Summary
The possibility of removing drugs directly from the intestinal tract by ingestion of sorbents is discussed. This would sequester the reservoir of the drug and, in conjunction with direct blood perfusion over sorbents, provide a two-pronged method of rapid drug removal in overdose cases.
Isotherms were measured for adsorption on activated carbon and exchange on Dowex 1 of phenobarbital, pentobarbital and secobarbital in neutral solution, acid solution, stomach fluid (pig), small intestinal fluid (pig), blood (human) and plasma (human). Severe decreases in adsorption capacity were found in the intestinal fluids. Microencapsulation in selective polymers is suggested as a method of overcoming this competitive adsorption.
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© 1977 Bioengineering Unit, University of Strathclyde
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Sparks, R.E., Gupta, D.V.S., Mason, N.S. (1977). Adsorption of Barbiturates from Buffers, Blood and Intestinal Fluids. In: Kenedi, R.M., Courtney, J.M., Gaylor, J.D.S., Gilchrist, T., Gerard, S.M. (eds) Artificial Organs. Strathclyde Bioengineering Seminars. Palgrave, London. https://doi.org/10.1007/978-1-349-03458-1_34
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DOI: https://doi.org/10.1007/978-1-349-03458-1_34
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