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Endorphins in Mental Health Research pp 393–406Cite as

Palgrave Macmillan

Use of narcotic antagonists to study the role of endorphins in normal and psychiatric patients

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Abstract

This chapter reviews our studies of the effects of narcotic antagonists on sleep, respiration and pain, and on the symptoms of certain psychiatric illnesses. The recent discoveries of endogenous polypeptides that bind to opiate receptors in brain (Hughes et al. 1975; Teschemacher et al. 1975) have stimulated a search for the physiological role of these opioid substances. The pharmacological effects of opiate alkaloids provide the best available model for the effects of endorphins. Thus, since morphine and its congeners affect mood, pain appreciation, sleep, respiration, and release of pituitary hormones, these physiological functions are prime candidates for endorphin activity.

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Author information

Authors and Affiliations

  1. National Institute of Mental Health, Bethesda, Maryland, 20014, USA

    Glenn C. Davis, William E. Bunney Jr, Monte S. Buchsbaum, E. Defraites, Wallace Duncan, J. Gillin, Daniel P. van Kammen, Joel Kleinman, Dennis L. Murphy, Robert M. Post, Victor Reus & Richard J. Wyatt

Authors
  1. Glenn C. Davis
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  2. William E. Bunney Jr
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  3. Monte S. Buchsbaum
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  4. E. Defraites
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  5. Wallace Duncan
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  6. J. Gillin
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  7. Daniel P. van Kammen
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  8. Joel Kleinman
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  9. Dennis L. Murphy
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  10. Robert M. Post
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  11. Victor Reus
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  12. Richard J. Wyatt
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Editor information

Editors and Affiliations

  1. National Institute of Mental Health, Parklawn Building, 20857, Rockville, Maryland, USA

    Earl Usdin Ph.D.

  2. National Institute of Mental Health, Bethesda, Maryland, USA

    William E. Bunney Jr. M.D.

  3. Rockland Research Center, 10962, Orangeburg, New York, USA

    Nathan S. Kline M.D.

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Davis, G.C. et al. (1979). Use of narcotic antagonists to study the role of endorphins in normal and psychiatric patients. In: Usdin, E., Bunney, W.E., Kline, N.S. (eds) Endorphins in Mental Health Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04015-5_35

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