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Centrally Acting Peptides pp 85–97Cite as

Palgrave Macmillan

Comparative features of enkephalin and neurotensin in the mammalian central nervous system

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Part of the book series: Biological Council

Abstract

Interest in recent years has centred on small peptides as possible neurotransmitters or neuromodulators in the central nervous system (CNS). Some of these, such as somatostatin and thyrotropin releasing hormone (TRH), were first explored as hypothalamic releasing factors for pituitary hormones. Vasoactive intestinal peptide (VIP) and gastrin were identified as gastrointestinal modulators and angiotensin has been well known as a regulator of vascular muscle activity and adrenal gland secretion. Substance P and neurotensin were first characterised as brain peptides of unknown function; enkephalin as the brain’s endogenous opioid peptide. Most ‘neuropeptides’ appear to be associated with cells that have arisen embryologically from neuroectodermal elements and which are localised in the intestinal system or the CNS. Enkephalin and neurotensin will constitute the major focus of this chapter.

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Author information

Authors and Affiliations

  1. Departments of Pharmacology and Experimental Therapeutics, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Solomon H. Snyder, George R. Uhl & Michael J. Kuhar

Authors
  1. Solomon H. Snyder
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  2. George R. Uhl
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  3. Michael J. Kuhar
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Imperial College of Science and Technology, University of London, UK

    J. Hughes Ph.D.

Copyright information

© 1978 Institute of Biology Endowment Trust Fund

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Cite this chapter

Snyder, S.H., Uhl, G.R., Kuhar, M.J. (1978). Comparative features of enkephalin and neurotensin in the mammalian central nervous system. In: Hughes, J. (eds) Centrally Acting Peptides. Biological Council. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03668-4_6

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