Abstract
In this presentation some possibilities, but also some problems, will be described associated with the use of stable-isotope-labelled compounds in metabolic studies. The examples which will be given are taken from a clinical metabolism experiment and a mass fragmentographic assay method for the development of a new orally active testosterone preparation (Nieschlag et al., 1975): testosterone undecanoate, shown in Figure 14.1.
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References
Breuer, H. and Siekmann, L. (1975). J. Steroid Biochem. 6, 685
de Ridder, J. J. and Van Hal, H. J. M. (1976). J. Chromatog., 121, 96
Nieschlag, E., Mauss, J., Coert, A. and Kiéovié, P. (1975). Acta Endocrinol., 79, 366
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de Ridder, J.J., Koppens, P.C.J.M. (1978). Discrimination between endogenous and exogenous testosterone in human plasma after oral treatment with testosterone undecanoate using stable-isotope-labelled compounds and mass spectrometric analyses. In: Baillie, T.A. (eds) Stable Isotopes. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03328-7_14
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DOI: https://doi.org/10.1007/978-1-349-03328-7_14
Publisher Name: Palgrave Macmillan, London
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Online ISBN: 978-1-349-03328-7
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