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The receptor site for chloramphenicol in vitro and in vivo

  • Olaf Pongs
Part of the Biological Council book series (BCSDA)

Abstract

Chloramphenicol inhibits protein synthesis in Gram-negative and Gram-positive bacteria as well as in chloroplasts, blue-green algae and mitochondria (for a review, see Pestka, 1971). It was the first antibiotic to be synthesised by chemical methods (Controulis, Rebstock and Crooks, 1949). The molecule has a relatively simple structure, which consists of a propanediol moiety (III), carrying a p-nitrobenzene side-chain (I) and a dichloroacetyl side-chain (II) (Fig. 10.1).

Keywords

Ribosomal Protein Receptor Site Affinity Probe Peptidyltransferase Centre Affinity Labelling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Biology Endowment Trust Fund 1977

Authors and Affiliations

  • Olaf Pongs
    • 1
  1. 1.MRC Laboratory of Molecular BiologyCambridgeUK

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