The ACTH-fat cell system as a model for hormone-receptor interaction
Hormones are considered to involve specific, reversible interactions with specialised components of the target cells, the so-called receptors (Hofmann, Wingender and Finn, 1970; Cuatrecasas, 1971; Kono and Crofford, 1972; Sica et al., 1973). Strong evidence indicates that the primary sites of action of catecholamines and polypeptide hormones are located in the cell plasma membrane, whereas steroids penetrate into the cells (Birnbaumer and Rodbell, 1969; Jensen and De Sombre, 1972). The association of the hormone with specific sites or receptors is probably the basic mechanism of hormone recognition of the target cell and presumably represents the first step in hormonal stimulation.
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