Abstract
Phenacetin (acetophenetidine) is a minor analgesic which has been associated with various toxic effects, including methaemoglobinaemia and haemolysis (Beutler, 1969) and renal damage (Abel, 1970). Phenacetin causes both methaemoglobinaemia and mild hepatic necrosis in hamsters. As with the related analgesic, acetaminophen, phenacetin-induced necrosis is potentiated by 3-methylcholanthrene pretreatment. The severity of necrosis parallels the magnitude of the covalent binding of an arylating metabolite of phenacetin to hepatic proteins and depletion of hepatic glutathione by the formation of a glutathione adduct (Mitchell et al., 1975).
Dr A. R. Buckpitt was supported by the National Institute of Heart, Lung, and Blood Fellowship No. 1 F32 HL05236 01.
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Nelson, S.D., Garland, W.A., Mitchell, J.R., Vaishnev, Y., Statham, C.N., Buckpitt, A.R. (1978). The use of stable isotopes to better define toxic metabolic pathways of p-hydroxyacetanilide (acetaminophen) and p-ethoxyacetanilide (phenacetin). In: Baillie, T.A. (eds) Stable Isotopes. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03328-7_12
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DOI: https://doi.org/10.1007/978-1-349-03328-7_12
Publisher Name: Palgrave Macmillan, London
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