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Electrophysiological analysis of peptide actions in neural tissue

  • Leo P. Renaud
  • Ante Padjen
Part of the Biological Council book series

Abstract

The functional characterisation of endogenous neural substances demands the concerted efforts of investigators in numerous disciplines, a point that is adequately illustrated in the proceedings of this symposium. Over the past 20 years, electrophysiological techniques have provided a most valuable insight into the function of diverse excitable tissues, especially the nervous system. Because of its excellent time resolution, relatively simple technology and often unequivocal interpretation, electrophysiology has continued to be a most useful method for real-time monitoring of neuronal activity especially at the cell and/or membrane level. Electrophysiological techniques have been used to elucidate basic mechanisms of synaptic transmission, and continue to be of major importance in the sometimes frustrating analysis of complex neural organisation and behaviour. A large portion of our knowledge of central nervous system (CNS) pharmacology is derived from the analysis of drug effects on the electrical activity of the nervous system.

Keywords

Median Eminence Preoptic Area Central Neuron Ventral Root Medial Preoptic Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abrash, L., Walter, R. and Marks, N. (1971). Experientia, 27, 1352–53PubMedCrossRefGoogle Scholar
  2. Arnauld, E., Dufy, B. and Vincent, J. D. (1975). Brain Res., 100, 315–25PubMedCrossRefGoogle Scholar
  3. Auerback, A. A. and Bennett, M. V. L. (1961). J. gen. Physiol., 53, 183–210CrossRefGoogle Scholar
  4. Barker, J. L. (1976). Physiol. Rev., 56, 435–52PubMedGoogle Scholar
  5. Barker, J. L. (1977). In Peptides in Neurobiology (ed. H. Gainer), Plenum Press, New York (in press)Google Scholar
  6. Barker, J. L., Crayton, J. W. and Nicoll, R. A. (1971). Brain Res., 33, 353–66PubMedCrossRefGoogle Scholar
  7. Barker, J. L. and Gainer, H. (1975a). Brain Res., 84, 461–77PubMedCrossRefGoogle Scholar
  8. Barker, J. L. and Gainer, H. (1975b). Brain Res., 84, 479–500PubMedCrossRefGoogle Scholar
  9. Barker, J. L., Nicoll, R. A. and Padjen, A. (1975). J. Physiol., Lond., 245, 521–36PubMedPubMedCentralCrossRefGoogle Scholar
  10. Barker, J. L. and Smith, T. G. (1977). In Approaches to the Cell Biology of Neurons (ed. W. M. Cowan and J. A. Ferrendelli). Society for Neuroscience, Bethesda, Md. pp. 340–73Google Scholar
  11. Bennett, G., Edwardson, J., Holland, D., Jeffcoate, S. and White, N. (1975). Nature, 257, 323–25PubMedCrossRefGoogle Scholar
  12. Bloom, F. E. (1972). Neurosci.Res.Progm Bull., 10, 122–251Google Scholar
  13. Bloom, F. E. (1974). Life Sci., 14, 1819–34PubMedCrossRefGoogle Scholar
  14. Bloom, F. E. (1975). In Pre- and Postsynaptic Receptors (ed. E. Usdin and W. E. Bunney Jr), Marcel Dekker, New York, pp. 67–86Google Scholar
  15. Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J. and Guillemin, R. (1973). Science, 179, 77–79PubMedCrossRefGoogle Scholar
  16. Breese, G. R., Cott, J. M., Cooper, B. R., Prange, A. J. Jr., Lipton, M. A. and Plotnikoff, N. P. (1975) J. Pharmac. exp. Ther., 193, 11–22Google Scholar
  17. Buranarugsa, P. and Hubbard, J. I. (1976). Proc. Univ.Otago med.Sch., 54, 3–4Google Scholar
  18. Burnstock, G. (1976). Neuroscience, 1, 239–48PubMedCrossRefGoogle Scholar
  19. Burt, D. R. and Snyder, S. H. (1975). Brain Res., 93, 309–28PubMedCrossRefGoogle Scholar
  20. Calvillo, O., Henry, J. L. and Neuman, R. (1974). Can.J.Physiol.Pharmac., 52, 1207–11CrossRefGoogle Scholar
  21. Cross, B. A., Dyball, R. E. J., Dyer, R. G., Jones, C. W., Lincoln, D. W., Morris, J. F. and Pickering, B. T. (1975). Recent Prog.Horm. Res., 31, 243–294PubMedGoogle Scholar
  22. Cross, B. A. and Green, J. D. (1959). J.PhysioL, Lond., 148, 554–69PubMedPubMedCentralCrossRefGoogle Scholar
  23. Curtis, D. R. (1964). In Physical Techniques in Biological Research, Vol. V. (ed. W. L. Nastuk), Academic Press, New York and London, pp. 144–90Google Scholar
  24. Curtis, D. R., Game, C. J. A., Johnston, G. A. R. and McCulloch, R. M. (1974). Brain Res., 70, 493–99PubMedCrossRefGoogle Scholar
  25. Dale, H. A. (1935). Proc. R. Soc. Med., 28, 318–32Google Scholar
  26. Davidoff, R. A. and Sears, E. S. (1974). Neurology, 24, 957–63PubMedCrossRefGoogle Scholar
  27. Davies, J. and Dray, A. (1976). Brain Res., 107, 623–27PubMedCrossRefGoogle Scholar
  28. Davies, J. and Watkins, J. C. (1974). Brain Res., 70, 501–05PubMedCrossRefGoogle Scholar
  29. Dreifuss, J. J. and Kelly, J. S. (1972). J.Physiol., Lond., 220, 87–103PubMedPubMedCentralCrossRefGoogle Scholar
  30. Dyball, R. E. J. (1974). J.Endocr., 60, 135–43PubMedCrossRefGoogle Scholar
  31. Dyer, R. G. and Dyball, R. E. J. (1974). Nature, 252, 486–488PubMedCrossRefGoogle Scholar
  32. Eccles, J. C. (1964). The Physiology of Synapses. Springer, Gottingen, Berlin and HeidelbergCrossRefGoogle Scholar
  33. Epstein, A. N., Fitzsimmons, J. F. and Johnson, A. F. (1973). J.Physiol., Lond., 230, 42–43 PGoogle Scholar
  34. Felix, D. and Akert, K. (1974). Brain Res., 76, 350–53PubMedCrossRefGoogle Scholar
  35. Fischer-Ferraro, C., Nahmod, V. E., Goldstein, D. J. and Finkielman, S. (1971). J. exp. Med., 133, 353–61PubMedPubMedCentralCrossRefGoogle Scholar
  36. Fitzsimons, J. T. (1975). In Hormones, Homeostasis and the Brain; Progress in Brain Research, Vol. 42, (ed. W. H. Gispen, T. B. van Wimersma Greidanus, B. Bonus and D. de Wied), Elsevier, Amsterdam, pp. 215–33Google Scholar
  37. Florey, E. (1967). Fedn Proc., 26, 1164–78Google Scholar
  38. Foote, S. L., Freedman, R. and Oliver, A. P. (1975). Brain Res., 86, 229–242PubMedCrossRefGoogle Scholar
  39. Fotherby, K. J., Morrish, N. J. and Ryall, R. W. (1976). Brain Res., 113, 210–13PubMedCrossRefGoogle Scholar
  40. Freedman, R., Hoffer, B. J., Puro, D. and Woodward, D. J (1976). Br.J.Pharmac., 57, 603–05CrossRefGoogle Scholar
  41. Fuxe, K., Ganten, D., Hökfelt, T. and Bolme, P. (1976). Neurosci. Lett., 2, 229–34PubMedCrossRefGoogle Scholar
  42. Ganten, D., Granger, P., Ganten, U., Boucher, R. and Genest, J. (1972). In Hypertension (ed. J. Genest and K. Koiw), Springer-Verlag, Berlin, pp. 423–32Google Scholar
  43. Ganten, D., Hutchinson, J. S., Schelling, J. P., Ganten, U. and Fischer, H. (1976). Clin.Exp. Pharmac.PhysioL, 2, 103–126CrossRefGoogle Scholar
  44. Ganten, D., Marques-Julio, A., Granger, P., Hayduk, K., Karminky, K. P., Boucher, R. and Genest, J. (1971a). Am.J.PhysioL, 221, 1733–1737PubMedGoogle Scholar
  45. Ganten, D., Minnich, J., Granger, P., Hayduk, K., Brecht, H. M., Barbeau, A., Boucher, R. and Genest, J. (1971b). Science, 173, 64–65PubMedCrossRefGoogle Scholar
  46. Goldstein, D. J., Diaz, A., Finkielman, S., Nahmod, V. E. and Fischer-Ferraro, C. (1972). J.Neurochem., 19, 2451–52PubMedCrossRefGoogle Scholar
  47. Green, J. D. (1969). In The Hypothalamus (ed. W. Haymaker, E. Anderson and W. J. H. Nauta), Thomas, Springfield, Ill., pp. 276–310Google Scholar
  48. Gronan, R. J. and York, D. H. (1976). NeurosciAbstr., 2, 426Google Scholar
  49. Halasz, B. (1969). In Frontiers in Neuroendocrinology (ed. W. F. Ganong and L. Martini), Oxford University Press, London, pp. 307–42Google Scholar
  50. Handwerker, H. O., Iggo, A. and Zimmermann, M. (1975). Pain, 1, 147–65PubMedCrossRefGoogle Scholar
  51. Harris, G. W. (1955). Neural Control of Pituitary Gland. Edward Arnold, LondonGoogle Scholar
  52. Harris, M. C. and Sanghera, M. (1974). Brain Res., 81, 401–11PubMedCrossRefGoogle Scholar
  53. Hayward, J. N. and Jennings, D. P. (1973) J.Physiol., Lond., 232, 545–72PubMedPubMedCentralCrossRefGoogle Scholar
  54. Henry, J. L., Krnjević, K. and Morris, M. E. (1974). Fedn Proc., 33, 548Google Scholar
  55. Henry, J. L. (1975). Neurosci.Abstr., 1, 390Google Scholar
  56. Henry, J. L. (1976). Brain Res., 114, 439–51PubMedCrossRefGoogle Scholar
  57. Henry, J. L. (1977). In Substance P (ed. U. S. von Euler and B. Pernow), Raven Press, New York (in press)Google Scholar
  58. Henry, J. L. and Ben-Ari, Y. (1976). Brain Res., 117, 540–44PubMedCrossRefGoogle Scholar
  59. Henry, J. L., Krnjevib, K. and Morris, M. E. (1975). Can.J.Physiol.Pharmac., 53, 423–32CrossRefGoogle Scholar
  60. Highstein, S. M. and Bennet, M. V. L. (1975). Brain Res., 98, 229–42PubMedCrossRefGoogle Scholar
  61. Hökfelt, T., Efendić, S., Hellerström, C., Johansson, O., Luft, R. and Arimura, A. (1975). Acta Endocr., 80, suppl. 200, 1–40Google Scholar
  62. Hökfelt, T., Elde, R., Johansson, O., Luft, R., Nilsson, G. and Arimura, A. (1976). Neuroscience, 1, 131–36PubMedCrossRefGoogle Scholar
  63. Hökfelt, T., Fuxe, K., Johansson, O., Jeffcoate, S. L. and White, N. (1975a). Neurosci.Lett., 1, 133–139PubMedCrossRefGoogle Scholar
  64. Hökfelt, T., Fuxe, K., Johansson, O., Jeffcoate, S. and White, N. (1975b). Eur.J.Pharmac., 34, 389–392CrossRefGoogle Scholar
  65. Jackson, I. M. D. and Reichlin, S. (1974). Endocrinology, 95, 854–62PubMedCrossRefGoogle Scholar
  66. Kandel, E. R. (1964). J. gen. Physiol., 47, 691–717PubMedPubMedCentralCrossRefGoogle Scholar
  67. Kawakami, M. and Sakuma, Y. (1974). Endocrinology, 15, 290–307Google Scholar
  68. Kawakami, M. and Sakuma, Y. (1976). Brain Res., 101, 79–94PubMedCrossRefGoogle Scholar
  69. Kelly, J. S. (1975). In Handbook of Psychopharmacology, Vol. II (ed. L. L. Iversen, S. D. Iversen and S. H. Snyder), Plenum Press, New York, pp. 29–67Google Scholar
  70. Kelly, J. S. and Renaud, L. P. (1973). Br. J. Pharmac., 48, 369–386CrossRefGoogle Scholar
  71. Kelly, J. S., Simmonds, M. A. and Straughan, D. W. (1975). In Methods in Brain Research (ed. P. B. Bradley), Wiley, New York, pp. 333–77Google Scholar
  72. Kelly, M. J. and Moss, R. M. (1976). Neuropharmacology, 15, 325–28PubMedCrossRefGoogle Scholar
  73. Knuttsson, E., Lindblom, U. and Martensson, A. (1973). Brain, 96, 29–46CrossRefGoogle Scholar
  74. Koizumi, K. and Yamashita, H. (1972). J.Physiol., Lond., 221, 683–705PubMedPubMedCentralCrossRefGoogle Scholar
  75. Konishi, S. and Otsuka, M. (1974a). Brain Res., 65, 397–410PubMedCrossRefGoogle Scholar
  76. Konishi, S. and Otsuka, M. (1974b). Nature, 252, 734–35PubMedCrossRefGoogle Scholar
  77. Krnjević, K. (1971). In Methods in Neurochemistry (ed. R. Fried), Marcel Dekker, New York, pp. 129–72Google Scholar
  78. Krnjević, K. (1974). Physiol.Rev., 54, 418–540Google Scholar
  79. Krnjević, K. (1977). In Substance P (ed. U. S. von Euler and B. Pernow), Raven Press, New York, pp. 217–30Google Scholar
  80. Krnjević, K. and Morris, M. E. (1974). Can.J.Physiol.Pharmac., 52, 736–44CrossRefGoogle Scholar
  81. Krnjević, K. and Morris, M. E. (1976). J.PhysioL, Lond., 257, 791–815PubMedPubMedCentralCrossRefGoogle Scholar
  82. Krnjević, K., Pumain, R. and Renaud, L. (1971). J.PhysioL, Lond., 215, 247–268PubMedPubMedCentralCrossRefGoogle Scholar
  83. Lote, C. J., Gent, J. P., Wolstencroft, J. H. and Szelke, M. (1976). Nature, 264, 188–89PubMedCrossRefGoogle Scholar
  84. Makara, G. B., Harris, M. C. and Spyer, K. M. (1972). Brain Res., 40, 283–90PubMedCrossRefGoogle Scholar
  85. McLean, A. S., Sirett, N. E., Bray, J. J. and Hubbard, J. I. (1975). Proc. Univ. Otago med.Sch., 53, 19–20Google Scholar
  86. McLellan, D. L. (1973). J.Neurol.Neurosurg.Psychiat., 36, 555–60PubMedPubMedCentralCrossRefGoogle Scholar
  87. Miletić, V., Kovacs, M. S. and Randić, M. (1977). Fedn Proc., 36, 1014, Abstr., 3915Google Scholar
  88. Minnich, J. L., Ganten, D., Barbeau, A. and Genest, J. (1972). In Hypertension (ed. J. Genest and K. Koin), Springer-Verlag, Berlin, pp. 432–35Google Scholar
  89. Moss, R. L. (1976). In Frontiers in Neuroendocrinology, Vol. 4 (ed. L. Martini and W. F. Ganong), Raven Press, New York, pp. 95–128Google Scholar
  90. Moss, R. L. (1977). Fedn Proc., 36, 1978–83Google Scholar
  91. Moss, R. L., Dudley, C. A. and Kelly, M. J. (1977). Neuropharmacology, (in press).Google Scholar
  92. Moss, R. L., Dyball, R. E. J. and Cross, B. A. (1972). Expl Neurol., 14, 95–102CrossRefGoogle Scholar
  93. Moss, R. L., Kelly, M. and Riskind, P. (1975). Brain Res., 89, 265–77PubMedCrossRefGoogle Scholar
  94. Moss, R. L. and McCann, S. M. (1973). Science, 181, 177–79PubMedCrossRefGoogle Scholar
  95. Myers, R. D. (1974). Handbook of Drug and Chemical Stimulation of the Brain. Van Nostrand Reinhold Co., New YorkGoogle Scholar
  96. Negoro, H., Visessuwan, Sand Holland, R. C. (1973). Brain Res., 57, 479–83PubMedCrossRefGoogle Scholar
  97. Nicoll, R. A. (1976). In Neurotransmitters, Hormones and Receptors: Novel approaches (ed. J. A. Ferrendeffi, B. S. McEwan and S. H. Snyder), Society for Neuroscience, Bethesda, Md. pp. 99–122Google Scholar
  98. Nicoll, R. A. (1977). Nature, 265, 242–43PubMedCrossRefGoogle Scholar
  99. Nicoll, R. A. and Barker, J. L. (1971a). Nature new Biol., 233, 172–74PubMedCrossRefGoogle Scholar
  100. Nicoll, R. A. and Barker, J. L. (1971b). Brain Res., 35, 501–11PubMedCrossRefGoogle Scholar
  101. Nicoll, R. A., Siggins, G. R., Ling, N., Bloom, F. E. and Guillemin, R. (1977). Proc. natn Acad. Sci., U.S.A., 74, 2584–89CrossRefGoogle Scholar
  102. Osborne, M. J., Pooters, N., Angles d’Auriac, G., Epstein, A. N., Worcel, M. and Meyer, P. (1971). Pflügers Arch. ges. Physiol., 326, 101–114CrossRefGoogle Scholar
  103. Otsuka, M. and Konishi, S. (1974).Google Scholar
  104. Otsuka, M. and Konishi, S. (1975). Cold Spring Harb. Symp. quant.Biol., 40, 135–43CrossRefGoogle Scholar
  105. Otsuka, M. and Konishi, S. (1976). Nature, 264, 83–84PubMedCrossRefGoogle Scholar
  106. Otsuka, M., Konishi, S. and Takahashi, T. (1972a). Proc.Japan Acad., 48, 747Google Scholar
  107. Otsuka, M., Konishi, S. and Takahashi, T. (1972b). Proc.Japan.Acad., 48, 342–46Google Scholar
  108. Otsuka, M. and Konishi, S. (1974). Nature, 252, 733PubMedCrossRefGoogle Scholar
  109. Pfaff, D. W. (1973). Science, 182, 1148–49PubMedCrossRefGoogle Scholar
  110. Phillips, M. I. and Felix, D. (1975). Neurosci. Abstr., 1, 469Google Scholar
  111. Phillips, M. I. and Felix, D. (1976). Brain Res., 1, 531–40CrossRefGoogle Scholar
  112. Phillis, J. W. (1976). Experientia, 32, 593–94PubMedCrossRefGoogle Scholar
  113. Phillis, J. W. (1977). In Approaches to the Cell biology of Neurons (ed. W. M. Cowan and J. A. Ferrendelli). Society for Neuroscience, Bethesda, Md. pp. 241–264Google Scholar
  114. Phillis, J. W. and Limacher, J. J. (1974a). Brain Res., 69, 158–63PubMedCrossRefGoogle Scholar
  115. Phillis, J. W. and Limacher, J. J. (1974b). Expl Neurol., 43, 414–23CrossRefGoogle Scholar
  116. Pickel, V. M., Reis, D. J. and Leeman, S. E. (1977). Brain Res., 122, 534–40PubMedCrossRefGoogle Scholar
  117. Pierau, F. K. and Zimmermann, P. (1973). Brain Res., 54, 376–80PubMedCrossRefGoogle Scholar
  118. Poth, M. M., Heath, R. G. and Ward, M. (1975). J.Neurochem., 25, 83–85PubMedCrossRefGoogle Scholar
  119. Prange, A. J. Jr., Nemeroff, C. B., Lipton, M. S., Breese, G. R. and Wilson, I. C. (1977). In Handbook of Psychopharmacology, Section II (ed. L. L. Iversen, S. D. Iversen and S. H. Snyder), Plenum Press, New York, (in press)Google Scholar
  120. Randié, M. and Miletid, V. (1977). In Iontophoresis and Transmitter Mechanisms in the Mammalian Central Nervous System (ed. R. Ryall and J. S. Kelly), Elsevier, Amsterdam, (in press)Google Scholar
  121. Reid, I. A. and Ramsay, D. J. (1975). Endocrinology, 97, 536–42PubMedCrossRefGoogle Scholar
  122. Renaud, L. P. (1975). Neurosci. Abstr., 1, 441Google Scholar
  123. Renaud, L. P. (1976a). J. PhysioL, Lond., 254, 20P - 21 PPubMedGoogle Scholar
  124. Renaud, L. P. (1976b). Brain Res., 105, 59–72PubMedCrossRefGoogle Scholar
  125. Renaud, L. P. (1976c). J.Physiol., Lond., 260, 237–52PubMedPubMedCentralCrossRefGoogle Scholar
  126. Renaud, L. P. (1977a). J.Physiol, Lond., 264, 541–64PubMedPubMedCentralCrossRefGoogle Scholar
  127. Renaud, L. P. (1977b). In Approaches to the Cell Biology of Neurons (ed. W. M. Cowan and J. A. Ferrendelli), Society for Neuroscience, Bethesda, Md. pp. 265–90Google Scholar
  128. Renaud, L. P., Blume, H. W. and Pittman, Q. J. (1978). In Frontiers in Neuroendocrinology, Vol. 5 (ed. W. F. Ganong and L. Martini), Raven Press, New York, (in press)Google Scholar
  129. Renaud, L. P. and Martin, J. B. (1975a). In Anatomical Neuroendocrinology (ed. W. E. Stumpf and L. E. Grant), Karger, Basel, pp. 354–56Google Scholar
  130. Renaud, L. P. and Martin, J. B. (1975b). Brain Res., 86, 150–54PubMedCrossRefGoogle Scholar
  131. Renaud, L. P., Martin, J. B. and Brazeau, P. (1975). Nature, 255, suppl. 1, 233–35PubMedCrossRefGoogle Scholar
  132. Renaud, L. P., Martin, J. B. and Brazeau, P. (1976). Pharmac.Biochem.Behay., 5, 171–78CrossRefGoogle Scholar
  133. Roth, M., Weitzman, A. F. and Piquilloud, Y. (1969). Experientia, 25, 1247PubMedCrossRefGoogle Scholar
  134. Saito, K., Konishi, S. and Otsuka, M. (1975). Brain Res., 97, 177–80PubMedCrossRefGoogle Scholar
  135. Sakai, K. K., Marks, B. H., George, J. M. and Koestner, A. (1974a). J. Pharmac. exp. Ther., 190, 482–91Google Scholar
  136. Sakai, K. K., Marks, B. H., George, J. and Koestner, A. (1974b). Life Scl., 14, 1337–44CrossRefGoogle Scholar
  137. Sawaki, Y. and Yagi, K. (1973). J.Physiol., Lond., 230, 75–85PubMedPubMedCentralCrossRefGoogle Scholar
  138. Sawaki, Y. and Yagi, K. (1976). J.Physiol., Lond., 260, 447–460PubMedPubMedCentralCrossRefGoogle Scholar
  139. Schulman, J. A. and Weight, F. F. (1976). Science, 194, 1437–39PubMedCrossRefGoogle Scholar
  140. Severs, W. B. and Daniels-Severs, A. E. (1973). Pharmac.Rev., 25, 415–449Google Scholar
  141. Severs, W. B. and Summy-Long, J. (1975). Life Sci., 17, 1513–26PubMedCrossRefGoogle Scholar
  142. Simpson, J. B. and Routtenberg, A. (1973). Science, 181, 1172–75PubMedCrossRefGoogle Scholar
  143. Spira, M. E., Model, P. G. and Bennet, M. V. L. (1970). J.Cell BioL, 47, 199–200AGoogle Scholar
  144. Steinacker, A. and Highstein, S. M. (1976). Brain Res., 114, 128–133PubMedCrossRefGoogle Scholar
  145. Steiner, F. A. (1975). In Anatomical Neuroendocrinology (ed. W. E. Stumpf and L. E. Grant), Karger, Basel, pp. 270–275Google Scholar
  146. Szentagothai, J., Flerkć, B., Mess, B. and Halksz, B. (1968). Hypothalamic Control of the Anterior Pituitary. Akademiai Kiado, BudapestGoogle Scholar
  147. Takahashi, T., Konishi, S., Powell, D., Leeman, S. E. and Otsuka, M. (1974). Brain Res., 73, 59–69PubMedCrossRefGoogle Scholar
  148. Takahashi, T. and Otsuka, M. (1975). Brain Res., 87, 1–11PubMedCrossRefGoogle Scholar
  149. Tan, A. T., Tsang, D., Renaud, L. P. and Martin, J. B. (1977). Brain Res., 123, 193–96PubMedCrossRefGoogle Scholar
  150. Vale, W., Ling, N., Rivier, J., Villarreal, J., Rivier, C., Douglas, C. and Brown, M. (1976). Metabolism, 25, suppl. 1, 1491–94PubMedCrossRefGoogle Scholar
  151. von Euler, U. S. and Gaddum, J. H. (1931). J.Physiol., Lond., 72, 74–87CrossRefGoogle Scholar
  152. Walker, R. J., Kemp, J. A., Yajima, H., Kitagawa, K. and Woodruff, G. N. (1976). Experientia, 32, 214–15PubMedCrossRefGoogle Scholar
  153. Wayner, M. J., Ono, T. and Nolley, D. (1973). Pharmac.Biochem.Behay., 1, 679–91CrossRefGoogle Scholar
  154. Werman, R. (1966). Comp.Biochem.Physiol., 18, 745–66PubMedCrossRefGoogle Scholar
  155. Weight, F. F. (1974). In Neurosciences Third Study Program (ed. S. O. Schmidt and F. G. Worden), MIT Press, Boston, pp. 929–41Google Scholar
  156. Weight, F. F. and Padjen, A. (1973). Brain Res., 55, 219–24PubMedCrossRefGoogle Scholar
  157. Wilbur, J. F., Montoya, E., Plotnikoff, N., White, W. F., Genrich, R., Renaud, L. and Martin, J. B. (1976). Recent Progress Horm. Res., 32, 117–53Google Scholar
  158. Yagi, K. and Sawaki, Y. (1975). Brain Res., 84, 155–59PubMedCrossRefGoogle Scholar
  159. Yagi, K. and Sawaki, Y. (1977). Brain Res., 120, 342–346PubMedCrossRefGoogle Scholar
  160. Yang, H. Y. and Neff, N. H. (1972). J.Neurochem., 19, 2443–50PubMedCrossRefGoogle Scholar
  161. Yarbrough, G. G. (1976). Nature, 263, 523–24PubMedCrossRefGoogle Scholar

Copyright information

© Institute of Biology Endowment Trust Fund 1978

Authors and Affiliations

  • Leo P. Renaud
    • 1
  • Ante Padjen
    • 1
  1. 1.Division of Neurology, Montreal General Hospital and Department of Pharmacology and Experimental TherapeuticsMcGill UniversityMontrealCanada

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