Abstract
Prostaglandins are extremely potent biogenic compounds and as such are formed in quite small amounts in vivo. The total body production of prostaglandin E2 (PGE2), for example, is less than one µmol per day. Accordingly, the prostaglandins have provided a number of analytical challenges that have been soluble only by the use of selected ion monitoring with mass spectrometry. This is accomplished ultimately by employing stable-isotope-labelled compounds both as internal standards and as carriers.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Änggård, E., Gréen, K. and Samuelsson, B. (1965). J. Biol. Chem., 240, 1932
Bartter, F. C., Gill, J. R., Frölich, J. C., Bowden, R. E., Hollifield, J. W., Radfar, N., Keiser, H. R., Oates, J. A., Seyberth, H. W. and Taylor, A. A. (1976). Trans. Assn. Am. Physicians, 89, 77
Fichman, M. P., Littenburg, G., Brooker, A. and Horton, R. (1972). Circulat. Res., 30/31 (suppl. II), 19
Frölich, J. C., Hollifield, J. W., Dormois, J. C., Frölich, B. L., Seyberth, H. W., Michelakis, A. M. and Oates, J. A. (1976a). Circulat. Res., 39, 447
Frölich, J. C., Williams, W. M., Sweetman, B. J., Smigel, M., Carr, K., Hollifield, J. W., Fleischer, S., Nies, A. S., Frisk-Holmberg, M. and Oates, J. A. (1976b). Adv. Prostaglandin and Thromboxane Research, Vol. 1 (ed. B. Samuelsson and K. Paoletti), Raven Press, New York, p. 65
Frölich, J. C. Williams, W. M., Sweetman, B. J., Smigel, M., Nies, A. S., Carr, K. Watson, J. T. and Oates, J. A. (1975). J. Clin. Invest., 55, 763
Gréen, K., Granström, E., Samuelsson, B. and Axen, U. (1973). Anal. Biochem., 54, 434
Hamberg, M. (1972). Biochem. Biophys. Res. Comm., 49, 720
Hamberg, M. and Samuelsson, B. (1971). J. Biol. Chem., 246, 6713
Klein, D. C. and Raisz, L. G. (1970). Endocrinology, 86., 1436
Larsson, C., Weber, P. and Änggård, E. (1974). Europ. J. Pharmacol., 28, 391
Rosegay, A. and Taub, O. (1976). Prostaglandins, 12, 785
Seyberth, H. W., Segre, G. V., Hamet, P., Sweetman, B. J., Potts, J. T., Jr. and Oates, J. A. (1976a). Trans. Ass. Am. Physicians, 89, 92
Seyberth, H. W., Segre, G. V., Morgan, J. L., Sweetman, B. J., Potts, J. T. and Oates, J. A. (1975). New Engl. J. Med., 293, 1278
Seyberth, H. W., Sweetman, B. J., Frölich, J. C. and Oats, J. A. (1976b). Prostaglandins, 11, 381
Tashjian, A. H. Jr., Voelkel, E. F., Levine, L. and Goldhaber, P. (1972). J. Exper. Med., 136, 1329
Verberckmoes, R., Van Damme, B., Clement, J., Amery, A. and Michielsen, P. (1976). Kidney International, 9, 302
Watson, J. T., Pelster, D. R., Sweetman, B. J. and Oates, J. A. (1973). Anal. Chem., 45, 2071
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Copyright information
© 1978 The Contributors
About this chapter
Cite this chapter
Oates, J.A., Seyberth, H.W., Frölich, J.C., Sweetman, B.J., Watson, J.T. (1978). The role of prostaglandins in the pathogenesis of human disease: elucidation with stable isotopic methods. In: Baillie, T.A. (eds) Stable Isotopes. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03328-7_25
Download citation
DOI: https://doi.org/10.1007/978-1-349-03328-7_25
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-03330-0
Online ISBN: 978-1-349-03328-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)