Substance P: a historical account

  • F. Lembeck
Part of the Biological Council book series


Substance P (SP) was first detected (von Euler and Gaddum, 1931) during a search for acetylcholine in alcoholic extracts of brain and intestine of the rabbit. These extracts contracted the isolated intestine and lowered the rabbit’s blood pressure, but contrary to expectation these actions were resistant to atropine. It soon became clear that the extracts owed their biological activity not to acetylcholine, histamine or derivatives of adenylic acid, but to material of polypeptide nature (von Euler, 1936). The name ‘Substance P’ appeared first in a paper by Gaddum and Schild (1934).


Aqueous Phase Aqueous Extract Total Lipid Extract Chloroform Phase Peripheral Nerve Ending 
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  1. Abood, L. G. and Hoss, W. P. (1975). Psychopharmac. Commun., 1, 29–35Google Scholar
  2. Folch, J., Lees, M. and Stanley, G. H. S. (1957). J. boil. Chem., 226, 497–509Google Scholar
  3. Gaddum, J. H. (1964). J. Physiol., Lond., 172, 207CrossRefGoogle Scholar
  4. Geipert, F., Lembeck, F. and Sprössler, B. (1969). Arch. exp. Path. Pharmak., 265, 225–32CrossRefGoogle Scholar
  5. Heizmann, A., Lembeck, F. and Seidel, G. (1966). Arch. exp. Path. Pharmak., 253, 265–79Google Scholar
  6. Otsuka, M., Konishi, S. and Takahashi, T. (1975). Fedn Proc., 34, 1922–28Google Scholar
  7. Rouser, G. (1967). Meth. Enzymol., 10, 402–30Google Scholar
  8. Soto, E. F., Pasquini, J. M., Placido, R. and La Torre, J. L. (1969). J. Chromatog., 41, 400–09CrossRefGoogle Scholar

Copyright information

© Institute of Biology Endowment Trust Fund 1978

Authors and Affiliations

  • F. Lembeck
    • 1
  1. 1.Institut für experimentelle und klinische Pharmakologie der Universität GrazUniversitätsplatz 4GrazAustria

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