Summary
The Becton, Dickinson (B — D) charcoal haemodetoxification system was designed for the rapid removal of poisons from the blood of overdosed patients. Owing to the interference with the rate of solute adsorption, coupled with a lack of evidence for protection against fragmentation and platelet loss, coating of the charcoal with polymer films was not considered as a part of this system. Instead, an immobilisation process was developed which allows a maximum of surface contact between the blood and the adsorbing surface. This immobilisation gives good protection from fragmentation of the charcoal by pulsating fluid waves and fluid flows. Resistance to fluid flow is small and the loss of adsorption rate owing to the immobilisation process is minimal. Devices using this process have saved experimental animals from lethal doses of phenobarbital and have been used in man to treat drug overdose.
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© 1977 Bioengineering Unit, University of Strathclyde
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Hill, J.B., Palaia, F.L., Horres, C.R. (1977). The Design of a Charcoal Haemoperfusion System. In: Kenedi, R.M., Courtney, J.M., Gaylor, J.D.S., Gilchrist, T., Gerard, S.M. (eds) Artificial Organs. Strathclyde Bioengineering Seminars. Palgrave, London. https://doi.org/10.1007/978-1-349-03458-1_16
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DOI: https://doi.org/10.1007/978-1-349-03458-1_16
Publisher Name: Palgrave, London
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