Abstract
Since the use of radioactive isotopes is virtually prohibited in studies on drug metabolism in pregnant women and children, stable isotopes have increasingly been employed in investigations where the risk of radioactive damage is unacceptable (Klein and Peterson, 1973; Klein and Klein, 1975). However, the general knowledge of harmful effects of stable isotope enrichment in rapidly developing mammalian systems is rather limited. We have, therefore, studied the effects of high levels of 13C substitution at different stages of embryogenesis on subsequent development of mouse embryos.
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References
Ansell, J. D. and Snow, M. H. L. (1975). J. Embryol. Exp. Morphol., 33, 177
Bell, P. S and Glass, R. H. (1975). Fertil. Steril., 26, 449
Brinster, R. L. (1963). Exp. Cell Res., 32, 205
Donahue, R. P. (1968). J. Exp. Zool., 169, 237
Fisher, D. L. and Smithberg, M. (1972). Teratology, 6, 159
Gregg, C. T. (1974). Europ. J. Clin. Pharmacol., 7, 315
Gregg, C. T., Hutson, J. Y., Prine, J. R., Ott, D. G. and Furchner, J. E. (1973). Life Sci., 13, 775
Gregg, C. T., Ott, D. G., Deaven, L., Spielmann, H., Krowke, R. and Neubert, D. (1975): Proceedings of the Second International Conference on Stable Isotopes, (ed. E. R. Klein and P. D. Klein) Oak Brook, Illinois, U.S.A., p. 61. National Technical Information Service Document CONF-751027
Klein, E. R. and Klein, P. D. (1975). ibid.
Klein, P. D. and Peterson, S. V. (1973): Proceedings of the First International Conference on Stable Isotopes, Argonne, Illinois, U.S.A. National Technical Information Service Document CONF-730525
Lorke, D. (1965). Naunyn-Schmiedebergs Arch. Exp. Path. Pharmakol, 250, 360
Pienkowski, M., Solter, D. and Koprowski, H. (1974). Exp. Cell Res., 85, 424
Rowinski, J., Solter, D. and Koprowski, H. (1975). J. Exp. Zool., 192, 133
Sherman M. I. (1975). Differentiation, 3, 51
Sherman, M. I. and Atienza, S. B. (1975). J. Embryol. Exp. Morphol., 34, 467
Spielmann, H. (1976). Current Topics in Pathology, Vol. 62 (ed. A. Gropp and K. Benirschke). Springer-Verlag, Berlin-Heidelberg, p. 87
Spielmann, H., Eibs, H.-G., Nagel, D. and Gregg, C. T. (1976). Life Sci., 19, 633
Spindle, A. I. and Pedersen, R. A. (1973). J. Exp. Zool., 186, 305
Thomson, J. F. (1963). Biological Effects of Deuterium, Macmillan, New York
Whitten, W. K. (1971). Advances in the Biosciences, Vol. 6 (ed. G. Raspé), Pergamon Press-Vieweg Verlag, New York-Braunschweig, p. 129
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Spielmann, H., Eibs, HG., Jacob, U., Nagel, D., Gregg, C.T. (1978). Teratological studies on effects of carbon-13 incorporation into preimplantation mouse embryos on development after implantation in vivo and in vitro. In: Baillie, T.A. (eds) Stable Isotopes. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03328-7_19
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DOI: https://doi.org/10.1007/978-1-349-03328-7_19
Publisher Name: Palgrave Macmillan, London
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