The role of prostaglandins in the pathogenesis of human disease: elucidation with stable isotopic methods
Prostaglandins are extremely potent biogenic compounds and as such are formed in quite small amounts in vivo. The total body production of prostaglandin E2 (PGE2), for example, is less than one µmol per day. Accordingly, the prostaglandins have provided a number of analytical challenges that have been soluble only by the use of selected ion monitoring with mass spectrometry. This is accomplished ultimately by employing stable-isotope-labelled compounds both as internal standards and as carriers.
KeywordsMass Spectrometric Method Silicic Acid Column Bony Metastasis Urine Extract Upjohn Company
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