Interaction of ouabain and cassaine with Na+ + K+ — ATPase and its relationship to their inotropic actions
Sodium — potassium — activated ATPase (ATP phosphohydrolase E.C. 126.96.36.199) is a membrane-bound enzyme which is thought to be closely related to, if not identical with, the sodium pump activity of cell membranes. In vivo, this enzyme pumps sodium out of and potassium into the cell and it has therefore, during its transport cycle, access to both sides of the cell membrane (Post et al. 1969). The transport function of Na+ + K+ — ATPase is required for volume control in the cell, but it also subserves many other cellular functions (Post, 1968).
KeywordsCardiac Glycoside Positive Inotropic Effect Perfuse Heart Inotropic Response Ouabain Binding
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