Abstract
D-Penicillamine is now a well-established antirheumatic drug (Multicentre Trial Group, 1973) and has been shown to inhibit the progression of rheumatoid arthritis (Gibson et al., 1976), yet its mode of action is unclear; especially as it fails to affect the traditional models of acute inflammation. Studies with the experimental antigen-induced arthritis model of Dumonde and Glynn (1962) in rabbits have shown that D-penicillamine can reduce the-severity of the inflammation (Puschel et al., 1976; Hunneyball et al., 1977). In contrast, in the rat adjuvant arthritis model, D-penicillamine not only fails to control the swelling of the primary lesion (Liyanage and Currey, 1972), but also causes enhancement of the secondary lesions (Arrigoni-Martelli and Bramm, 1975).
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© 1979 Institute of Biology Endowment Trust Fund
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Hunneyball, I.M., Stanworth, D.R. (1979). The effect of D-penicillamine on humoral and cellular immune responses in animals. In: Turk, J.L., Parker, D. (eds) Drugs and Immune Responsiveness. Biological Council Co-ordinating Committee for Symposia on Drug Action. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04636-2_4
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DOI: https://doi.org/10.1007/978-1-349-04636-2_4
Publisher Name: Palgrave Macmillan, London
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