The molecular basis for the inhibitory action of 6-(arylhydrazino)-pyrimidines on the replication-specific DNA polymerase III of Gram-positive bacteria
6-(p-Hydroxyphenylazo) uracil (HPUra, Fig. 8.1), 6-(p-hydroxy phenylazo) 2-amino 4 oxo pyrimidine (HPlsocytosine, Fig. 8.1) and several related 6 (arylazo)pyrimidines were conceived and synthesised by Bernard Langley of Imperial Chemical Industries, Ltd in the early 1960s. Langley and his colleagues, in their initial studies of biological activity of the arylazopyrimidines, observed that they were potent inhibitors of the growth of Gram-positive bacteria and that they possessed little or no toxicity for Gram-negative organisms or for animal cells.
KeywordsAryl Group Hydroxyl Terminus Aryl Moiety Imperial Chemical Industry Prime Terminus
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