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Presence of a non-peptide morphine-like compound in human CSF and urine

  • S. Spector
  • J. Shorr
  • J. Finberg
  • K. Foley

Abstract

In our laboratory, we have been developing the formation of antibodies to drugs for a number of reasons but one that has been foremost in our thinking is whether these very specific proteins that have been generated for particular drug molecules can act as surrogate receptors. The antibody possesses many of the qualities of the receptor, and so it should be reasonable to assume that if there are endogenous substances in the body which impinge upon the opiate receptor, and if the receptor recognizes morphine, the antibody developed to bind morphine should also bind an endogenous opiate.

Keywords

None None Opiate Receptor Hybrid Cell Line Receptor Binding Assay Endogenous Opiate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Berson, S. A. and Yalow, R. S. (1959). Nature, 184, 1648 - 9PubMedGoogle Scholar
  2. Spector, S. and Parker, C. W. (1970). Science, 168, 1347 - 8PubMedCrossRefGoogle Scholar
  3. Gintzler, A. R., Mohaci, E. and Spector, S. (1976). Eur. J. Pharmac., 38, 149 - 56CrossRefGoogle Scholar
  4. Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A. and Morris, H. R. (1975). Nature, 258, 577 - 9PubMedCrossRefGoogle Scholar
  5. Pasternak, G. W., Goodman, R. and Snyder, S. H. (1975). Life Sei., 16, 1765-9 Terenius, L. and Wahlström, A. (1975). Life Sci., 16, 1759 - 64Google Scholar
  6. Li, C. H. and Chung, D. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 1145 - 8CrossRefGoogle Scholar
  7. Blume, A. J., Shorr, J., Finberg, J. P. M. and Spector, S. (1977). Proc. natn. AcacL Sci. U.S.A., 74, 4927 - 31CrossRefGoogle Scholar
  8. Klee, W. A. and Nirenberg, M. (1974). Proc. natn. Acad. Sci: U.S.A., 71, 3474 - 7CrossRefGoogle Scholar

Copyright information

© The contributors 1979

Authors and Affiliations

  • S. Spector
    • 1
  • J. Shorr
    • 1
  • J. Finberg
    • 1
  • K. Foley
    • 2
  1. 1.Roche Institute of Molecular BiologyUSA
  2. 2.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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