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Biogenesis and metabolism of opiate active peptides

  • D. G. Smyth
  • B. M. Austen
  • A. F. Bradbury
  • M. J. Geisow
  • C. R. Snell
Part of the Biological Council book series

Abstract

Physiologically active peptides, elaborated intracellularly, are biosynthesised as single molecular species. In the case of peptide hormones, the functionally significant molecule is generated from the corresponding prohormone by enzymes with high specificity and the product preserved intact within secretory granules (Kemrnler et al., 1973). Thus a characteristic biological activity is not produced by a group of naturally occurring peptides with overlapping sequences. In the field of endogenous peptides with opiate activity, however, it has seemed as if this general rule does not apply.

Keywords

Secretory Granule Aminopeptidase Inhibitor Opiate Activity Soya Bean Trypsin Inhibitor Single Molecular Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Biology Endowment Trust Fund 1978

Authors and Affiliations

  • D. G. Smyth
    • 1
  • B. M. Austen
    • 1
  • A. F. Bradbury
    • 1
  • M. J. Geisow
    • 1
  • C. R. Snell
    • 1
  1. 1.Laboratory of Peptide ChemistryNational Institute for Medical ResearchLondonUK

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