Interaction of ouabain and cassaine with Na+ + K+ — ATPase and its relationship to their inotropic actions

  • Thomas Tobin
  • Tai Akera
Part of the Biological Council book series (BCSDA)

Abstract

Sodium — potassium — activated ATPase (ATP phosphohydrolase E.C. 3.6.1.3) is a membrane-bound enzyme which is thought to be closely related to, if not identical with, the sodium pump activity of cell membranes. In vivo, this enzyme pumps sodium out of and potassium into the cell and it has therefore, during its transport cycle, access to both sides of the cell membrane (Post et al. 1969). The transport function of Na+ + K+ — ATPase is required for volume control in the cell, but it also subserves many other cellular functions (Post, 1968).

Keywords

Hydrolysis EDTA Amide Alkaloid Catalase 

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Copyright information

© Institute of Biology Endowment Trust Fund 1977

Authors and Affiliations

  • Thomas Tobin
    • 1
  • Tai Akera
    • 2
  1. 1.Equine Drug Research Program, Department of Veterinary ScienceUniversity of KentuckyLexingtonUSA
  2. 2.Department of PharmacologyMichigan State UniversityEast LansingUSA

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