Discrimination between endogenous and exogenous testosterone in human plasma after oral treatment with testosterone undecanoate using stable-isotope-labelled compounds and mass spectrometric analyses
In this presentation some possibilities, but also some problems, will be described associated with the use of stable-isotope-labelled compounds in metabolic studies. The examples which will be given are taken from a clinical metabolism experiment and a mass fragmentographic assay method for the development of a new orally active testosterone preparation (Nieschlag et al., 1975): testosterone undecanoate, shown in Figure 14.1.
KeywordsIsotope Effect Total Radioactivity Plasma Testosterone Level Deuterium Content Testosterone Undecanoate
Unable to display preview. Download preview PDF.