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Morphine: exogenous endorphin?

  • Yasuko F. Jacquet

Abstract

There is now increasing evidence that the multiple pharmacological actions of morphine are mediated by different sites in the central nervous system (CNS). For example, the periaqueductal gray (PAG) is now known to mediate the analgesic action of morphine (Jacquet and Lajtha, 1976), as well as the explosive motor behavior (EMB) observed following local morphine administration (Jacquet and Lajtha, 1974). Some morphine abstinence signs such as wet-dog shakes, teeth chattering, and so on, were found to be mediated by sites adjacent to the lateral ventricle (Herz, 1972), and body temperature changes induced by morphine were found to be mediated by hypothalamic sites (Lotti, 1973). However, other characteristic morphine effects such as opiate immobility have not yet been localized to any specific CNS site.

Keywords

Lateral Ventricle Opiate Receptor Mental Health Research Morphine Sulfate Stainless Steel Needle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Herz, A. (1972). In Pharmacology and the Future of Man. Proc. Sth Int. Congr. Pharmacology, San Francisco, Karger, Basel, pp. 125–39Google Scholar
  2. Jacquet, Y. F. and Lajtha, A. (1974). Science, 185, 1055–7PubMedCrossRefGoogle Scholar
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  5. Jacquet, Y. F., Klee, W. A., Rice, K. C., Iijima, I. and Minamikawa, J. (1977). Science, 198, 842–5PubMedCrossRefGoogle Scholar
  6. Lotti, V. J. (1973). In The Pharmacology of Thermoregulation. Symp. San Francisco, Karger, Basel pp. 382–94Google Scholar

Copyright information

© The contributors 1979

Authors and Affiliations

  • Yasuko F. Jacquet
    • 1
  1. 1.New York State Institute for NeurochemistryWard’s Island, New York CityUSA

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