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Discrimination between endogenous and exogenous testosterone in human plasma after oral treatment with testosterone undecanoate using stable-isotope-labelled compounds and mass spectrometric analyses

  • J. J. de Ridder
  • P. C. J. M. Koppens

Abstract

In this presentation some possibilities, but also some problems, will be described associated with the use of stable-isotope-labelled compounds in metabolic studies. The examples which will be given are taken from a clinical metabolism experiment and a mass fragmentographic assay method for the development of a new orally active testosterone preparation (Nieschlag et al., 1975): testosterone undecanoate, shown in Figure 14.1.

Keywords

Isotope Effect Total Radioactivity Plasma Testosterone Level Deuterium Content Testosterone Undecanoate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Breuer, H. and Siekmann, L. (1975). J. Steroid Biochem. 6, 685CrossRefGoogle Scholar
  2. de Ridder, J. J. and Van Hal, H. J. M. (1976). J. Chromatog., 121, 96CrossRefGoogle Scholar
  3. Nieschlag, E., Mauss, J., Coert, A. and Kiéovié, P. (1975). Acta Endocrinol., 79, 366Google Scholar

Copyright information

© The Contributors 1978

Authors and Affiliations

  • J. J. de Ridder
    • 1
  • P. C. J. M. Koppens
    • 1
  1. 1.Scientific Development GroupOrganon International B.V.OssThe Netherlands

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