Chemical constitution and prototropic equilibria in structure — activity analysis

  • C. R. Ganellin
Part of the Biological Council book series (BCSDA)


It seems to me appropriate that the first paper in a symposium on Drug Action at the Molecular Level should discuss the chemical characterisation of drug molecules. Attempts to establish why drug substances exert particular biological effects is a pursuit of long standing (for discussion of this see Sexton, 1963; Barlow, 1964; Albert, 1968; Burger, 1970). As our chemical understanding has advanced, we have become more sophisticated in the way we view the chemical constitution of drug molecules and in the way we attempt to relate this to biological action.


Activity Analysis Drug Molecule Imidazole Ring Substituent Effect Constitutive Property 
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© Institute of Biology Endowment Trust Fund 1977

Authors and Affiliations

  • C. R. Ganellin
    • 1
  1. 1.The Research Institute, Smith Kline & French Laboratories LtdHertfordshireUK

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