Immunohistochemical localization of peptides in the nervous system

  • Robert Elde
  • Tomas Hökfelt
  • Olle Johansson
  • Åke Ljungdahl
  • Göran Nilsson
  • S. L. Jeffcoate
Part of the Biological Council book series


Peptides from the nervous system that act as extracellular messengers have been studied for many years by neuroendocrinologists. The activity of these hypothalamic hormones, such as vasopressin, oxytocin and the releasing factors, was thought to be directed only to target tissues outside of the nervous system. However, in recent years, it has become apparent that some of these neuroendocrine peptides as well as other peptides, are widely distributed in the nervous system and are capable of influencing neuronal activity. Therefore, certain peptides may act as interneuronal messengers, a possibility now being tested in many neurobiological laboratories. In this paper we present and discuss some findings from our laboratory on the regional distribution of neuropeptides as revealed by an immunohistochemical approach. Some of these findings have been reviewed (Hökfelt et al., 1977b, d; Elde and Hökfelt, 1978) from somewhat different perspectives.


Cell Body Thyrotropin Release Hormone Median Eminence Suprachiasmatic Nucleus Luteinising Hormone releaSing Hormone 
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Copyright information

© Institute of Biology Endowment Trust Fund 1978

Authors and Affiliations

  • Robert Elde
    • 1
  • Tomas Hökfelt
    • 1
  • Olle Johansson
    • 1
  • Åke Ljungdahl
    • 1
  • Göran Nilsson
    • 1
  • S. L. Jeffcoate
    • 2
  1. 1.Departments of Histology and PharmacologyKarolinska InstituteStockholmSweden
  2. 2.National Institute for Biological Standards and ControlHolly Hill, Hampstead, LondonUK

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