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Current Themes in Psychiatry 1 pp 94–105Cite as

Relevance of Research in Parkinson’s Disease to Psychiatry

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Abstract

The neuropathological changes associated with Parkinson’s disease were established in the early part of the present century. The biochemical changes now known to be associated with the disease were not known until much later. The distribution of amines in the brains of animals was widely explored in the 1950s and the presence of dopamine in the brains of many animals was described by Montagu in 1957. From the time of its discovery it was suggested that dopamine might be a neurotransmitter in its own right, but it was Carlsson who, in 1959, put forward the view that dopamine has an important role in the regulation of motor function.

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References

  • Ashcroft, G. W., Dow, R. C. and Moir, A. T. B. (1968). The active transport of 5 hydroxyindol-3-ylacetic acid and 3 methoxy-4-hydroxyphenyl acetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthetised dog. J. Physiol., Lond., 199, 397–425

    Article  Google Scholar 

  • Asso, D. (1969). WAIS scores in a group of parkinson patients. Br. J. Psychiat., 115, 555–6

    Article  Google Scholar 

  • Baldessarini, R. J. (1975). The basis for amine hypotheses in affective disorders. Archs gen. Psychiat., 32, 1087–1093

    Article  Google Scholar 

  • Barolin, G. S., Bernheimer, H. and Hornykiewicz, O. (1964). Seitenverschiedenes Verhalten des Dopamins (3 hydroxytyramin) im Gehirn eines Falles von Hemiparkinsonismus. Schweiz. Arch. Neurol. Psychiat., 94, 241–248

    Google Scholar 

  • Bartholini, G., Burkard, W. P., Pletscher, A. and Bates, H. M. (1967). Increase in cerebral catecholamines caused by 3, 4-dihydroxyphenylalanine after inhibition of peripheral decarboxylase. Nature, Lond., 215, 852–853

    Article  Google Scholar 

  • Bernheimer, H., Birkmayer, W. and Hornykiewicz, O. (1963). Zur Biochemie des Parkinsonsyndroms des Menschen. Klin. Wschr., 41, 465–469

    Article  Google Scholar 

  • Bird, E. D. and Iversen, L. L. (1974). Huntington’s chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia. Brain, 97, 457–472

    Article  Google Scholar 

  • Bourne, H. R., Bunney, W. E. Jr., Colburn, R. W., Davis, J. M., Davis, J. N. Shaw, D. M. and Coppen. A. J. (1968). Noradrenaline, 5-hydroxytryptamine and 5-hydroxyindolacetic acid in hindbrains of suicidal patients. Lancet, ii, 805–808

    Google Scholar 

  • Brodie, B. B., Comer, M. S., Costa, E. and Dlabac, A. (1966). Role of brain serotonin in mechanism of central action of reserpine. J. Pharmac. exp. Ther., 152, 340–349

    Google Scholar 

  • Carlsson, A. (1959). The occurrence, distribution and physiological role of catecholamines in the nervous system. Pharmac. Rev., 11, 490–493

    Google Scholar 

  • Carlsson, A. (1968). Reporters remarks. Adv. Pharmac., 6B, 115–119

    Article  Google Scholar 

  • Carlsson, A. (1970). Biochemical implications of dopa-induced action on the central nervous system with particular reference to abnormal movements. In L-DOPA and Parkinsonism (eds Barbeau, A. and McDowell, F. H. ), pp. 205–212, F. A. Davis Co., Philadelphia

    Google Scholar 

  • Carroll, B. J. (1971). Monoamine precursors in the treatment of depression. Clin. Pharmac. Ther., 12, 743–761

    Google Scholar 

  • Celesia, G. G. and Barr, A. N. (1970). Psychosis and other psychiatric manifestations of levodopa therapy. Archs Neurol., 23, 193–200

    Article  Google Scholar 

  • Celesia, G. G. and Wanamaker, W. M. (1972). Psychiatric disturbances in Parkinson’s disease. Dis. nerv. Syst., 33, 577–583

    Google Scholar 

  • Cole, J. O. and Clyde, D. J. (1961). Extrapyramidal side-effects and clinical responses to the phenothiazines. In Extrapyramidal System and Neuroleptics (ed. Bordeleau ), Edition Psychiatriques, Montreal

    Google Scholar 

  • Coppen, A., Shaw, D. M. and Farrell, J. P. (1963). Potentiation of the antidepressant effect of a monoamine oxidase inhibitor by tryptophan. Lancet, i, 79–81

    Google Scholar 

  • Coppen, A., Metcalfe, M., Carroll, J. D. and Morris, J. G. L. (1972). Levadopa and ltryptophan therapy in Parkinsonism. Lancet, i, 654–658

    Article  Google Scholar 

  • Cotzias, G. C., Van Woert, M. H. and Schiffer, L. M. (1967). Aromatic amino-acids and modification of parkinsonism. New Engl. J. Med., 276, 374–379

    Article  Google Scholar 

  • Crow, T. J. (1972). Catecholamine containing neurones and electrical self-stimulation: I. A review of some data. Psychol. Med., 2, 414–421

    Article  Google Scholar 

  • Crow, T. J. (1973). Catecholamine containing neurones and electrical self-stimulation: II. A theoretical interpretation and some psychiatric implications. Psycho!. Med., 3, 66–73

    Article  Google Scholar 

  • Crow, T. J., Deakin, J. F. W., Johnstone, E. C. and Longden, A. (1976). Dopamine and schizophrenia. Lancet, ii, 563–566

    Google Scholar 

  • Crow, T. J. and Gillbe, C. (1972). Dopamine antagonism and antischizophrenic potency of neuroleptic drugs. Nature new Biol., 245, 27–28

    Article  Google Scholar 

  • Crow, T. J., Johnstone, E. C. and McClelland, H. A. (1976). The coincidence of schizophrenia and parkinsonism: some neuro-chemical implications. Psychol. Med., 6, 227–233

    Article  Google Scholar 

  • Damâsio, A. R., Lobo-Antunes, J. and Macedo, C. (1971). Psychiatric aspects in parkinsonism treated with L-DOPA. J. Neurol. Neurosurg. Psychiat., 34, 502–507

    Article  Google Scholar 

  • Delay, J. and Deniker, P. (1952). 38 cas de psychoses traitées par la cure prolongée et continué de 4560 RP. Le Congrès de Psychiatrie et de Neurologie de langue Française, Luxembourg, 1952, Mason, ed.

    Google Scholar 

  • Eccleston, D., Ashcroft, G. W., Moir, A. T. B., Parker-Rhodes, A., Lutz, W. and O’Mahoney, D. P. (1968). Comparison of 5-hydroxyindoles in various regions of dog brain and cerebrospinal fluid. J. Neurochem., 15, 947–957

    Article  Google Scholar 

  • Ehringer, H. and Hornykiewicz, O. (1960). Verteilung von Noradrenalin und Dopamin (3-hydroxytyramin) im Gehirn des Menschen and ihr Verhalten bei Erkrankungen des extrapyramidalen Systems. Klin. Wschr., 38, 1236–1239

    Google Scholar 

  • Garron, D. C., Klawans, H. L. and Narin, F. (1972). Intellectual functioning of persons with idiopathic parkinsonism. J. Nerv. Ment. Dis., 154, 445–452

    Article  Google Scholar 

  • Goodwin, F. K., Murphy, D. L., Brodie, H. K. H. and Bunney, W. E. (1971). Levodopa: alterations in behaviour. Clin. Pharmac. Ther., 12, 383–396

    Google Scholar 

  • Haase, H. J. (1961). Extrapyramidal modification of fine movements—`condition sine qua non’ of the fundamental therapeutic action of neuroleptic drugs. Revue Canadienne de Biologie, 20, 425–449

    Google Scholar 

  • Herman, E. and Pleasure, H. (1963). Clinical evaluation of thioridazine and chlorpromazine in chronic schizophrenics. Dis. nerv. Syst., 24, 54–59

    Google Scholar 

  • Herrington, R. N., Bruce, A., Johnstone, E. C. and Lader, M. H. (1974). Comparative trial of L-tryptophan and ECT in severe depressive illness. Lancet, ii, 731–734

    Google Scholar 

  • Hoehn, M. M. and Yahr, M. D. (1967). Parkinsonism: onset, progression and mortality. Neurology (Minneap.), 17, 427–442

    Article  Google Scholar 

  • Iversen, L. L. (1975). Dopamine receptors in the brain. Science, 188, 1084–1089

    Article  Google Scholar 

  • Jenkins, R. B. and Groh, R. H. (1970). Mental symptoms in parkinsonian patients treated with L-DOPA. Lancet, ii, 177–180

    Google Scholar 

  • Klawans, H. L., Jr. (1970a). A pharmacological analysis of Huntington’s chorea. Eur. Neurol., 4, 148–163

    Article  Google Scholar 

  • Klawans, H. L., Jr. (1970b). The pharmacology of parkinsonism. A review. Dis. nerv. Syst., 29, 805–816

    Google Scholar 

  • Loranger, A. W., Goodell, H., Lee, J. E. and McDowell, F. (1972). Levodopa treatment of parkinson’s syndrome: improved intellectual functioning. Archs gen. Psychiat., 26, 163–168

    Article  Google Scholar 

  • Marsden, C. D. and Parkes, J. D. (1973). Abnormal movement disorders. Br. J. Hosp. Med., 10, 428–450

    Google Scholar 

  • McCowan, P. K. and Cook, L. C. (1928). The mental aspect of chronic epidemic encephalitis. Lancet, i, 1316

    Article  Google Scholar 

  • Mendels, J. (1974). Brain biogenic amine depletion and mood. Archs gen. Psychiat., 30, 447–451

    Article  Google Scholar 

  • Mindham, R. H. S. (1970). Psychiatric symptoms in parkinsonism. J. Neurol. Neurosurg. Psychiat., 33, 188–191

    Article  Google Scholar 

  • Mindham, R. H. S., Marsden, C. D. and Parkes, J. D. (1976). Psychiatric symptoms during L-DOPA therapy for Parkinson’s disease and their relationship to physical disability. Psychol. Med., 6, 23–33

    Article  Google Scholar 

  • Mindham, R. H. S. and Shepherd, M. (1973). Clinical psychopharmacology. In Recent Advances in Medicine (eds Baron, Compston and Dawson ), Churchill-Livingstone, Edinburgh

    Google Scholar 

  • Mjönes, H. (1949). Paralysis Agitans: A Clinical and Genetic Study, Acta psychiat. neuro!. scand. Suppl., 54

    Google Scholar 

  • Montagu, K. A. (1957). Catechol compounds in rat tissues and in brains of different animals. Nature Lond., 180, 244–245

    Article  Google Scholar 

  • Naville, F. (1922). Etudes sur les complications et les séquelles mentales de l’encéphalite épidemique: la bradyphrenie. l’Encéphale, 17, 369–375

    Google Scholar 

  • Parkinson, J. (1817). An Essay on the Shaking Palsy, Sherwood, Neely and Jones, London

    Google Scholar 

  • Perry, T. L., Hansen, S. and Kloster, M. (1973). Huntington’s chorea: deficiency of Yamino-butyric acid in brain. New Engl. J. Med., 288, 337–342

    Article  Google Scholar 

  • Pollack, M. and Hornabrook, R. W. (1966). The prevalence, natural history and dementia of Parkinson’s disease. Brain, 89, 429–448

    Article  Google Scholar 

  • Porteous, H. B. and Ross, D. N. (1956). Mental symptoms in parkinsonism following benzhexol hydrochloride therapy. Br. med. J., 2, 138–140

    Article  Google Scholar 

  • Poskanzer, D. C. (1969). L-DOPA in Parkinson’s syndrome. Leader. New Engl. J. Med., 279, 382–383

    Article  Google Scholar 

  • Reitan, R. M. and Ball, T. J. (1971). Intellectual and cognitive functions in Parkinson’s disease. J. Cons. Clin. Psycho!., 37, 304–369

    Article  Google Scholar 

  • Sandler, M. (1972). Monoamines and mental disease. Proc. R. Soc. Med., 65, 584–585

    Google Scholar 

  • Schildkraut, J. J. (1965). The catechol amine hypothesis of affective disorders: a review of the supporting evidence. Am. J. Psychiat., 122, 509–522

    Article  Google Scholar 

  • Schildkraut, J. J. (1969). Neuropsychopharmacology and the affective disorders. New Engl. J. Med., 281, 197–201, 248–255, 302–308

    Google Scholar 

  • Schwab, R. S., Fabing, H. D. and Prichard, J. S. (1951). Psychiatric symptoms and syndromes in parkinson’s disease. Am. J. Psychiat., 107, 901–907

    Article  Google Scholar 

  • Shaw, D. M., Camps, F. E. and Eccleston, E. G. (1967). 5-Hydroxytryptamine in the hind-brain of depressive suicides. Br. J. Psychiat., 113, 1407–1411

    Google Scholar 

  • Snyder, S. H., Banerjee, S. P., Yamamura, H. I. and Greenberg, D. (1974). Drugs, neurotransmitters and schizophrenia. Science, 184, 1243–1253

    Article  Google Scholar 

  • Stephens, D. A. (1967). Psychotoxic effects of benzhexol hydrochloride (Artane). Br. J. Psychiat., 113, 213–218

    Article  Google Scholar 

  • Stimmel, G. L. (1976). Neuroleptics and the corpus striatum: clinical implications. Dis. nerv. Syst., 37, 219–224

    Google Scholar 

  • Yahr, M. D., Wolf, A., Antunes, J. L., Miyoshi, K. and Duffy, P. (1972). Autopsy findings in parkinsonism following treatment with levodopa. Neurology, 22, 56–71

    Article  Google Scholar 

  • Yaryura-Tobias, J. A., Diamond, B. and Merlis, S. (1970). The action of L-DOPA on schizophrenic patients. Curr. ther. Res., 12, 528–531

    Google Scholar 

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Authors
  1. Richard H. S. Mindham
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© 1978 Raghu N. Gaind and Barbara L. Hudson

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Mindham, R.H.S. (1978). Relevance of Research in Parkinson’s Disease to Psychiatry. In: Current Themes in Psychiatry 1. Palgrave, London. https://doi.org/10.1007/978-1-349-03642-4_9

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  • DOI: https://doi.org/10.1007/978-1-349-03642-4_9

  • Publisher Name: Palgrave, London

  • Print ISBN: 978-1-349-03644-8

  • Online ISBN: 978-1-349-03642-4

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