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Teratological studies on effects of carbon-13 incorporation into preimplantation mouse embryos on development after implantation in vivo and in vitro

  • H. Spielmann
  • H.-G. Eibs
  • U. Jacob
  • D. Nagel
  • C. T. Gregg

Abstract

Since the use of radioactive isotopes is virtually prohibited in studies on drug metabolism in pregnant women and children, stable isotopes have increasingly been employed in investigations where the risk of radioactive damage is unacceptable (Klein and Peterson, 1973; Klein and Klein, 1975). However, the general knowledge of harmful effects of stable isotope enrichment in rapidly developing mammalian systems is rather limited. We have, therefore, studied the effects of high levels of 13C substitution at different stages of embryogenesis on subsequent development of mouse embryos.

Keywords

Stable Isotope Blastocyst Stage Inner Cell Mass Mouse Blastocyst Preimplantation Mouse Embryo 
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Copyright information

© The Contributors 1978

Authors and Affiliations

  • H. Spielmann
    • 1
  • H.-G. Eibs
    • 1
  • U. Jacob
    • 1
  • D. Nagel
    • 1
  • C. T. Gregg
    • 2
  1. 1.Pharmakologisches Institut der Freien Universität BerlinAbteilung EmbryonalpharmakologieWest Germany
  2. 2.Los Alamos Scientific LaboratoryUniversity of CaliforniaLos AlamosUSA

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