There was considerable dispute in the nineteenth century whether, as Beaumont and Pavlov suggested, the stomach secreted in the absence of food. In 1912 Carlson produced the first careful data on basal interdigestive secretion. He studied patients with gastric fistulae (2–50 ml/h)212–13 as well as normal subjects after overnight or prolonged fasting (25–224 ml/h, the usual range being 30–60 ml/h).214 In 1923 Carlson stated: ‘we practically never fail to demonstrate a continuous gastric secretion of relatively low acidity even though the observation be continued for hours.’215
KeywordsDuodenal Ulcer Gastric Secretion Acid Output Basal Secretion Prolonged Fasting
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