Advertisement

Behavioural effects of neuropeptides related to ß-LPH

  • D. de Wied
Part of the Biological Council book series

Abstract

The lipotropic hormone β-lipotropin (β-LPH) was first isolated in 1964 from sheep pituitaries (Li, 1964). It is located in discrete cells of the anterior and intermediate lobes of the pituitary (Moon et al., 1973). β-LPH consists of 90 or 91 amino acids and the sequence does not vary much among the species (Li and Chung, 1976). The residues 41–58 resemble those found in the melanocyte stimulating hormone β-MSH (table 16.1). Thus, β-LPH may be a pro-hormone for this polypeptide. Other β-LPH fragments were recently found in pituitary material and each of the various peptides generated from β-LPH seems to be formed by cleavage of the lipotropin chain at the carboxyl side of paired basic residues (Bradbury et al., 1976 a ). Residues 47–53 are identical to residues 4–10 that are found in adrenocorticotropic hormone (ACTH) and in α- and β-MSH. This sequence has not been found in pituitary extracts but this or a related peptide could well be generated from β-LPH, ACTH, α- or β-MSH.

Keywords

Avoidance Behaviour Related Peptide Opiate Receptor ACTH Fragment Melanocyte Stimulate Hormone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Akil, H., Mayer, D. J. and Liebeskind, J. C. (1972). C.r. hebd. Séanc. Acad. Sci., Paris, 274, 3603–05Google Scholar
  2. Applezweig, M. H. and Baudry, F. D. (1955). Psychol. Rep., 1, 417–20CrossRefGoogle Scholar
  3. Baldwin, D. M., Haun, Ch. K. and Sawyer, Ch. H. (1974). Brain Res., 80, 291–301CrossRefGoogle Scholar
  4. Bloom, F., Segal, D., Ling, N. and Guillemin, R. (1976). Science, 194, 630–32CrossRefGoogle Scholar
  5. Bohus, B. and de Wied, D. (1966). Science, 153, 318–20CrossRefGoogle Scholar
  6. Bohus, B., Gispen, W. H. and de Wied, D. (1973). Neuroendocrinology, 11, 137–43CrossRefGoogle Scholar
  7. Bohus, B., Hendrickx, H. H. L., van Kolfschoten, A. A. and Krediet, T. G. (1975). In Sexual Behavior: Pharmacology and Biochemistry (ed. M. Sandler and G. L. Gessa ), Raven Press, New York, pp. 269–75Google Scholar
  8. Bradbury, A. F., Smyth, D. G. and Snell, C. R. (1976a), Biochem. biophys. Res. Commun., 69, 950–56CrossRefGoogle Scholar
  9. Bradbury, A. F., Smyth, D. G., Snell, C. R., Birdsall, N. J. M. and Hulme, E. C. (1976b). Nature, 260, 793–95CrossRefGoogle Scholar
  10. Brown, G. M., Uhlir, I. V., Seggie, J., Schally, A. V. and Kastin, A. J. (1974). Endocrinology, 94, 583–87CrossRefGoogle Scholar
  11. Coy, D. H., Kastin, A. J., Schally, A. V., Morin, O., Caron, N. G., Labrie, F., Walker, J. M., Fertel, R., Berntson, G. G. and Sandman, C. A. (1976). Biochem. biophys. Res. Commun., 73, 632–38.CrossRefGoogle Scholar
  12. Dyster-Aas, H. K. and Krakau, C. E. T. (1965). Acta Endocr. (Kbh.), 48, 409–192Google Scholar
  13. E1-Sobky, A., Dostrovsky, J. O. and Wall, P. D. (1976). Nature, 263, 783–84CrossRefGoogle Scholar
  14. Ferrari, W., Gessa, G. L. and Vargiu, L. (1963). Ann. N.Y. Acad. Sei., 104, 330–45CrossRefGoogle Scholar
  15. Flexner, J. B. and Flexner, L. B. (1971). Proc. natn. Acad. Sci. U.S.A., 68, 2519–21CrossRefGoogle Scholar
  16. Flood, J. F., Jarvik, M. E., Bennett, E. L. and Orme, A. E. (1976). Pharmac. Biochem. Behay., 5, 41–51CrossRefGoogle Scholar
  17. Gaillard, A. W. K. and Sanders, A. F. (1975). Psychopharmacologia, 42, 201–08CrossRefGoogle Scholar
  18. Garrud, P., Gray, J. A. and de Wied, D. (1974). Physiol. Behay., 12, 109–19CrossRefGoogle Scholar
  19. Gessa, G. L., Pisano, M., Vargiu, L., Crabai, F. and Ferrari, W. (1967). Rev. Can. Biol., 26, 229–36Google Scholar
  20. Gispen, W. H. and Wiegant, V. M. (1976). Neurosci. Lett., 2, 159–64CrossRefGoogle Scholar
  21. Gispen, W. H., Wiegant, V. M., Greven, H. M. and de Wied, D. (1975). Life Sci., 17, 645–52CrossRefGoogle Scholar
  22. Gispen, W. H., Buitelaar, J., Wiegant, V. M., Terenius, L. and de Wied, D. (1976a). Eur. J. Pharmac., 39, 393–97CrossRefGoogle Scholar
  23. Gispen, W. H., Wiegant, V. M., Bradbury, A. F., Hulme, E. C., Smyth, D. G., Snell, C. R. and de Wied, D. (1976b). Nature, 264, 794–95CrossRefGoogle Scholar
  24. Gispen, W. H., van Ree, J. M. and de Wied, D. (1977). Int. Rev. Neurobiol., 20, 209–50CrossRefGoogle Scholar
  25. Gold, P. E. and Van Buskirk, R. (1976). Behay. Biol., 16, 387–400CrossRefGoogle Scholar
  26. Goldstein, A. and Lowery, P. J. (1975) Life Sci., 17, 927–32CrossRefGoogle Scholar
  27. Goldstein, A., Pryor, G. T., Otis, L. S. and Larsen, F. (1976). Life Sci., 18, 599–604CrossRefGoogle Scholar
  28. Gray, J. A. (1971). Nature, 229, 52–54CrossRefGoogle Scholar
  29. Greven, H. M. and de Wied, D. (1973). In Drug Effects on Neuroendocrine Regulation (ed. E. Zimmermann, W. H. Gispen, B. H. Marks and D. de Wied), Progress in Brain Research Vol. 39. Elsevier, Amsterdam, pp. 429–42CrossRefGoogle Scholar
  30. Greven, H. M. and de Wied, D. (1977). In Melanocyte Stimulating Hormone: Control, Chemistry and Effects (ed. F. J. H. Tilders, D. F. Swaab and Tj. B. van Wimersma Greidanus), Frontiers of Hormone Research Vol. 4. Karger, Basel, (in press)Google Scholar
  31. Guth, S., Levine, S. and Seward, J. P. (1971). Physiol. Behay., 7, 195–200CrossRefGoogle Scholar
  32. Holtzman, S. G. (1974). J. Pharmac. exp. Ther., 189, 51–60Google Scholar
  33. Isaacson, R. L., Dunn, A. J., Rees, H. D. and Waldock, B. (1976). Physiol. Psychol., 4, 159–62CrossRefGoogle Scholar
  34. Izumi, K., Donaldson, J. and Barbeau, A. (1973). Life Sci., 12, 203–10CrossRefGoogle Scholar
  35. Jacquet, Y. F. and Marks, N. (1976). Science, 194, 632–34CrossRefGoogle Scholar
  36. Kastin, A. J., Miller, L. H., Nockton, R., Sandman, C. A., Schally, A. V. and Stratton, L. O. (1973a). In Drug Effects on Neuroendocrine Regulation. (ed. E. Zimmermann, W. H. Gispen, B. H. Marks and D. de Wied), Progress in Brain Research Vol. 39, Elsevier, Amsterdam, pp. 461–70CrossRefGoogle Scholar
  37. Kastin, A. J., Miller, M. C., Ferrell, L. and Schally, A. V. (1973b). Physiol. Behay., 10, 399–401CrossRefGoogle Scholar
  38. Kastin, A. J., Sandman, C. A., Stratton, L. O., Schally, A. V. and Miller, L. H. (1975). In Hormones, Homeostasis and the Brain. (ed. H. Gispen, Tj. B. van Wimersma Greidanus, B. Bohus and D. de Wied), Progress in Brain Research Vol. 42, Elsevier, Amsterdam, pp. 143–50Google Scholar
  39. Kastin, A. J., Scollan, E. L., King, M. G., Schally, A. V. and Coy, D. H. (1976). Pharmac. Biochem. Behay., 5, 691–95CrossRefGoogle Scholar
  40. Kuhar, M. J., Pert, C. B. and Snyder, S. H. (1973). Nature, 245, 447–50CrossRefGoogle Scholar
  41. Lal, H., Miksic, S. and Smith, N. (1976). Life Sci., 18, 971–76CrossRefGoogle Scholar
  42. Lande, S., de Wied, D. and Witter, A. (1973). In Drug Effects on Neuroendocrine Regulation (ed. E. Zimmermann, W. H. Gispen, B. H. Marks and D. de Wied), Progress in Brain Research Vol. 39, Elsevier, Amsterdam, pp. 421–27CrossRefGoogle Scholar
  43. Leonard, B. E. (1969). Int. J. Neuropharmac., 8, 427–35CrossRefGoogle Scholar
  44. Levine, S. and Jones, L. E. (1965). J. comp. physiol. Psychol., 59, 357–60CrossRefGoogle Scholar
  45. Li, C. H. (1964). Nature, 201, 924CrossRefGoogle Scholar
  46. Li, C. H. and Chung, D. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 1145–48CrossRefGoogle Scholar
  47. Ling, N. and Guillemin, R. (1976). Proc. natn. Acad. Sci. U.S.A., 73, 3308–10CrossRefGoogle Scholar
  48. Lissak, K. and Bohus, B. (1972). Int. J. Psychobiol., 2, 103–15Google Scholar
  49. Meyerson, B. J. and Terenius, L. (1977). Eur. J. Pharmac., 42, 191–92CrossRefGoogle Scholar
  50. Moon, H. D., Li, C. H. and Jenning, B. M. (1973). Anat. Rec., 175, 529–38CrossRefGoogle Scholar
  51. Moyer, K. E. (1966). J. genet. Psychol., 108, 297–302CrossRefGoogle Scholar
  52. Nockton, R., Kastin, A. J., Elder, S. T. and Schally, A. V. (1972). Horm. Behay., 3, 339–44CrossRefGoogle Scholar
  53. Oliveras, J. L., Hosobuchi, Y., Redjemi, R., Guilbaud, G. and Besson, J. M. (1977). Brain Res., 120, 221–29CrossRefGoogle Scholar
  54. Pedigo, N. W., Dewey, W. L. and Harris, L. S. (1975). J. Pharmac. exp. Ther., 193, 845–52Google Scholar
  55. Pomeranz, B. and Chiu, D. (1976). Life Sci., 19, 1757–62CrossRefGoogle Scholar
  56. Rees, H. D., Dunn, A. J. and Iuvone, P. M. (1976). Life Sci., 18, 1333–40CrossRefGoogle Scholar
  57. Rigter, H. and Popping, A. (1976). Psychopharmacologia, 46, 255–61CrossRefGoogle Scholar
  58. Rigter, H. and van Riezen, H. (1975). Physiol. Behay., 14, 563–66CrossRefGoogle Scholar
  59. Rigter, H., van Riezen, H. and de Wied, D. (1974). Physiol. Behay., 13, 381–88CrossRefGoogle Scholar
  60. Sakamoto, A. (1966). Nature, 211, 1370–71CrossRefGoogle Scholar
  61. Sandman, C. A., Kastin, A. J. and Schally, A. V. (1969). Experientia, 25, 1001–02CrossRefGoogle Scholar
  62. Terenius, L. (1975). J. Pharm. Pharmac., 27, 450–52CrossRefGoogle Scholar
  63. Terenius, L. (1976). Eur. J. Pharmac., 38, 211–13CrossRefGoogle Scholar
  64. Terenius, L., Gispen, W. H. and de Wied, D. (1975). Eur. J. Pharmac., 33, 395–99CrossRefGoogle Scholar
  65. Urban, I. and de Wied, D. (1976). Expl. Brain Res., 24, 325–44CrossRefGoogle Scholar
  66. Verhoef, J., Witter, A. and de Wied, D. (1977). Brain Res., 131, 117–28CrossRefGoogle Scholar
  67. Weiss, J. M., McEwen, B. S., Silva, M. and Kalkut, M. (1970). Am. J. Physiol., 218, 864–68Google Scholar
  68. Weijnen, J. A. W. M. and Slangen, J. L. (1970). In Pituitary, Adrenal and the Brain (ed. D. de Wied and J. A. W. M. Weijnen) Progress in Brain Research Vol. 32, Eslevier, Amsterdam, pp. 221–35CrossRefGoogle Scholar
  69. de Wied, D. (1964). Am. J. Physiol., 207, 255–59Google Scholar
  70. de Wied, D. (1966). Proc. Soc. Exp. Biol., 122, 28–32CrossRefGoogle Scholar
  71. de Wied D. (1969a). In Frontiers in Neuroendocrinology 1969 (ed. W. F. Ganong and L. Martini) University Press, London/New York, pp. 97–140Google Scholar
  72. de Wied, D. (1969b). Proc. 3rd Int. Congr. Endocrinology, Mexico, June/July 1968. Excerpta Medica International Congress Series No. 184, Excerpta Medica, Amsterdam, pp. 310–16Google Scholar
  73. de Wied, D. (1974). In The Neurosciences, Third Study Program (ed. F. O. Schmitt and F. G. Worden ), MIT Press, Cambridge, Massachusetts, pp. 653–66Google Scholar
  74. de Wied, D., Bohus, B., van Ree, J. M. and Urban, I. (1977). Submitted for publicationGoogle Scholar
  75. Wiegant, V. M. and Gispen, W. H. (1977). Behay. Biol., 19, 554–58, abstr. no. 6241CrossRefGoogle Scholar
  76. Winter, C. A. and Flataker, L. (1951). J. Pharmac. exp. Ther., 101, 93Google Scholar
  77. Zimmermann, E. and Krivoy, W. A. (1973). In Drug Effects on Neuroendocrine Regulation (ed. E. Zimmermann, W. H. Gispen, B. H. Marks and D. de Wied) Progress in Brain Research Vol. 39, Elsevier, Amsterdam, pp. 383–94CrossRefGoogle Scholar

Copyright information

© Institute of Biology Endowment Trust Fund 1978

Authors and Affiliations

  • D. de Wied
    • 1
  1. 1.Rudolf Magnus Institute for Pharmacology Medical FacultyUniversity of UtrechtUtrechtThe Netherlands

Personalised recommendations