The molecular basis for the inhibitory action of 6-(arylhydrazino)-pyrimidines on the replication-specific DNA polymerase III of Gram-positive bacteria

  • Neal C. Brown
  • George E. Wright
Part of the Biological Council book series (BCSDA)

Abstract

6-(p-Hydroxyphenylazo) uracil (HPUra, Fig. 8.1), 6-(p-hydroxy phenylazo) 2-amino 4 oxo pyrimidine (HPlsocytosine, Fig. 8.1) and several related 6 (arylazo)pyrimidines were conceived and synthesised by Bernard Langley of Imperial Chemical Industries, Ltd in the early 1960s. Langley and his colleagues, in their initial studies of biological activity of the arylazopyrimidines, observed that they were potent inhibitors of the growth of Gram-positive bacteria and that they possessed little or no toxicity for Gram-negative organisms or for animal cells.

Keywords

Phenyl Adenine Benzyl Pyrimidine Purine 

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Copyright information

© Institute of Biology Endowment Trust Fund 1977

Authors and Affiliations

  • Neal C. Brown
    • 1
  • George E. Wright
    • 1
  1. 1.Department of PharmacologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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