Pharmacokinetics of pethidine and norpethidine in the rat: an application of selected ion monitoring using deuterated internal standards
During recent years there has been an increasing interest in the relationship between the pharmacokinetics and the effects of various drugs. A better understanding of such relationships is a fundamental basis for establishing a correct therapeutic dosage regimen and the adjustment of this to individual variations in, for example, drug metabolism and response (Wagner, 1975; Jellett, 1976).
KeywordsDeuterium Atom Cyanogen Bromide Peak Height Ratio Piperidine Ring Trifluoroacetic Anhydride
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