    Google Scholar 

  • De Meyer, J., Degraeve, M., Clarysse, J., De Loose, F. and Peremans, W. (1977). Brit. Med. J., 1, 671

    Article  Google Scholar 

  • Dolby, A. E. (1969). Immunology, 17, 709

    Google Scholar 

  • Donatsky, O. (1976). Acta Path. Micro. Scand., Sec. C, 84, 227

    Google Scholar 

  • Fischer, G. W., Podgore, J. K., Bass, J. W., Kelley, J. L. and Kobayashi, G. Y. (1975). J. infect. Dis., 132, 578

    Article  Google Scholar 

  • Fischer, G. W., Crumrine, M. H., Balk, M. W., Chang, S. P., Hokama, Y., Heu, P. and Chou, S. C. (1976). Proc. 3rd Con. Modulation of Host Resistance in the Prevention of Treatment of Induced Neoplasias, Bethesda, MD

    Google Scholar 

  • Hadden, J. W., Coffey, R. G., Hadden, E. M., Lopez-Corrales, E. and Sunshine, G.H. (1975). Cell. Immunol. 20, 98

    Article  Google Scholar 

  • Hoebeke, J. and Franchi, G. (1973). J. reticuloendothel. Soc., 14, 317

    Google Scholar 

  • Huskisson, E. C., Scott, J., Balme, H. W., Dieppe, P. A., Trapnell, J. and Willoughby, D. A. (1976). Lancet, i, 393

    Google Scholar 

  • Ivanyi, L. and Lehner, T. (1977). Scand. J. Immunol., 6, 219

    Article  Google Scholar 

  • Keller, R. (1974). Immunology, 27, 285

    Google Scholar 

  • Kint, A. and Verlinden, L. (1974). New Eng. J. Med., 291, 308

    Google Scholar 

  • Lehner, T. (1967). Immunology, 13, 159.

    Google Scholar 

  • Lehner, T., Wilton, J. M. A., Challacombe, S. J. and Ivanyi, L. (1974). Clin. exp. Immunol., 16, 481

    Google Scholar 

  • Lehner T., Wilton, J. M. A. and Ivanyi, L. (1976). Lancet, ii,926

    Article  Google Scholar 

  • Lima, A. O., Javierre, M. Q., Dias da Silva, W. and Camara, D. S. (1974). Experientia (Basel), 30, 945

    Article  Google Scholar 

  • Merluzzi, V. J., Badger, A. M., Kaiser, C. W. and Cooperband, S. R. (1975). Clin. exp. Immunol., 22, 486

    Google Scholar 

  • Olson, J. A., Nelms, D. C., Silverman, S. and Spitler, L. E. (1976). Oral Surg. Med. Path., 41, 588

    Article  Google Scholar 

  • Pabst, H. F. and Crawford, J. (1975). Clin. exp. Immunol., 21, 468

    Google Scholar 

  • Pike, M. C. and Snyderman, R. (1976). Nature, 261, 136

    Article  Google Scholar 

  • Renoux, G. and Renoux, M. (1973). Infect. Immun., 8, 544

    Google Scholar 

  • Renoux, G. and Renoux, M. (1977). J. exp. Med., 145, 466

    Article  Google Scholar 

  • Renoux, G., Kassel, R. L, Renoux, M., Fiore, N. G., Guillaumin, J. M. and Palat, A. (1974). Proc. 3rd. Con. Modulation of Host Immune Resistance in the Prevention of Treatment of Induced Neoplasias, Bethesda, MD

    Google Scholar 

  • Renoux, G., Renoux, M., Teller, M. N., McMahon, N. and Guillaumin, J. M. (1976). Clin. exp. Immunol., 25, 288

    Google Scholar 

  • Rogers, R. S., Sams, W. M. and Shorter, R. G. (1974). Archs. Derm., 109, 361

    Article  Google Scholar 

  • Sampson, D. and Lui, A. (1976). Cancer Res., 36, 952

    Google Scholar 

  • Schultz, R. M., Papamathiallis, J. D., Luetzler, J. and Chirigos, M. A. (1977). Cancer Res., 37, 3338

    Google Scholar 

  • Symoens, J. and Rosenthal, M. (1977). J. reticuloendothel. Soc., 21, 175

    Google Scholar 

  • Tripodi, D., Parks, L. C. and Brugmans, J. (1973). New Eng. J. Med., 289, 354

    Article  Google Scholar 

  • Verhaegen, H., De Cree, J. and Brugmans, J. (1973). Lancet, ii, 842

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Oral Immunology and Microbiology, Guy’s Hospital Medical and Dental Schools, London, SE1 9RT, UK

    T. Lehner & J. M. A. Wilton

Authors
  1. T. Lehner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. M. A. Wilton
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Basic Medical Sciences, Royal College of Surgeons of England and University of London, UK

    J. L. Turk  & Darien Parker  & 

Copyright information

© 1979 Institute of Biology Endowment Trust Fund

About this chapter

Cite this chapter

Lehner, T., Wilton, J.M.A. (1979). Effect of levamisole in vivo and in vitro on lymphocytes from patients with Behcet’s syndrome and recurrent oral ulceration. In: Turk, J.L., Parker, D. (eds) Drugs and Immune Responsiveness. Biological Council Co-ordinating Committee for Symposia on Drug Action. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04636-2_7

Download citation

Publish with us

Policies and ethics

Search

Navigation