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Structure and function of carbonic anhydrase: comparative studies of sulphonamide binding to human erythrocyte carbonic anhydrases B and C

  • K. K. Kannan
  • I. Vaara
  • B. Notstrand
  • S. Lövgren
  • A. Boren
  • K. Fridborg
  • M. Petef
Part of the Biological Council book series (BCSDA)

Abstract

Soon after the discovery of carbonic anhydrase from bovine erythrocytes (E.C.4.2.1.1), which catalyses the reaction
by Meldrum and Roughton (1932) it was shown by Mann and Keilin (1940) that certain sulphonamides were specific and potent inhibitors of this enzyme. It has been well documented (see Maren, 1967, for an extensive review on inhibition and physiology, and Lindskog et al. 1971, and Coleman, 1971, for general reviews on carbonic anhydrases) that aromatic and heterocyclic sulphonamides with unsubstituted R—SO2 NH2 groups constitute a class of powerful inhibitors, while aliphatic sulphonamides are poor inhibitors of the carbonic anhydrases.

Keywords

Carbonic Anhydrases Complete Amino Acid Sequence Active Site Region ORTEP Drawing Swedish Natural Science Research Council 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andersson, B., Nyman, P. O. and Strid, L. (1972). Biochem. Biophys. Res. Comm., 48, 670PubMedCrossRefGoogle Scholar
  2. Armstrong, J. McD., Myers, D. V., Verpoorte, J. A. and Edsall, J. T. (1966). J. Biot Chem., 241, 5137Google Scholar
  3. Bergstén, P. C., Vaara, I., Lövgren, S., Liljas, A., Kannan, K. K. and Bengtsson, U. (1972). In Proceedings of’the Alfred Benzon Symposium IV (ed. M. Rorth and P. Astrup), Copenhagen, Munksgaard, p. 363Google Scholar
  4. Blow, D. M. and Crick, F. H. C. (1959). Acta Cryst., 12, 794CrossRefGoogle Scholar
  5. Campbell, I. D., Lindskog, S. and White, A. I. (1974). J. Mol. Biol, 90, 469PubMedCrossRefGoogle Scholar
  6. Campbell, I. D., Lindskog, S. and White, A. I. (1975). J. Mol. Biol., 98, 597PubMedCrossRefGoogle Scholar
  7. Coleman, J. E. (1971). Progr. Bioorg. Chem., 1, 159Google Scholar
  8. Dickerson, R. E., Kendrew, J. S. and Strandberg, B. E. (1961). Acta Cryst., 14, 1188CrossRefGoogle Scholar
  9. Göthe, P. O. and Nyman, P. O. (1972). FEBS Lett., 21, 159PubMedCrossRefGoogle Scholar
  10. Harding, M. M. and Cole, S. J. (1963). Acta Cryst., 16, 643CrossRefGoogle Scholar
  11. Henderson, L. E., Henriksson, O. and Nyman, P. 0. (1973). Biochem. Biophys. Res. Comm., 52, 1388PubMedCrossRefGoogle Scholar
  12. Henriksson, D. (1975). Dissertation, Department of Biochemistry, Gothenburg UniversityGoogle Scholar
  13. Järup, L., Kannan, K. K., Liljas, A. and Strandberg, B. (1970). Computer Programs Biomed., 1, 74CrossRefGoogle Scholar
  14. Johnson, C. K. (1965). Oak Ridge National Lab. Publ.Google Scholar
  15. Kakeya, N., Aoki, M., Kameda, A. and Yata, N. (1969). Chem. Pharm. BulL, 17, 1010PubMedCrossRefGoogle Scholar
  16. Kannan, K. K., Fridborg, K., Bergstén, P. C., Liljas, A., Lövgren, S., Petef, M., Strandberg, B., Vaara, I., Adler, L., Falkbring, S. O., Göthe, P. O. and Nyman, P. O. (1972). J. Mol. Biol., 63, 601PubMedCrossRefGoogle Scholar
  17. Kannan, K. K., Liljas, A., Vaara, I., Bergstén, P. C., Fridborg, K., Lövgren, S., Strandberg, B., Bengtsson, U., Carlbom, U., Järup, L. and Petef, M. (1971). Cold Spring Harbor Symposia on Quant. Biology, 36, 221CrossRefGoogle Scholar
  18. Kannan, K. K., Notstrand, B., Fridborg, K., Lövgren, S., Ohlsson, A. and Petef, M. (1975). Proc. Nat. Acad. Sci. U.S.A., 72, 51CrossRefGoogle Scholar
  19. Kannan, K. K., Petef, M., Fridborg, K., Cid-Dresdner, H. and Lövgren, S. (1977). FEBS Lett., 73, 115PubMedCrossRefGoogle Scholar
  20. Kretzinger, R. H., Cotton, F. A. and Bryan, R. F. (1963). Acta Cryst., 16, 651CrossRefGoogle Scholar
  21. Kuang-Tzu, D. L. and Deutsch, H. F. (1973). J. BioL Chem., 248, 1885Google Scholar
  22. Liljas, A., Kannan, K. K., Bergstén, P. C., Vaara, I.,, Fridborg, D., Strandberg, B., Carlbom, U., Järup, L., Lövgren, S. and Petef, M. (1972). Nature New BioL, 235, 131PubMedCrossRefGoogle Scholar
  23. Lindskog, S., Henderson, I. E., Kannan, K. K., Liljas, A., Nyman, P. 0. and Strandberg, B. (1971). In The Enzymes (ed. P. D. Boyer ), 3rd edn, Vol. 5, New York, Academic Press, p. 387Google Scholar
  24. Mann, T., and Keilin, D. (1940). Nature (London), 146, 164CrossRefGoogle Scholar
  25. Maren, T. H. (1967). PhysioL Rev. 47 595, and references thereinPubMedGoogle Scholar
  26. Marriq, C., Sciaky, M., Giraud, N., Foveau, D. and Laurent-Tabusse, G. (1973). Biochemie, 55, 1361CrossRefGoogle Scholar
  27. Meldrum, N. U. and Roughton, F. J. W. (1932). J. Physiol. (London) 75, 4P and 15PGoogle Scholar
  28. Notstrand, B., Vaara, I. and Kannan, K. K. (1975). In Isoenzymes I, Molecular Structure (ed. C. L. Markert), New York, Academic Press, p. 575Google Scholar
  29. Nyman, P. O. (1961). Biochem. Biophys. Acta, 52, 1PubMedCrossRefGoogle Scholar
  30. Richards, F. M. (1968). J.Mol. Biol., 37, 225PubMedCrossRefGoogle Scholar
  31. Strandberg, B., Tilander, B., Fridborg, K., Lindskog, S. and Nyman, P. O. (1962). J.Mol.Biol., 5, 583PubMedCrossRefGoogle Scholar
  32. Tashian, R. E. (1975). In Isoenzymes I, Molecular Structure (ed. C. L. Markert), New York, Academic PressGoogle Scholar
  33. Taylor, P. W., King, R. W. and Burgen, A. S. V. (1970). Biochemistry, 9, 3894PubMedCrossRefGoogle Scholar
  34. Vaara, I. Lövgren, S., Liljas, A., Kannan, K. K. and Bergstén, P-C. (1972). In Second Int. Conference on Red Cell Metabolism and Function, Ann ArborGoogle Scholar
  35. Woolley, P. (1975). Nature (London) 258 677, and references thereinCrossRefGoogle Scholar

Copyright information

© Institute of Biology Endowment Trust Fund 1977

Authors and Affiliations

  • K. K. Kannan
    • 1
  • I. Vaara
    • 1
  • B. Notstrand
    • 1
  • S. Lövgren
    • 1
  • A. Boren
    • 1
  • K. Fridborg
    • 1
  • M. Petef
    • 1
  1. 1.Department of Molecular Biology, Wallenberg LaboratoryUppsala UniversityUppsalaSweden

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