Presence of a non-peptide morphine-like compound in human CSF and urine
In our laboratory, we have been developing the formation of antibodies to drugs for a number of reasons but one that has been foremost in our thinking is whether these very specific proteins that have been generated for particular drug molecules can act as surrogate receptors. The antibody possesses many of the qualities of the receptor, and so it should be reasonable to assume that if there are endogenous substances in the body which impinge upon the opiate receptor, and if the receptor recognizes morphine, the antibody developed to bind morphine should also bind an endogenous opiate.
KeywordsMorphine Trypsin Decadron Alkaloid Prednisone
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- Pasternak, G. W., Goodman, R. and Snyder, S. H. (1975). Life Sei., 16, 1765-9 Terenius, L. and Wahlström, A. (1975). Life Sci., 16, 1759 - 64Google Scholar