Abnormal function of the endocrine pancreas in genetic and experimentally induced obesity in rodents

  • Anne Beloff-Chain


Hyperinsulinaemia is a consistent feature of obesity; studies on the hyperactivity of the β-cell function of the endocrine pancreas in experimental and genetic obesity in rodents are described. Evidence that the hypersecretion of insulin may be one of the primary defects in many forms of obesity is discussed. Adrenal cortical hyperplasia and increased circulating glucocorticosteroids, as well as high pituitary ACTH levels, are among the multiple endocrine abnormalities described in the ob/ob mice.


Insulin Secretion Pituitary Gland Obese Mouse Glucagon Secretion Endocrine Pancreas 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abraham, R. R., Dade, E., Elliott, J. and Hems, D. A. (1971). Hormonal control of intermediary metabolism in obese hyperglycemic mice. II. Levels of plasma free fatty acids, immunoactive insulin and liver glycogen. Diabetes, 20, 535–541CrossRefGoogle Scholar
  2. Atkins, T. and Matty, A. J. (1971). Adenyl cyclase and phosphodiesterase activity in the isolated islets of Langerhans of obese mice and their lean littermates; the effect of glucose, adrenaline and drugs on adenyl cyclase activity. J. Endocrinol., 51, 67–78CrossRefGoogle Scholar
  3. Beevor, S., Beloff-Chain, A., Donaldson, A. and Edwardson, J. A. (1977). Pituitary intermediate lobe function in genetically obese (ob/ob) and lean mice. Proc. Physiol. Soc., November, 73 PGoogle Scholar
  4. Beloff-Chain, A., Bogdanovic, S. and Cawthorne, M. A. (1979). J. Endocrinol. (in press)Google Scholar
  5. Beloff-Chain, A., Edwardson, J. A. and Hawthorn, J. (1975). The influence of the pituitary gland on insulin secretion in genetically obese (ob/ob) mice. J. Endocrinol., 65, 109–116CrossRefGoogle Scholar
  6. Beloff-Chain, A., Edwardson, J. A. and Hawthorn, J. (1976). Corticotrophin-like intermediate lobe peptide as an insulin secretagogue. J. Endocrinol., 73, 28P - 29 PGoogle Scholar
  7. Beloff-Chain, A. and Hawthorn, J. (1976). The release of insulin from pancreatic islets of lean and obese mice stimulated in vitro by pituitary glands from obese mice and by high glucose concentrations. FEBS Letters, 64, 214–217CrossRefGoogle Scholar
  8. Beloff-Chain, A., Hawthorn, J. and Green, D. (1975). Influence of the pituitary gland from the homozygote (+/+) and heterozygote (obl+) lean mouse on insulin secretion in vitro. FEES Letters, 55, 72–74CrossRefGoogle Scholar
  9. Beloff-Chain, A., Newman, M. E. and Mansford, K. R. L. (1973). In vitro studies on insulin secretion in the genetically obese mouse. Diabetologia, 9, 447–452Google Scholar
  10. Beloff-Chain, A., Newman, M. E. and Mansford, K. R. L. (1977). Factors influencing insulin and glucagon. secretion in lean and genetically obese mice. Horm. Metab. Res., 9, 33–36CrossRefGoogle Scholar
  11. Bleisch, V. B., Mayer, J. and Dickie, M. M. (1952). Familial diabetes mellitus and insulin resistance associated with hyperplasia of the islets of Langerhans in mice. Am. J. Pathol., 28, 369–385Google Scholar
  12. Boozer, C. N. and Mayer, J. (1976). Effect of long term restricted insulin production in obese hyperglycemic (genotype ob/ob) mice. Diabetologia, 12, 181–187CrossRefGoogle Scholar
  13. Chieri, R. A., Basabe, J. C. and Farina, J. M. S. (1976). Evidence for a hypophyseal factor that stimulates insulin secretion by the pancreas (Insulinotrophine). Horm. Metab. Res., 8, 329–332CrossRefGoogle Scholar
  14. Dubuc, D. U., Mobley, D. W., Mahler, R. J. and Ensinek, J. M. (1977). Immunoreactive glucagon levels in obese hyperglycaemic (ob/ob) mice. Diabetes, 26, 841–846CrossRefGoogle Scholar
  15. Eaton, P. R., Conway, M. and Schade, D. S. (1976). Endocrine glucagon regulation in genetically hyperlipemic obese rats. Am. J. Physiol, 230, 1336–1341Google Scholar
  16. Edwardson, J. A. and Hough, C. A. M. (1975). The pituitary adrenal system of the genetically obese (ob/ob) mouse. J. Endocrinol, 65, 99–107CrossRefGoogle Scholar
  17. Findlay, J. A., Rookledge, K. A., Beloff-Chain, A. and Lever, J. D. (1973). A combined biochemical and histological study on the islets of Langerhans in the genetically obese hyperglycemic mouse and in the lean mouse, including observations on the effects of streptozotocin treatment. J. Endocrinol., 56, 571–583CrossRefGoogle Scholar
  18. Frohman, L. A. and Bernardis, L. L. (1968). Growth hormone and insulin levels in weanling rats with ventromedial hypothalamic lesions. Endocrinology, 82, 1125–1132CrossRefGoogle Scholar
  19. Genuth, S. M. (1969). Hyperinsulinism in mice with genetically determined obesity. Endo-crinology, 84, 386–391CrossRefGoogle Scholar
  20. Gonet, A. E., Stauffacher, W., Pictet, R. and Renold, A. E. (1965). Obesity and diabetes mellitus with striking hyperplasia of the islets of Langerhans in Spiny Mice (Acomys cahirinus). 1. Histological findings and preliminary metabolic observations. Diabetologia, 1, 162–171Google Scholar
  21. Hellerstrom, C., Hellman, B. and Larsson, S. (1962). Some aspects of the structure and histochemistry of the adrenals in obese hyperglycemic mice. Acta Pathol. Microbiol Scand., 54, 365–372CrossRefGoogle Scholar
  22. Inoue, S., Bray, G. A. and Muller, Y. S. (1977). Effect of transplantation of pancreas on development of hypothalamic obesity. Nature, 266, 732–744CrossRefGoogle Scholar
  23. Lavine, R. L., Voyles, N., Perrino, P. and Recant, L. (1975). The effect of fasting on tissue cyclic c AMP and plasma glucagon in the obese hyperglycemic mouse. Endocrinology, 97, 615–620CrossRefGoogle Scholar
  24. Martin, J. M., Konijnendijk, W. and Bouman, P. R. (1974). Insulin and growth hormone secre- tion in rats with ventromedial hypothalamic lesions maintained on restricted food intake. Diabetes, 23, 203–208CrossRefGoogle Scholar
  25. Naeser, P. (1974). Function of the adrenal cortex in obese hyperglycemic mice (gene symbol ob). Diabetologia, 10, 449–453CrossRefGoogle Scholar
  26. Newman, M. E. (1977). Glycogen metabolism and cyclic AMP levels in isolated islets of lean and genetically obese mice. Horm. Metab. Res., 9, 358–361CrossRefGoogle Scholar
  27. Rohner, R., Dufour, A., Karakash, C., Le Marchand, Y., Ruf, B. and Jeanrenaud, B. (1977). Immediate effect of lesion of the ventromedial hypothalamic area upon glucose induced insulin secretion in anaesthetized rats. Diabetes, 13, 239–242Google Scholar
  28. Scott, A. P., Ratcliffe, J. G., Reese, L. H., Landon, J., Bennett, H. P. J., Lowry, P. J. and McMartin, C. (1973). Pituitary peptides. Nature New Biol., 244, 65–67CrossRefGoogle Scholar
  29. Shino, A., Matsuo, T., Iwatsuka, H. and Suzuoki, Z. (1973). Structural changes of pancreatic islets in genetically obese rats. Diabetologia, 9, 413–421CrossRefGoogle Scholar
  30. Stern, J., Johnson, P. R., Greenwood, M. R. C., Zucker, L. M. and Hirsch, J. (1972). Insulin resistance and pancreatic insulin release in the genetically obese Zucker rat. Proc. Soc. Exp. Biol., 139, 66–69CrossRefGoogle Scholar
  31. Wrenshall, C. A., Andrus, S. B. and Mayer, J. (1955). High levels of pancreatic insulin coexistent with hyperplasia and degranulation of beta-cells in mice with hereditary obese hyperglycemic syndrome. Endocrinology, 56, 335–340CrossRefGoogle Scholar
  32. York, D. A. and Bray, G. A. (1972). Dependence of hypothalamic obesity on insulin, the pituitary and the adrenal gland. Endocrinology, 90, 885–894CrossRefGoogle Scholar
  33. Zucker, L. M. and Antoniades, H. N. (1972). Insulin and obesity in the Zucker genetically obese rat ‘fatty’. Endocrinology, 90, 1320–1330CrossRefGoogle Scholar

Copyright information

© The Medical Research Council 1979

Authors and Affiliations

  • Anne Beloff-Chain
    • 1
  1. 1.Department of BiochemistryImperial College of Science and TechnologyLondonUK

Personalised recommendations