Abstract
The subject of the present paper is an application of the deconvolution approach to the study of extravascular (EV) albumin space. The method developed enables us to estimate not only the rate of transfer outside the vascular space and the total EV mass of the protein, but also the mass of EV albumin exchanging with the intravascular protein in a given time interval. This last parameter can be obtained using data from short-term tracer experiments (48–24 hours or less), as its computation does not imply extrapolation.
Partly supported by Public Health Service U.S.A., Contract No. PH-43-68-707.
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References
Bianchi, R., Mariani, G. and Pilo, A. (1972) Short-term measurement of plasma protein catabolism in man. In Radioaktive Isotope in Klinik und Forschung, 10ed., K. Fellinger and R. Höfer, eds., München, p. 94
Bianchi, R., Mariani, G., Pilo, A., Toni, M. G. and Donato, L. (1973) Short-term determination of plasma protein turnover by a two tracer technique using plasma only or plasma and urine data. In Protein Turnover ASP, Amsterdam, p. 47
Bianchi, R., Mariani, G., Pilo, A. and Toni, M. G. Short-term determination of serum albumin catabolism in man from plasma data only. J. Nucl. Biol. Med., 17 (1973), 117
Vitek, F., Bianchi, R., Mancini, P. and Donato, L. (1969) Deconvolution techniques for the analysis of short-term metabolic studies with radioiodinated albumin. In Physiology and Pathophysiology of Plasma Protein Metabolism, G. Birke, R. Norberg and L. O. Plantin, eds., Pergamon Press, p. 29
Bianchi, R., Federighi, G., Giagnoni, P., Giordani, R. Navalesi, R. and Donato, L. (1969) Patterns of serum albumin metabolism in renal diseases. In Physiology and Pathophysiology of Plasma Protein Metabolism, G. Birke, R. Norberg and L. O. Plantin, eds., Pergamon Press, p. 195
Zierler, K. (1964) Basic aspects of kinetic theory as applied to tracer-distribution studies. In Dynamic Studies with Radioisotopes, U.A.S.E.C., p. 55
Bianchi, R., Mariani, G., Pilo, A. and Toni, M. G. Measurement of albumin extravascular transfer rate and distribution from short term two tracer studies in man. In Radioaktive Isotopes in Klinik and Forschung, 11ed., R. Hofer, ed., Munich, p. 220
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Bianchi, R., Mariani, G., Pilo, A., Toni, M.G. (1976). Albumin distribution from short-term tracer studies in man. In: Bianchi, R., Mariani, G., McFarlane, A.S. (eds) Plasma Protein Turnover. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-02644-9_7
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DOI: https://doi.org/10.1007/978-1-349-02644-9_7
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-02646-3
Online ISBN: 978-1-349-02644-9
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