Sorbents in Therapeutic Medicine
The use of bulky equipment in renal support has been unavoidable in the past because large volumes of dialysate fluid were required. In order to make the devices smaller and portable, the amount of dialysate fluid has to be reduced and used in conjunction with a sorbent or eliminated altogether.
The use of sorbents in dialysate regeneration, their use in haemoperfusion and their potential in hepatic assist are outlined. The problems of sorbent particle release and blood trauma remain as deterrents to their widespread chronic application. Systems are proposed which may combine haemodialysis and haemoperfusion in the treatment of renal and hepatic failure. It is suggested that future development in this area will be characterised by the advent of sorbent systems exhibiting characteristics more specific to the biological needs of particular applications.
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- Agishi, T., Ohta, K., and Nosé, Y. (1975). Is hollow fibre occlusion due to maldistribution of blood? Proc. Eur. Dial. Transpl. Assoc., 12, 519.Google Scholar
- Andrade, J. D., Kunitomo, K., Van Wagenen, R., Kastigir, B., Gough, D. and Kolff, W. J. (1971). Coated adsorbents for direct blood haemoperfusion HEMA/activated carbon. Trans. Amer. Soc. Artif. Int. Organs, 17, 222.Google Scholar
- Chang, T. M. S. (1972). Artificial Cells, Thomas, Springfield, Illinois. Forstrom, R. J., Bartelt, K., Blackshear, P. L. and Wood, T. (1975). Formed element deposition onto filtering walls. Trans. Amer. Soc. Artif. Int. Organs, 21, 602.Google Scholar
- Lewin, A. J., Greenbaum, M. A., Gordon, A. and Maxwell, M. H. (1972). Current status of the clinical application of the Redy dialysate delivery system. Proc. Dial. Transpl., 2, 53.Google Scholar
- Maeda, K., Kawaguchi, S., Manji, T., Kobayashi, K., Ohta, K., Saito, A.,Shimoji, T., Yui, T. and Hori, M. (1973). Portable artificial kidney with adsorbents. Proc. Europ. Dial. Transplant. Assoc., 10, 293.Google Scholar
- Maeda, K., Kawaguchi, S., Shimizu, K., Manji, T., Kobayashi, K., Ohta, K., Saito, A., Amano, I., Yoshiyama, N., Nakogawa, S. and Koshikawa, S. (1974). Ten-litre dialysate supply system with adsorbents. Proc. Eur. Dial. Transplant. Assoc., 11, 180.Google Scholar
- Malchesky, P. S., Nokoff, R., Varves, and Nose, Y. (1976a). The charcoal capillary haemoperfusion system. Proc. Eur. Dial. Transplant. Assoc., 13 242.Google Scholar
- Malchesky, P. S., Surovy, R. M. and Nosé, Y. (1976b). The charcoal-coil: A dialysis-dialysate regeneration system. Presented at the Symposium on Sorbents in Uraemia and Hepatic Failure Downstate Medical Centre, Brooklyn, New York, November 3–4 (in press).Google Scholar
- Nosé, Y., Tajima, K. and Nakazona, M. (1972). The intracorporeal artificial kidney. Proceedings of 5th Annual Contractors Conference, p. 45.Google Scholar
- Surovy, R. M., Malchesky, P. S., Sato, H. and Nosé, Y. (1974). Charcoal-coil: A dialysis-dialysate regeneration system. Proceedings of 27th Annual Conference on Engineering in Medicine and Biology, p. 3.Google Scholar