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The role of prostaglandins in the pathogenesis of human disease: elucidation with stable isotopic methods

  • J. A. Oates
  • H. W. Seyberth
  • J. C. Frölich
  • B. J. Sweetman
  • J. T. Watson

Abstract

Prostaglandins are extremely potent biogenic compounds and as such are formed in quite small amounts in vivo. The total body production of prostaglandin E2 (PGE2), for example, is less than one µmol per day. Accordingly, the prostaglandins have provided a number of analytical challenges that have been soluble only by the use of selected ion monitoring with mass spectrometry. This is accomplished ultimately by employing stable-isotope-labelled compounds both as internal standards and as carriers.

Keywords

Mass Spectrometric Method Silicic Acid Column Bony Metastasis Urine Extract Upjohn Company 
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Copyright information

© The Contributors 1978

Authors and Affiliations

  • J. A. Oates
    • 1
  • H. W. Seyberth
    • 1
  • J. C. Frölich
    • 1
  • B. J. Sweetman
    • 1
  • J. T. Watson
    • 1
  1. 1.Departments of Medicine and PharmacologyThe Vanderbilt University School of MedicineNashvilleUSA

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