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Use of stable-isotope-labelled compounds in pharmaceutical research

  • W. J. A. VandenHeuvel

Abstract

Stable isotope labelling, especially in conjunction with mass spectrometry, plays an important role in the research leading to and the development of therapeutic agents. Internal standards for GC—MS assays, substrates for metabolism and biosynthesis studies, derivatisation reagents for metabolite structure determination, drugs with increased metabolic stability — labelling with stable isotopes has been found to afford each of the above. This presentation describes the use in pharmaceutical research of a number of deuterium-, 13C- and 15N-substituted compounds.

Keywords

Uric Acid Kinetic Isotope Effect Thiazole Ring Isotope Cluster Dioic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Contributors 1978

Authors and Affiliations

  • W. J. A. VandenHeuvel
    • 1
  1. 1.Merck Sharp and Dohme Research LaboratoriesRahwayUSA

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