Hormonal regulation of net haptoglobin biosynthesis in the isolated perfused rat liver
Haptoglobin, discovered and first described by Polonowski and Jayle1 has been extensively studied over the last three decades. However, it was not until 19602 that Murray and Connell noted that subcutaneous injection of turpentine in rabbits was followed within 48 h by a marked rise in the serum haptoglobin level. Later observations of puromycin treated rats were consistent with the view that the increased level of haptoglobin was largely the result of increased synthesis in overall response to the subcutaneous inflammation. The pattern of increase in plasma haptoglobin level in response to the experimental injury has since been observed to occur in a variety of higher animals including the rat, dog, and human in response to diverse kinds of injury3. So characteristic has been this stereotyped response that haptoglobin is now reckoned among the acute phase plasma proteins.
KeywordsGrowth Hormone Liver Donor Acute Phase Protein Amino Acid Mixture Label Amino Acid
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