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Immunohistochemical localization of peptides in the nervous system

  • Chapter
Centrally Acting Peptides

Part of the book series: Biological Council

Abstract

Peptides from the nervous system that act as extracellular messengers have been studied for many years by neuroendocrinologists. The activity of these hypothalamic hormones, such as vasopressin, oxytocin and the releasing factors, was thought to be directed only to target tissues outside of the nervous system. However, in recent years, it has become apparent that some of these neuroendocrine peptides as well as other peptides, are widely distributed in the nervous system and are capable of influencing neuronal activity. Therefore, certain peptides may act as interneuronal messengers, a possibility now being tested in many neurobiological laboratories. In this paper we present and discuss some findings from our laboratory on the regional distribution of neuropeptides as revealed by an immunohistochemical approach. Some of these findings have been reviewed (Hökfelt et al., 1977b, d; Elde and Hökfelt, 1978) from somewhat different perspectives.

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Author information

Author notes

  1. Robert Elde

    Present address: Department of Anatomy, University of Minnesota, Minneapolis, Minnesota, 55455, USA

Authors and Affiliations

  1. Departments of Histology and Pharmacology, Karolinska Institute, Stockholm, Sweden

    Robert Elde, Tomas Hökfelt, Olle Johansson, Åke Ljungdahl & Göran Nilsson

  2. National Institute for Biological Standards and Control, Holly Hill, Hampstead, London, UK

    S. L. Jeffcoate

Authors
  1. Robert Elde
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  2. Tomas Hökfelt
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  3. Olle Johansson
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  4. Åke Ljungdahl
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  5. Göran Nilsson
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  6. S. L. Jeffcoate
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Imperial College of Science and Technology, University of London, UK

    J. Hughes Ph.D.

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© 1978 Institute of Biology Endowment Trust Fund

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Elde, R., Hökfelt, T., Johansson, O., Ljungdahl, Å., Nilsson, G., Jeffcoate, S.L. (1978). Immunohistochemical localization of peptides in the nervous system. In: Hughes, J. (eds) Centrally Acting Peptides. Biological Council. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03668-4_2

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