Abnormal function of the endocrine pancreas in genetic and experimentally induced obesity in rodents
Hyperinsulinaemia is a consistent feature of obesity; studies on the hyperactivity of the β-cell function of the endocrine pancreas in experimental and genetic obesity in rodents are described. Evidence that the hypersecretion of insulin may be one of the primary defects in many forms of obesity is discussed. Adrenal cortical hyperplasia and increased circulating glucocorticosteroids, as well as high pituitary ACTH levels, are among the multiple endocrine abnormalities described in the ob/ob mice.
KeywordsInsulin Secretion Pituitary Gland Obese Mouse Glucagon Secretion Endocrine Pancreas
Unable to display preview. Download preview PDF.
- Beevor, S., Beloff-Chain, A., Donaldson, A. and Edwardson, J. A. (1977). Pituitary intermediate lobe function in genetically obese (ob/ob) and lean mice. Proc. Physiol. Soc., November, 73 PGoogle Scholar
- Beloff-Chain, A., Bogdanovic, S. and Cawthorne, M. A. (1979). J. Endocrinol. (in press)Google Scholar
- Beloff-Chain, A., Edwardson, J. A. and Hawthorn, J. (1976). Corticotrophin-like intermediate lobe peptide as an insulin secretagogue. J. Endocrinol., 73, 28P - 29 PGoogle Scholar
- Beloff-Chain, A., Newman, M. E. and Mansford, K. R. L. (1973). In vitro studies on insulin secretion in the genetically obese mouse. Diabetologia, 9, 447–452Google Scholar
- Bleisch, V. B., Mayer, J. and Dickie, M. M. (1952). Familial diabetes mellitus and insulin resistance associated with hyperplasia of the islets of Langerhans in mice. Am. J. Pathol., 28, 369–385Google Scholar
- Eaton, P. R., Conway, M. and Schade, D. S. (1976). Endocrine glucagon regulation in genetically hyperlipemic obese rats. Am. J. Physiol, 230, 1336–1341Google Scholar
- Findlay, J. A., Rookledge, K. A., Beloff-Chain, A. and Lever, J. D. (1973). A combined biochemical and histological study on the islets of Langerhans in the genetically obese hyperglycemic mouse and in the lean mouse, including observations on the effects of streptozotocin treatment. J. Endocrinol., 56, 571–583CrossRefGoogle Scholar
- Gonet, A. E., Stauffacher, W., Pictet, R. and Renold, A. E. (1965). Obesity and diabetes mellitus with striking hyperplasia of the islets of Langerhans in Spiny Mice (Acomys cahirinus). 1. Histological findings and preliminary metabolic observations. Diabetologia, 1, 162–171Google Scholar
- Rohner, R., Dufour, A., Karakash, C., Le Marchand, Y., Ruf, B. and Jeanrenaud, B. (1977). Immediate effect of lesion of the ventromedial hypothalamic area upon glucose induced insulin secretion in anaesthetized rats. Diabetes, 13, 239–242Google Scholar