Biogenesis and metabolism of opiate active peptides
Physiologically active peptides, elaborated intracellularly, are biosynthesised as single molecular species. In the case of peptide hormones, the functionally significant molecule is generated from the corresponding prohormone by enzymes with high specificity and the product preserved intact within secretory granules (Kemrnler et al., 1973). Thus a characteristic biological activity is not produced by a group of naturally occurring peptides with overlapping sequences. In the field of endogenous peptides with opiate activity, however, it has seemed as if this general rule does not apply.
KeywordsSecretory Granule Aminopeptidase Inhibitor Opiate Activity Soya Bean Trypsin Inhibitor Single Molecular Species
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