Removal of Bilirubin from the Blood of Jaundiced Infants
Removal of bilirubin by haemoperfusion is suggested to replace exchange transfusion of blood of jaundiced infants. Anion exchangers, coated with biocompatible polymers, were tested in vitro with human blood for bilirubin binding capacity and blood compatibility. Dowex 1 × 2 coated with poly-HEMA and an acrylic polymer crosslinked with albumin removed 50 – 75% of the initial bilirubin in 2 – 3 h. Platelet count fell by some 25%. Additional work is still required to develop a small, efficient and safe haemoperfusion system.
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