The ACTH-fat cell system as a model for hormone-receptor interaction

  • Ursula Lang
  • R. Schwyzer
Part of the Biological Council book series (BCSDA)


Hormones are considered to involve specific, reversible interactions with specialised components of the target cells, the so-called receptors (Hofmann, Wingender and Finn, 1970; Cuatrecasas, 1971; Kono and Crofford, 1972; Sica et al., 1973). Strong evidence indicates that the primary sites of action of catecholamines and polypeptide hormones are located in the cell plasma membrane, whereas steroids penetrate into the cells (Birnbaumer and Rodbell, 1969; Jensen and De Sombre, 1972). The association of the hormone with specific sites or receptors is probably the basic mechanism of hormone recognition of the target cell and presumably represents the first step in hormonal stimulation.


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  1. Bär, H.-P. and Hechter, O. (1969). Proc. Nat. Acad. Sci. U.S., 63, 350CrossRefGoogle Scholar
  2. Birnbaumer, L. and Rodbell, M. (1969). J. Biol. Chem. 244, 3477PubMedGoogle Scholar
  3. Braun, T. and Hechter, O. (1970). Adipose Tissue (ed. B. Jeanrenaud and D. Hepp), Georg Thieme, Stuttgart; Academic Press, New York, p. 11Google Scholar
  4. Cuatrecasas, P. (1971). Proc. Nat. Acad. Sci. U.S., 68, 1264CrossRefGoogle Scholar
  5. Cuatrecasas, P. (1972). J. Biol. Chem., 247, 1980PubMedGoogle Scholar
  6. Gammeltoft, S. and Gliemann, J. (1973). Biochim. Biophys. Acta, 320, 16PubMedCrossRefGoogle Scholar
  7. Guthrow, C. E. Jr., Allen, J. E. and Rasmussen, H. (1972). J. Biol. Chem., 247, 8145PubMedGoogle Scholar
  8. Hofmann, K., Wingender, W. and Finn, F. M. (1970). Proc. Nat. Acad. Sci. U.S., 67, 829CrossRefGoogle Scholar
  9. Jensen, E. V. and De Sombre, E. R. (1972). Ann. Rev. Biochem. 41, 203PubMedCrossRefGoogle Scholar
  10. Kono, T. and Crofford, O. B. (1972). The Role of Membranes in Metabolic Regulation (ed. M. A. Mehlmann and R. W. Hanson), Academic Press, New York, p. 237CrossRefGoogle Scholar
  11. Lang, U. (1973). Dissertation No. 5215, Swiss Federal Institute of Technology, CH-8006 Zürich, SwitzerlandGoogle Scholar
  12. Lang, U. and Schwyzer, R. (1972). FEBS Letters, 21, 91PubMedCrossRefGoogle Scholar
  13. Lefkowitz, R. J. (1972). The Role of Membranes in Metabolic Regulation (ed. M. A. Mehlmann and R. W. Hanson), Academic Press, New York, p. 261CrossRefGoogle Scholar
  14. Lefkowitz, R. J., Roth, J. and Pastan, I. (1971). Ann. N. Y. Acad. Sci. 185, 195PubMedCrossRefGoogle Scholar
  15. Rodbell, M. (1964). J. Biol. Chem., 239, 375PubMedGoogle Scholar
  16. Rodbell, M. (1967). J. Biol. Chem., 242, 574Google Scholar
  17. Schwyzer, R. and Kappeler, H. (1961). Helv. Chim. Acta, 44, 1991CrossRefGoogle Scholar
  18. Schwyzer, R., Karlaganis, G., Vogel, R. and Lang, U. (1973). J. Intern. Res. Commun., 1, 9Google Scholar
  19. Sica, V., Nola, E., Parikh, I., Puca, G. A. and Cuatrecasas, P. (1973). Nature New Biol., 244, 36PubMedCrossRefGoogle Scholar
  20. Vaughan, M. (1972). Insulin Action, Academic Press, London, New YorkGoogle Scholar

Copyright information

© Institute of Biology Endowment Trust Fund 1976

Authors and Affiliations

  • Ursula Lang
    • 1
  • R. Schwyzer
    • 1
  1. 1.Institut für Molekularbiologie und BiophysikEidgenössische Technische HochschuleZürichSwitzerland

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