Adrenocortical cell receptors for corticotrophin
It is evident that the mechanism of ACTH action on the fat cell exhibits important differences from that by which it acts on the adrenocortical cell. For example, unlike the situation in the fat cell, actinomycin D in a variety of doses has been shown to be inhibitory for steroidogenesis by adrenal cells influenced by a wide range of ACTH concentrations (Schulster, 1974). Nevertheless, it is interesting to compare the actions of this hormone on these different cells in a critical evaluation of the role of cyclic AMP in hormone action.
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