The fractional test meal was criticised because the meal itself diluted the gastric secretions. To overcome this difficulty the meal was replaced by a non-oral stimulus. Ehrmann tried pilocarpine in 1912357 but found it produced too many side-effects. In 1920 Popielski932 showed that histamine stimulated the gastric secretion of acid in the dog, and 2 years later Carnot, Koskowski and Libert219 elicited a similar response in man. However, a ‘fractional test meal’ using histamine had all the disadvantages of the other test meals.274
KeywordsGastric Secretion Acid Output Maximal Acid Output Maximal Stimulus Histamine Dihydrochloride
Unable to display preview. Download preview PDF.