Abstract
The electrically stimulated myenteric plexus-longitudinal muscle (MPLM) preparation is generally recognized as a reliable and sensitive bioassay for opiates and opiate-like peptides. We have recently demonstrated the release of endorphins from this preparation (Puig et al., 1977a) by using the same MPLM strip as both the source of endorphins and the bioassay to detect their opiate-like effects. We have also established the existence of cross-tolerance between the electrically induced release of endorphins and morphine (Puig et al., 1977b). Subsequently, we have studied the general characteristics of the endorphin release by investigating different parameters of electrical stimulation as well as the effects of other procedures.
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References
Adams, J. E. (1976). Pain, 2, 161 - 6
Akil, H., Mayer, D. J. and Liebeskind, J. C. (1972). C. r. hebd. Séanc. Acad. Sci. Paris, 274 , 3603-5
Akil, H., Mayer, D. J. and Liebeskind, J. C. (1976). Science, 191, 961 - 2
Beddell, C. R., Clark, R. B., Hardy, G. W., Lowe, L. A., Ubatuba, F. B., Vane, J. R., Wilkinson, S., Chang, J.-K., Cuatrecasas, P. and Miller, R. J. (1977). Proc. R. Soc. Lond., 198, 249 - 65
Brand, M., Fisher, K., Moroder, L., Wunsch, E. and Hamprecht, B. (1976). FEBS Lett., 68, 38 - 40
Burnstock, G. (1975). In Handbook of Psychopharmacology, (eds L. L. Iversen, S. D. Iversen and S. H. Snyder), 5, Plenum Press, New York, pp. 131 - 94
Bursztajn, S. and Gershon, M. D. (1977). J. Physiol., Lond., 269, 17 - 31
Craviso, G. L. and Musacchio, J. M. (1977). Soc. Neurosci. Abstr., 3. 289
Elde, R., Hökfelt, T., Johansson, O. and Terenius, L. (1976). Neuroscience, 1, 349 - 51
Frederickson, R. C. A., Nickander, R., Smithwick, R. H. and Norris, F. H. (1976). In Opiates and Endogenous Opioid Peptides, (ed. H. W. Kosterlitz) Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 239 - 46
Furness, J. B., Campbell, G. R., Gillard, S. M., Malmfors, T., Cobb, J. L. S. and Burnstock, G. (1970). J. Pharmac. exp. Ther., 174, 111 - 22
Hambrook, J. M., Morgan, B. A., Rance, M. J. and Smith, C. F. C. (1976). Nature, 262, 782 - 3
Hosobuchi, Y., Adams, J. E. and Linchitz, R. (1977). Science, 197, 183 - 6
Hughes, J. (1975). Brain Res., 88, 295 - 308
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A. and Morris, H. R. (1975). Nature, 258, 577 - 9
Jacob, J. J., Tremblay, E. C. and Colombel, M. C. (1974). Psychopharmacology, 37, 217 - 23
Koizumi, K. and Brooks, C. McC. (1972). Ergeb. PhysioL, 67, 1 - 68
Kosterlitz, H. W., Lord, J. A. H. and Watt, A. J. (1973). In Agonist and Antagonist Actions of Narcotic Analgesic Drugs, (eds H. W. Kosterlitz, H. O. J. Collier and J. E. Villareal) University Park Press, Baltimore, pp. 45 - 61
Kunze, D. L. (1972). J. PhysioL, Lona, 222, 1 - 15
Lampert, A., Nirenberg, M. and Klee, W. A. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 3165 - 7
Lane, A. C., Rance, M. J. and Walter, D. S. (1977). Nature, 269, 75 - 6
Loh, H. H., Tseng, L. F., Wei, E. and Li, C. H. (1976). Proc. natn. Acari Sci. U.S.A., 73, 2895 - 8
Marks, N., Grynbaum, A. and Neidle, A. (1977). Biochem. biophys. Res. Commun., 74, 1552 - 9
Mayer, D. J. and Hayes, R. L. (1975). Science, 188, 941 - 3
Meek, J. L., Yang, H.-Y. T. and Costa, E. (1977). Neuropharmacology, 16, 151 - 4
Miller, R. J., Chang, J.-K. and Cuatrecasas, P. (1977). Biochem. biophys. Res. Commun., 74, 1311 - 7
Pert, C. B., Pert, A., Chang, J.-K. and Fong, B. T. W. (1976). Science, 194, 330 - 2
Pert, A. and Walter, M. (1976). Life Sci., 19, 1023 - 32
Puig, M. M., Gascon, P., Craviso, G. L. and Musacchio, J. M. (1977a). Science, 195, 419 - 20
Puig, M. M., Gascon, P. and Musacchio, J. M. (1977b). Eur. J. Pharmac., 46, 205 - 6
Puig, M. M., Gascon, P., Craviso, G. L., Bjur, R. A., Matsueda, G., Stewart, J. M. and Musacchio, J. M. (1977c). Archs int. Pharmacodyn. Ther., 226, 69 - 80
Puig, M. M., Gascon, P., and Musacchio, J. M. (1978). J. Pharmac. exp. Ther., (in press)
Schulz, R. and Herz, A. (1976). Life Sci., 19, 1117 - 28
Schulz, R., Wuster, M. and Herz, A. (1977a). Life Sci., 21, 105 - 16
Schulz, R., Wuster, M., Simantov, R., Snyder, S. and Herz, A. (1977b). Eur. J. Pharmac., 41, 347 - 8
Smith, T. W., Hughes, J., Kosterlitz, H. W. and Sosa, R. P. (1976). In Opiates and Endogenous Opioid Peptides, (ed. H. W. Kostertitz). Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 57 - 62
Terenius, L. and Wahlström, A. (1975). Acta physiol, stand., 94, 74 - 81
Thoenen, H. and Tranzer, J. P. (1968). Naunyn-Schmiedebergs Arch. Pharmakol. exp. Path., 261, 271 - 88
Waterfield, A. A. and Kosterlitz, H. W. (1975). Life Sci, 16, 1787 - 92
Waterfield, A. A., Hughes, J. and Kosterlitz, H. W. (1976). Nature, 260, 624 - 5
Wei, E. and Loh, H. (1976). Science, 193, 1262 - 3
Yaksh, T. L., Yeung, J. C. and Rudy, T. A. (1976). Life Sci., 18, 1193 - 8
Zieglgansberger, W., Fry, J. P., Herz, A., Moroder, L. and Wunsch, E. (1976). Brain Res., 115, 160 - 4
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Musacchio, J.M., Puig, M.M., Craviso, G.L. (1979). Release and inactivation of opioids in the guinea pig ileum. In: Usdin, E., Bunney, W.E., Kline, N.S. (eds) Endorphins in Mental Health Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04015-5_19
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DOI: https://doi.org/10.1007/978-1-349-04015-5_19
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