Abstract
Dihydrofolate reductase (5, 6, 7, 8-tetrahydrofolate:NADP+ oxidoreductase, E.C.1.5.1.3), an enzyme found in the vast majority of both prokaryotic and eukaryotic organisms, catalyses the reduction of dihydrofolate to tetrahydrofolate, using NADPH as coenzyme:
The product of this reaction, tetrahydrofolate, plays a vital role in intermediary metabolism, acting as a ‘carrier’ of one-carbon fragments in the biosynthesis of a number of amino acids, thymidylate and purines (for a review, see Blakley, 1969).
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© 1977 Institute of Biology Endowment Trust Fund
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Roberts, G.C.K. (1977). Substrate and inhibitor binding to dihydrofolate reductase. In: Roberts, G.C.K. (eds) Drug Action at the Molecular Level. Biological Council. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03230-3_7
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DOI: https://doi.org/10.1007/978-1-349-03230-3_7
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