The applicability of the deconvolution technique after repeated administration of labelled serum albumin

Abstract

Compartmental analysis, deconvolution as well as other techniques, can be applied for quantification of serum albumin kinetics and catabolism, starting from plasma and whole-body or excretion curves under steady-state conditions^1–3. As demonstrated previously, the main advantage of the deconvolution technique lies in the fact that the analysis starts from the beginning of the curves measured, when measurement errors are relatively low. It has been shown that the weighting function, G(t), of albumin transfer from intra- to extravascular spaces after labelled albumin input into the intravascular pool at time t = 0 has some important properties: its initial value G(0) equals the overall fractional albumin outflow from intra- to extravascular spaces, and its integral from zero to infinity equals the ratio of extravascular to intravascular albumin mass.