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Stable isotopes in human drug metabolism studies

  • G. H. Draffan

Abstract

The resurgence of interest in the stable isotopes of hydrogen, carbon, nitrogen and oxygen in biomedical research is mainly attributable to the development of increasingly refined technology for their determination. As a result, new areas of application have opened up, and this is particularly the case in pharmaceutical research. The purpose of this paper is to consider the rôles for stable isotope labelling in the conduct of drug metabolism studies in man, and Scheme 3.1 summarises a number of these applications. At present, the largest area of activity concerns the use of labelled drugs as standards in quantitative measurement following administration of the unlabelled substance. However, administration of the stable-isotope-labelled drug can also provide valuable information and, in other cases, complements the use of a radiotracer.

Keywords

Stable Isotope Isotope Ratio Mass Spectrometer Label Drug Stable Isotope Labelling Stable Isotope Dilution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Contributors 1978

Authors and Affiliations

  • G. H. Draffan
    • 1
  1. 1.Inveresk Research InternationalEdinburghUK

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