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Comparative features of enkephalin and neurotensin in the mammalian central nervous system

  • Solomon H. Snyder
  • George R. Uhl
  • Michael J. Kuhar
Part of the Biological Council book series

Abstract

Interest in recent years has centred on small peptides as possible neurotransmitters or neuromodulators in the central nervous system (CNS). Some of these, such as somatostatin and thyrotropin releasing hormone (TRH), were first explored as hypothalamic releasing factors for pituitary hormones. Vasoactive intestinal peptide (VIP) and gastrin were identified as gastrointestinal modulators and angiotensin has been well known as a regulator of vascular muscle activity and adrenal gland secretion. Substance P and neurotensin were first characterised as brain peptides of unknown function; enkephalin as the brain’s endogenous opioid peptide. Most ‘neuropeptides’ appear to be associated with cells that have arisen embryologically from neuroectodermal elements and which are localised in the intestinal system or the CNS. Enkephalin and neurotensin will constitute the major focus of this chapter.

Keywords

Vasoactive Intestinal Peptide Thyrotropin Release Hormone Opioid Peptide Opiate Receptor Zona Incerta 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Biology Endowment Trust Fund 1978

Authors and Affiliations

  • Solomon H. Snyder
    • 1
  • George R. Uhl
    • 1
  • Michael J. Kuhar
    • 1
  1. 1.Departments of Pharmacology and Experimental Therapeutics, and Psychiatry and Behavioral SciencesJohns Hopkins University School of MedicineBaltimoreUSA

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