Abstract
All endogenous opioids identified so far are peptides—‘endorphins’. Recently, however, endogenous opioids which might belong to another class of compounds have been detected in the blood. Both classes of endogenous opioids have been studied in this investigation. Pituitary opioid peptides were released from anterior lobe tissue on incubation between 0 and 15 °C, as reported for most of the pituitary hormones. β-endorphin and a and/or γ-endorphin were found in the incubation media. Using a hot glacial acetic acid extraction method, besides β-endorphin, an opioid with properties similar to those of the opioids detected in blood was extracted from bovine posterior pituitary lobes. To this class of endogenous opioids, apparently, also belongs a substance extracted from bovine and human milk.
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Teschemacher, H., Csontos, K., Westenthanner, A., Brantl, V., Kromer, W. (1979). Endogenous opioids: cold-induced release from pituitary tissue in vitro; extraction from pituitary and milk. In: Usdin, E., Bunney, W.E., Kline, N.S. (eds) Endorphins in Mental Health Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-04015-5_17
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DOI: https://doi.org/10.1007/978-1-349-04015-5_17
Publisher Name: Palgrave Macmillan, London
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