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Response to anaesthetic drugs in the elderly

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Drugs and the Elderly
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Abstract

It is difficult to separate the effects of disease from those of the ageing process, but as far as anaesthesia is concerned, this is an academic distinction, since disease is more common in the elderly. Anaesthetists are probably more aware of drug sensitivity than are any other physicians. Not only do they use potent drugs, but also because of the intravenous and inhalational routes, the maximum effect of these occurs within a few minutes. Furthermore, the effects of a severe adverse

Table 16.1 Drugs used by anaesthetists

reaction require immediate attention. However, these routes are themselves safety factors, as they permit a fine adjustment of dosage to the patient’s needs and thereby minimise the risk of overdosage with its accompanying dangers. Provided one appreciates the slower circulation time found in the elderly (Hunter, 1947), with proper adjustments of dosage and technique most anaesthetic drugs can be given safely to geriatric patients.

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References

  • Aladjemoff, L., Dikstein, S. and Shafrir, E. (1958). J. Pharmac. exp. Ther, 123, 43

    Google Scholar 

  • Andreasen, F. and Christensen, J. H. (1977). Br. J. clin. Pharmacol, 4, 640 P

    Article  Google Scholar 

  • Baraka, A. (1964). Br. J. Anaesth, 36, 272

    Article  Google Scholar 

  • Baraka, A. and Gabali, F. (1968). Br. J. Anaesth, 40, 89–93

    Article  Google Scholar 

  • Briscoe, W. A. (1965). In Handbook of Physiology, Section 3. Respiration, Vol. II (ed.W. O. Fenn and H. Rahn), Williams and Wilkins, Baltimore, Chapter 53, pp. 1345–79

    Google Scholar 

  • Bromage, P. R. (1954). Spinal Epidural Analgesia, Livingstone, Edinburgh

    Google Scholar 

  • Brooks, D. K. and Feldman, S. A. (1962). Anaesthesia, 17, 161

    Article  Google Scholar 

  • Cannard, T. H. and Zaimis, E. (1959). J. Physiol., Lond, 149, 112

    Article  Google Scholar 

  • Castleden, C. M., George, C. F., Marcer, D. and Hallett, C. (1977). Br. med. J, 1, 10–12

    Article  Google Scholar 

  • Collins, K. J., Dore, Caroline, Exton-Smith, A. N., Fox, R. H., MacDonald, I. C. and Woodward, Patricia M. (1977). Br. med. J, 1, 353–56

    Article  Google Scholar 

  • Crooks, J., O’Malley, K. and Stevenson, I. H. (1976). Clin. Pharmacokin, 1, 280–96

    Article  Google Scholar 

  • Dundee, J. W. (1954a). Br. J. Anaesth 26, 164–73

    Article  Google Scholar 

  • Dundee, J. W. (1954b). Br. J. Anaesth, 26, 174–81

    Article  Google Scholar 

  • Dundee, J. W. and Gray, T. C. (1953). Lancet 11, 16

    Article  Google Scholar 

  • Dundee, J. W. and Tinckler, L. F. (1952). Br. med. J, 2, 703–4

    Article  Google Scholar 

  • Dundee, J. W. and Wyant, G. M. (1974). Intravenous Anaesthesia, Churchill Livingstone, Edinburgh

    Google Scholar 

  • El-Hakim, M. S. and Baraka, A. (1963). Kasr-el-Aini J. Surg, 4, 99

    Google Scholar 

  • Fletcher, C. and Peto, R. (1977). Br. med. J, 1, 1645–58

    Article  Google Scholar 

  • Gamstorp, I. and Vinnars, E. (1961). Acta physiol. scand, 53, 142

    Article  Google Scholar 

  • Gamstorp, I. and Vinnars, E. (1963). Acta physiol. scand, 53, 48

    Article  Google Scholar 

  • Greenblatt, D. J., Allen, M. C. and Shader, R. I. (1977). Clin. Pharmac. Ther, 21, 355–61

    Google Scholar 

  • Hegarty, J. E. and Dundee, J. W. (1978). Br. J. Anaesth, 50, 78

    Google Scholar 

  • Hunter, A. R. (1947). Br. med. J, 1, 16

    Article  Google Scholar 

  • Hunter, A. R. (1956). Br. med. J, 2, 919

    Article  Google Scholar 

  • Richards, D. W. (1965). In Handbook of Physiology, Section 3. Respiration, Vol. II (ed. W. O. Fenn and H. Rahn), Williams and Wilkins, Baltimore, Chapter 66, pp. 1525–29

    Google Scholar 

  • Skegg, D. C. G., Doll, R. and Perry, J. (1977). Br. med. J 1, 1561–63

    Google Scholar 

  • Skivington, M. A. (1973). In Muscle Relaxants, Vol. I, (ed. W. W. Mushin) Saunders, London, pp. 109–16

    Google Scholar 

  • Stovner, J., Theodorsen, L. and Bjelke, E. (1971a). Br. J. Anaesth, 43, 385

    Article  Google Scholar 

  • Stovner, J., Theodorsen, L. and Bjelke, E. (1971b). Br. J. Anaesth, 43, 953

    Article  Google Scholar 

  • Stovner, J., Theodorsen, L. and Bjelke, E. (1972). Br. J. Anaesth, 44, 373

    Article  Google Scholar 

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© 1979 J. Crooks and I. H. Stevenson

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Dundee, J.W. (1979). Response to anaesthetic drugs in the elderly. In: Crooks, J., Stevenson, I.H. (eds) Drugs and the Elderly. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03813-8_16

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