The receptor site for chloramphenicol in vitro and in vivo
Chloramphenicol inhibits protein synthesis in Gram-negative and Gram-positive bacteria as well as in chloroplasts, blue-green algae and mitochondria (for a review, see Pestka, 1971). It was the first antibiotic to be synthesised by chemical methods (Controulis, Rebstock and Crooks, 1949). The molecule has a relatively simple structure, which consists of a propanediol moiety (III), carrying a p-nitrobenzene side-chain (I) and a dichloroacetyl side-chain (II) (Fig. 10.1).
KeywordsRibosomal Protein Receptor Site Affinity Probe Peptidyltransferase Centre Affinity Labelling
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