The fractional test meal was criticised because the meal itself diluted the gastric secretions. To overcome this difficulty the meal was replaced by a non-oral stimulus. Ehrmann tried pilocarpine in 1912357 but found it produced too many side-effects. In 1920 Popielski932 showed that histamine stimulated the gastric secretion of acid in the dog, and 2 years later Carnot, Koskowski and Libert219 elicited a similar response in man. However, a ‘fractional test meal’ using histamine had all the disadvantages of the other test meals.274


Gastric Secretion Acid Output Maximal Acid Output Maximal Stimulus Histamine Dihydrochloride 
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Copyright information

© J. H. Baron 1978

Authors and Affiliations

  • J. H. Baron
    • 1
    • 2
  1. 1.Departments of Surgery and MedicineRoyal Postgraduate Medical School and Hammersmith HospitalUK
  2. 2.St Charles’ HospitalSt Mary’s Hospital Medical SchoolLondonUK

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