Abstract
Hypothalamic peptides appear to serve a variety of functions. While many exert classical endocrine effects, certain of them appear also to cause alterations in behaviour, alterations in behavioural responses to drugs, or alterations in systems that themselves affect behaviour. Such actions are the subject of this chapter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arimura, A., Sato, H., Dupont, A., Nishi, N. and Schally, A. V. (1975). Science, 189, 1007–09
Arimura, A., Smith, W. D. and Schally, A. V. (1976). Endocrinology, 98, 540–43
Barbeau, A., Burnett, C., Strother, E. and Butterworth, R. F. (1975). Clin. Res., 23, 641A
Barlow, T. S., Cooper, B. R., Breese, G. R., Prange, A. J., Jr. and Lipton, M. A. (1975) Neurosci Abst, 1, 334
Benkert, O. (1975). In Hormones, Homeostasis and the Brain (ed. W. H. Gispen, T. B. van Wimersma Greidanus, B. Bohus and D. de Wied), Progress in Brain Research 42, Elsevier, Amsterdam
Bird, E. D., Chiappa, S. A. and Fink, G. (1976). Nature, 260, 536–38
Bissette, G., Nemeroff, C. B., Loosen, P. T., Prange, A. J., Jr and Lipton, M. A. (1976a). Pharmac. Biochem. Behay., 5 (suppl. 1), 135–38
Bissette, G., Nemeroff, C. B., Loosen, P. T., Prange, A. J., Jr and Lipton, M. A. (1976b). Nature, 262, 607–09
Brambilla, F., Rovere, C., Guastalla, A., Guerrini, A. and Riggi, F. (1976). Acta psychiat. stand., 54, 131–45
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J. and Guillemin, R. (1973) Science, 179, 77–79
Breese, G. R., Cott, J. M., Cooper, B. R., Prange, A. J., Jr and Lipton, M. A. (1974a). Life Sci., 14, 1053–63
Breese, G. R., Cooper, B. R., Prange, A. J., Jr, Cott, J. M., and Lipton, M. A. (1974b). In The Thyroid Axis, Drugs and Behavior, (ed. A. J. Prange, Jr) Raven, Press, New York
Breese, G. R., Cott, J. M., Cooper, B. R., Prange, A. J., Jr, Lipton, M. A. and Plotnikoff, N. P. (1975). J. Pharmac exp. Ther., 193, 11–22
Brown, M. and Vale, W. (1975a). Endocrinology, 90, 1333–36
Brown, M. and Vale, W. (1975b). Endocrinology, 97, 1151–1156
Brown, M., Villarreal, J. and Vale, W. (1976) Metabolism, 25 (suppl. 1), 1459–63
Brownstein, M. J., Palkovits, M., Saavedra, J. M., Bassiri, R. M. and Utiger, R. D. (1974). Science, 185, 267–69
Brownstein, M. J., Arimura, A., Sato, H., Schally, A. V. and Kizer, J. S. (1975) Endocrinology, 96, 1456–61
Brownstein, M. J., Palkovits, M., Saavedra, J. M. and Kizer, J. S. (1976a). In Frontiers in Neuroendocrinology, Vol. 4 (ed. L Martini and W. F. Ganong), Raven Press, New York, pp. 1–24
Brownstein, M. J., Mroz, E. A., Kizer, J. A., Palkovits, M. and Leeman, S. E. (1976b). Brain Res., 116, 299–305
Carraway, R. and Leeman, S. E. (1973). J. biol. Chem., 248, 6851–54
Carraway, R. and Leeman, S. E. (1975). J. biol. Chem., 250, 1907–18
Chang, M. M., Leeman, S. E. and Niall, H. D. (1971). Nature new Biol., 232, 86–89
Chase, T. N., Woods, A. C., Lipton, M. A. and Morris, C. E. (1974). Archs Neurok, 31, 55–56
Cohn, M. L. and Cohn, M. (1975): Fedn Proc., 34, 738
Collu, R., Clermont, M. J., Letarte, J., Leboeuf, F. and Ducharme, J. R. (1975). In Hypothalamus and Endocrine Functions (ed. F. Labrie, J. Meites and G. Pelletier), Plenum Press, New York, p. 479
Constantinidis, J., Geissbuhler, F., Gaillard, J. M., Hovaguimian, T. H. and Tissot, R. (1974). Experientia, 30, 1182
Coppen, A., Peet, M., Montgomery, S. and Bailey, J. (1974). Lancet, i, 433–35
Cott, J. M., Breese, G. R., Cooper, B. R., Barlow, T. S. and Prange, A. J., Jr. (1976): J. Pharmac. exp. Ther., 196, 594–604
Cott, J. M. and Engel, J. (1977). Psychopharmacology, (in press).
Czernichow, P., Dauzet, M. C., Broyer, M. and Rappoport, R. (1976). J. din. Endocr. Metab., 43, 630–37
de Wied, D. (1974). In Hormones and Brain Function (ed. K. Lissak), Plenum Press, New York
de Wied, D., Witter, A. and Greven, H. M. (1975). Biochem. Pharmac., 24, 1463–68
de Wied, D., and Gispen, W. H. (1977). In Peptides in Neurobiology (ed. H. Gainor), Plenum Press, New York, (in press)
Ehrensing, R. H. and Kastin, A. J. (1974). Archs. gen. Psychiat, 30, 63–65
Emlen, W., Segal, D. S. and Mandell, A. J. (1972). Science, 175, 79–82
Everett, G. M. (1966). Excerpta Medica Int. Congr. Series, No. 122, Milan
Friedman, E., Friedman, J. and Gershon, S. (1974). Science, 182, 831–32
Furlong, F. W., Brown, G. M. and Beeching, M. F. (1976). Am. J. Psychiat., 133, 1187–90
Green, A. R. and Grahame-Smith, D. C. (1974). Nature, 251, 524–26
Hökfelt, T., Fuze, K., Goldstein, M. and Johansson, O. (1973). Acta physiol scand, 89, 286–88
Hükfelt, T., Efendić, S., Johansson, O., Luft, R., and Arimura, A. (1974). Brain Res., 80, 165–69
Hökfelt, T., Meyerson, B., Nilsson, G., Pernow, B. and Sachs, C. (1976). Brain Res., 104, 181–86
Hollander, C. S., Mitsuma, T. and Nilhei, N. (1972). Lancet, i, 609
Horita, A. and Carino, M. A. (1975). Psychopharmac. Commun., 1, 403–14
Horst, W. D. and Spirt, N. (1974). Life Sal, 15, 1073–82
Huey, L. Y., Janowsky, D. S., Mandell, A. J., Judd, L. L. and Pendery, M. (1975). Psychopharmac. Bull., 11 (1), 24–27
Huidobro-Toro, J. P., Scotti de Carolis, A. and Longo, V. G. (1974). Pharmac. Biochem. Behay., 2, 105–09
Huidobro-Toro, J. P., Scotti de Carolis, A. and Longo, V. G. (1975). Pharmac. Biochem. Behay., 3, 235–42
Inanaga, K., Nakano, T., Nagata, T. and Tanaka, M. (1975a). Kurume med J., 22, 159–68
Inanaga, K., Ohshima, M., Nagata, T. and Yamauchi, I. (1975b). Folia psychiat. neurol. jap., 29, 197–205
Jackson, I. M. D. and Reichlin, S. (1974a). Endocrinology, 95, 816–24
Jackson, I. M. D. and Reichlin, S. (1974b). Life Set, 14, 2259–66
Jones, C. N., Grant, L. D., Prange, A. J., Jr and Breese, G. R. (1975). Neurosci. Abstr., 1, 246
Kastin, A. J. and Barbeau, A. (1972). Can. med. Ass. J., 107, 1079–81
Kastin, A. J., Plotnikoff, N. P., Schally, A. V. and Sandman, C. A. (1976). In Reviews of Neuroscience 2, (ed. S. Ehrempreis and I. J. Kopin), Raven Press, New York
Keller, H. H., Bartholini, G. and Pletscher, A. (1974). Nature, 248, 528–29
King, C. D. (1975). Pharmacologist, 17, 211
Kirkegaard, C., Norlem, N., Lauridsen, B. U., Bjorum, N. and Christiansen, C. (1975). Archs. gen. Psychiat., 32, 1115–18
Knowles, F. (1974). In Essays on the Nervous System (ed. R. Bellaris and E. G. Gray), Clarendon Press, Oxford
Kobayashi, R. M., Brown, M. and Vale, W. (1977). Brain Res., (in press)
Kraemer, G. W., Mueller, R., Breese, G. R., Prange, A. J., Jr, Lewis, J. K., Morrison, H. and McKinney, W. T., Jr (1976). Pharmac. Biochem. Behay., 4, 709–12
Lakke, J. P. W. F., van Praag, H. M., van Twist, R., Doorenbos, H. and Witt, F. G. J. (1974). Clin. Neurol. Neurosurg, 3 (4), 1–5
Leeman, S. E. and Carraway, R. E. (1977). In Peptides in Neurobiology (ed. H. E. Gainor) Plenum Press, New York, (in press)
Lipton, M. A., Prange, A. J., Jr., Nemeroff, C. B., Breese, G. R. and Wilson, L C. (1977). In Neuroregulators and Hypotheses of Psychiatric Disorders (ed. E. Usdin, D. A. Hamburg and J. Barchas), Oxford University Press, New York
Loosen, P. T., Prange, A. J., Jr, Wilson, I. C. and Lara, P. P. (1976). Pharmac. Biochem. Behay., 5 (suppl. 1), 95–101
Loosen, P. T., Prange, A. J., Jr, Wilson, I. C., Lara, P. P. and Pettus, C. (1977). Psychoneuroendocrinology, (in press).
Maeda, K., Kato, Y., Ohgo, S., Chihara, K., Yashimoto, Y., Yamaguchi, N., Korumaru, S., and Imura, H. (1975). J. clin. Endocr. Metab., 40, 501–05
Makino, T., Carraway, R., Leeman, S. E. and Greep, R. O. (1973). Soc. Study Repro., 26
Malick, J. B. (1976). Pharmac. Biochem. Behay., 5, 665–69
Martin, J. B., Renaud, L. P. and Brazeau, P. (1975). Lancet, i, 393–95
Matsuo, H., Baba, Y., Nair, R. M. C., Arimura, A. and Schally, A. V. (1971). Biochem. biophys. Res Commun., 43, 1334–39
McCann, S. M., Fawcett, C. P. and Krulich, L. (1974). In MTP International Review of Science Series I Physiology, Vol. 5 (ed. S. M. McCann), Butterworth, London
McCaul, J. S., Cassell, K. J. and Stern, G. M. (1974). Lancet, ii, 735
McEwen, B. S. (1976). In Basic Neurochemistry (ed. G. J. Siegel, R. W. Albers, R. Katzman and B. W. Agranoff), Little, Brown & Co., Boston
Metcalf, G. (1974). Nature, 252, 310–11
Monahan, M., Rivier, J., Burgus, R., Amoss, M., Blackwell, R., Vale, W. and Gùilhnéin, R. (1971). C. r. Séant Soc. Biol., 273. 508–10
Mortimer, G. H., McMeilly, A. S., Fisher, R. A., Murray, M. A. F. and Besser, G. M. (1974). Br. med J., 4, 617–21
Moss, R. L. (1975). In Reproductive Behaviour (ed. W. A. Sadler and W. Montagna), Plenum Press, New York
Moss, R. L. and McCann, S. M. (1973) Science, 181, 177–79
Moss, R. L., McCann, S. M. and Dudley, C. A. (1975). In Homeostatsis, and the Brain (ed. W. H. Gispen, Tj. B. van Wimersma Greidanus, B. Bohus and D. de Wied), Elsevier, Amsterdam
Moss, R. W. and Foreman, M. M. (1976). Neuroendocrinology, 20, 176–81
Nagai, K. and Frohman, L. A. (1976). Life Sci., 19, 273–80
Nair, R. M. G., Kastin, A. J. and Schally, A. V. (1971a). Biochem. biophys. Res. Commun., 43, 1376–81
Nair, R. M. G., Redding, T. W. and Schally, A. V. (1971b). Biochemistry, 10, 3621–24
Nair, R. M. G., Kastin, A. J. and Schally, A. V. (1972) Biochem. biophys. Res. Commun., 47, 1420–25
Nemeroff, C. B., Prange, A. J., Jr., Bissette, G., Breese, G. R. and Lipton, M. A. (1975) Psychopharmac. Commun., 1, 305–17
Nemeroff, C. B., Bissette, G., Prange, A. J., Jr, Loosen, P. T. and Lipton, M. A. (1976). Proc. Endo. Soc. A. Mtg, 312
Nemeroff, C. B., Bissette, G., Prange, A. J., Jr and Lipton, M. A. (1977a). Proc. 34th Ann. Meeting Psychosomatic Med. Soc. Abstr.
Nemeroff, C. B., Diez, J. A., Bissette, G., Harrell, L. E., Prange, A. J., Jr and Lipton, M. A. (1977b): Pharmac. Biochem. Behay., 6, 467–69
Nemeroff, C. B., Bissette, G., Loosen, P. T., Barlow, T. S., Prange, A. J., Jr and Lipton, M. A. (1977c): Brain Res., 128, 485–98
Nemeroff, C. B., Bissette, G., Loosen, P. T., Burnett, G. B., Prange, A. J., Jr and Lipton, M. A. (1977d). Int. Soc. Psychoneuroendocrinology, Eighth Annual Meeting, Atlanta (abstract)
North, R. B., Harik, S. I., and Snyder, S. H. (1973). Brain Res, 63, 435–39
Olivier, C., Eskay, R. L, Ben-Jonathan, N. and Porter, J. C. (1974). Endocrinology, 96, 540–46
Orci, L., Baetens, O., Rufener, C., Brown, M., Vale, W. and Guillemin, R. (1976). Life Sci., 19, 559–62
Otsuki, M., Dakoda, M. and Baba, S. (1973). J. clin. Endocr. Metab., 36, 95–102
Ozawa, J. and Shishiba, J. (1975). Endocr. Japon, 22, 269–75
Pfaff, D. S. (1973). Science, 182, 1148–49
Piva, F. and Steiner, H. (1972). Front. Horm. Res, 1, 11–21
Plotnikoff, N. P., Kastin, A. J., Anderson, M. S. and Schally, A. V. (1971). Life Sci, 10, 1279–83
Dlotnikoff, N. P., Prange, A. J., Jr, Breese, G. R., Anderson, M. S. and Wilson, L C. (1972). Science, 178, 417–18
Plotnikoff, N. P. and Kastin, A. J. (1974). Archs in Pharmacodyn. Ther., 211, 211–14
Plotnikoff, N. P., Prange, A. J., Jr, Breese, G. R. and Wilson, L C. (1974a). Life Sci., 14, 1271–78
Plotnikoff, N. P., Prange, A. J., Jr, Breese, G. R., Anderson, M. S., and Wilson, I. C. (1974b). In The Thyroid Axis, Drugs, and Behavior (ed. A. J. Prange, Jr), Raven Press, New York
Plotnikoff, N. P., Minard, F. N., and Kastin, A. J. (1974c). Neuroendocrinology, 14, 271–79
Plotnikoff, N. P., Kastin, A. J. and Schally, A. V. (1974d). Pharmac Biochem. Behay., 2, 693–96
Plotnikoff, N. P., Breese, G. R. and Prange, A. J., Jr (1975). Pharmac. Biochem. Behay., 3, 665–670
Plotnikoff, N. P. and Kastin, A. J. (1976). Life Sci., 18, 1217–22
Plotnikoff, N. P., White, W. F., Kastin, A. J. and Schally, A. V. (1976): Life Sci., 17, 1685–92
Posner, B. L. (1975). Can. J. Physiol. Pharmac., 53, 689–703
Prange, A. J., Jr (1977). In Phenomenology and Treatment of Depression (ed. W. E. Fann, L. Karacan, A. D. Porkorny, and R. L. Williams), Spectrum, New York, pp. 1–15
Prange, A. J. Jr, Wilson, I. C., Rabon, A. M. and Lipton, M. A. (1969): Amer. J. Psychiat, 126 457–69
Prange, A. J., Jr, Wilson, I. C., Knox, A., McClane, T. K., and Lipton, M. A. (1970). Amer. J. Psychiat., 127, 190–99
Prange, A. J., Jr and Wilson, I. C. (1972). Psychopharmacologia, 26, 82
Prange, A. J., Jr, Wilson, I. C., Lara, P. P., Alltop, L. B. and Breese, G. R. (1972). Lancet, ii, 999–1002
Prange, A. J., Jr, Breese, G. R., Cott, J. M., Martin, B. R., Cooper, B. R., Wilson, I. C. and Plotnikoff, N. P. (1974). Life Sei., 14, 447–55
Prange, A. J., Jr, Breese, G. R., Jahnke, G. D., Martin, B. R., Cooper, B. R., Cott, J. M., Wilson, I. C., Alltop, L. B., Lipton, M. A., Bissette, G., Nemeroff, C. B. and Loosen, P. T. (1975a) Life Sci., 16, 1907–14
Prange, A. J., Jr, Breese, G. R., Wilson, I. C. and Lipton, M. A. (1975b). In Anatomical Neuroendocrinology (ed. W. E. Stumpf and L. D. Grant), S. Karger, Basel, pp. 357–66
Prange, A. J., Jr, Nemeroff, C. B., Lipton, M. A., Breese, G. R. and Wilson, I. C. (1978). In Handbook of Psychopharmacology (ed. L. L. Iversen, S. D. Iversen and S. H. Snyder), Plenum Press, New York, pp. 1–117
Rakic, P. (1975) Neurosci. Res. Prog, 13(3)
Re, R. N., Kourides, I. A., Ridgeway, E. C., Weintraub, B. D., and Maloot, F. (1976). J. Clin. Endocr. Metab., 43, 338–46
Reichlin, S., Saperstein, R., Jackson, I. M. D., Boyd, A. E. and Patel, Y. (1976). A. Rev. Physiol 38, 389–424
Reigle, T. J., Avni, J., Platz, P., Schidkraut, J. J. and Plotnikoff, N. P. (1974). Psychopharmacologia, 37, 1–6
Rezek, M., Havlicek, V., Hughes, K. R. and Friesen, H. (1976). Neuropharmacology, 15, 499–504
Rivier, C., Brown, M. and Vale, W. (1977). Endocrinology, 100, 751–54
Rufener, C., DuBois, M. P., Malaisse-Lagae, F. and Orci, L. (1975). Diabetologia, 11, 321–24
Said, S. T. and Rosenberg, R. N. (1976). Science, 192, 907–08
Schenkel-Hulliger, L., Koella, W. P., Hartmann, A. and Maitre, L. (1974). Experientia, 30, 1168–70
Schwarzstein, L, Aparico, N. J., Turner, D., Calamera, J. C., Mancini, R. and Schally, A. V. (1975). Fert. Steril., 26 (4), 331–36
Segal, D. S. and Mandell, A. J. (1974). In The Thyroid Axis, Drugs, and Behavior (ed. A. J. Prange, Jr) Raven Press, New York
Simon, P., Goujet, M. A. and Boissier, J. R. (1975). Therapie, 30, 485–97
Snyder, S. H. (1976). Am. J. Psychiat., 133, 197–202
Spirtes, M. A., Kostrezewa, R. M., Plotnikoff, N. P. and Kastin, A. J. (1975). Neurosci. Abstr., 1, 241
Stern, P. and Hadzovic, J. (1973). Archy. int Pharmacodyn. Thér., 202, 259–62
Takahashi, S., Kondo, H., Yoshimura, M. and Ochi, Y. (1974). Folia psychia1 neurol. jap. 28 (4), 355–65
Terry, L. C., Willoughby, J. O., Brazeau, P., Martin, J. B. and Patel, Y. (1976). Science, 192, 565–66
Tiwary, C. N., Rosenbloom, A. L., Robertson, M. F. and Parker, J. C. (1975). Pediatrics, 56, 119–21
Tyndel, M. (1974). Can. Psychiat. Asso. J., 19, 21–24
Uhl, G., Bennett, J. P. and Snyder, S. I. (1977). Brain Res., 130, 299–314
Vale, W. and Rivier, C. (1975). In Handbook of Psychopharmacology (ed. L. L. Iversen, S. D. Iversen and S. H. Snyder), Plenum Press, New York
Vale, W., Rivier, C. and Brown, M. (1977). A. Rev. Physiol., 39, 473–527
Vanderhaegen, J. J., Signeay, J. C. and Gepts, W. (1975) Nature, 257, 604
Vinik, A. I., Kalk, W. J., McLaren, H., Hendricks, S., and Pimstone, B. L. (1975). J. Clin. Endocr. Metab., 40, 509–11
von Euler, U.S. and Gaddem, J. H. (1931). J. Physiol, Land., 72, 74–87
Wallis, M. (1975). Biol. Rev., 50, 35–98
Wei, E., Sigel, S., Loh, H. and Way, E. L. (1975). Nature, 253, 739–40
Weingold, L. P., Lachin, I. M., Bell, A. H. and Coxe, R. C. (1968). J. abnorm. Psychol, 72, 195–97
White, R. P. and Beale, J. S. (1975). Neurosci. Abstr., 1, 727
Whybrow, P. C., Coppen, A., Prange, A. J., Jr, Noguera, R. and Bailey, J. R. (1972). Archy gen. Psychiat., 26, 242–45
Wilber, J. F., Montoya, E., Plotnikoff, N. P., White, W. F., Gendrich, R., Renaud, L. P. and Martin, J. B. (1976). Recent Prog Horm. Res., 1 117–53
Wilson, I. C., Prange, A. J., Jr, McClane, T. K., Rabon, M. A. and Lipton, M. A. (1970). New Eng. J. Med., 282, 1063–1067
Wilson, I. C., Lara P. P. and Prange, A. J., Jr. (1973). Lancet, ii, 43–44
Winokur, A. and Utiger, R. D. (1974). Science, 185, 265–66
Woodruff, R. A., Jr, Guze, S. B., Clayton, P. J. and Carr, D. (1973). Archy gen. Psychiat., 28, 97–100
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1978 Institute of Biology Endowment Trust Fund
About this chapter
Cite this chapter
Prange, A.J., Nemeroff, C.B., Loosen, P.T. (1978). Behavioural effects of hypothalamic peptides. In: Hughes, J. (eds) Centrally Acting Peptides. Biological Council. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03668-4_7
Download citation
DOI: https://doi.org/10.1007/978-1-349-03668-4_7
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-03670-7
Online ISBN: 978-1-349-03668-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)