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Increased fibrin formation with tumours and its genesis

  • J. J. Franks
  • S. G. Gordon
  • B. Kao
  • T. Sullivan
  • D. Kirch

Abstract

O’Meara and his associates1 – 5 and Clarke6 showed over ten years ago that malignant tissues produce a lipid containing coagulative factor which can diffuse out of cells, initiate coagulation in and around tumour tissue and lay down fibrin, particularly at the tumour margin. They speculated that such fibrin deposition could enhance the invasiveness of tumours, both locally and at metastatic sites, by providing a lattice work for new growth. Other workers using histopathologic7,8 and radioisotopic techniques9 – 14 have confirmed that fibrin deposition does occur in many animal and human neoplasms. Whether there is also a relationship between a tumour-produced coagulative factor and the increased incidence of vascular thrombosis seen in cancer patients is not known but the clotting system is certainly disturbed in many of these patients who have high levels of fibrinogen, platelets, factors V and VIII, and fibrin split products as well as other abnormalities indicative of a ‘hypercoagulable state’15 – 19.

Keywords

Compartment Model Plasma Fibrinogen Procoagulant Activity Fibrin Formation Catabolic Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    O’Meara, R. A. Q and Jackson, R. D. Cytological observations on carcinoma. Irish J. Med. Sci., 391 (1958), 327CrossRefGoogle Scholar
  2. 2.
    Boggust, W. A., O’Meara, R. A. Q and Thornes, R. D. The coagulative factors of normal human and cancer tissue. Biochem. J., 80 (1961), 32Google Scholar
  3. 3.
    O’Meara, R. A. Q and Thornes, R. D. Some properties of the cancer coagulative factor. Irish J. Med. Sci., 423 (1961), 106CrossRefGoogle Scholar
  4. 4.
    Boggust, W. A., O’Meara, R. A. Q and Thornes, R. D. The coagulative factors of normal human and human cancer tissue. Irish J. Med. Sci., 447 (1963), 131–144CrossRefGoogle Scholar
  5. 5.
    Boggust, W. A., O’Meara, R. A. Q and Fullerton, W. W. Diffusible thromboplastins of human cancer and chorion tissue. Europ. J. Cancer, 3 (1968), 467CrossRefGoogle Scholar
  6. 6.
    Clarke, N. Intracellular location of tissue thromboplastin and possible relation to fibrin deposits in human neoplasms. Nature, 205 (1965), 608CrossRefGoogle Scholar
  7. 7.
    Hiramoto, R., Bernecky, J., Jurandowski, J. and Pressman, D. Fibrin in human tumours. Cancer Research, 20 (1960), 592Google Scholar
  8. 8.
    Ogura, T., Tatsuta, M. and Yamamura, Y. Localisation of fibrinogen in the tumour tissue. G.A.N.N., 58 (1967), 403Google Scholar
  9. 9.
    Day, E. D., Planinsek, J. A. and Pressman, D. Localisation in vivo of radioiodinated anti-rat-fibrin antibodies and radioiodinated rat fibrinogen in the Murphy rat lymphosarcoma and in other transplantable rat tumours. J. Natl. Cancer Inst., 22 (1959), 413Google Scholar
  10. 10.
    Day, E. D., Planinsek, J. A. and Pressman, D. Localisation of radioiodinated rat fibrinogen in transplanted rat tumors. J. Natl. Cancer Inst., 23 (1959), 799Google Scholar
  11. 11.
    Dewey, W. C., Bale, W. F., Rose, R. G. and Marack, D. Localisation of antifibrin antibodies in human tumors. Acta Union Int, Cancer, 19 (1963), 185Google Scholar
  12. 12.
    Shaeffer, J. R. Interference in localisation of I131 fibrinogen in rat tumours by anticoagulants. Am. J. Phys., 206 (1964), 573Google Scholar
  13. 13.
    Spar, I. L., Bale, W. F., Marrack, D., Dewey, W. C., McCardle, R. J. and Harper, P. V. 131I-labelled antibodies to human fibrinogen: Diagnostic studies and therapeutic trials. Cancer, 20 (1967), 865CrossRefGoogle Scholar
  14. 14.
    Riccioni, N. Diagnosis of malignant lesions of the liver by radiocolloid and 131I fibrinogen. J. Biol. Nucl. Med., 13 (1969), 160Google Scholar
  15. 15.
    Fumarola, D. and DelBuono, G. The blood coagulation pattern in malignancies. Prog. Med. Napoli, 14 (1958), 327Google Scholar
  16. 16.
    Amundsen, M. A., Spittell, J. A., Thompson, J. H. and Owen, C. A. Hypercoagulability associated with malignant disease and with the postoperative state: Evidence for elevated levels of antihemophilic globulin. Ann. Intern. Med., 58 (1963), 608CrossRefGoogle Scholar
  17. 17.
    Miller, S. P., Sanchez-Avalos, Stefanski, T. and Zukerman, L. Coagulation disorders in cancer I. Clinical and laboratory studies. Cancer, 20 (1967), 1452CrossRefGoogle Scholar
  18. 18.
    Waterbury, L. S. and Hampton, J. W. Hypercoagulability with malignancy. Angiology 18 (1967), 197CrossRefGoogle Scholar
  19. 19.
    Davis, R. B., Theologides, A. and Kennedy, B. J. Comparative studies of blood coagulation and platelet aggregation in patients with cancer and nonmalignant diseases. Ann. Intern. Med., 71 (1969), 67CrossRefGoogle Scholar
  20. 20.
    Atencio, A. C., Bailey, H. R. and Reeve, E. B. Studies on the metabolism and distribution of fibrinogen in young and older rabbits I. Methods and models. J. Lab. & Clin. Med., 66 (1965), 1Google Scholar
  21. 21.
    Takeda, Y. Studies of the metabolism and distribution of fibrinogen in healthy men with autologous 1251-labelled fibrinogen. J. Clin. Invest., 45 (1966) 103CrossRefGoogle Scholar
  22. 22.
    Wood, S., Jr. Experimental studies of the intravascular dissemination of ascitic V2 carcinoma cells in the rabbit, with special reference to fibrinogen and fibrinolytic agents. Bulletin Swiss Acad. Med. Sci., 20 (1964), 92Google Scholar
  23. 23.
    Monasterio, G., Becchini, M. F. and Riccioni, N. Radioiodinated (1131 and I125) fibrinogen for the detection of malignant tumours in man. Med. Radioisotope Scanning, 2 (1964), 159Google Scholar
  24. 24.
    Monasterio, G., Becchini, M. F. and Riccioni, N. Detection of tumours in man by means of I131-fibrinogen. Excerpta Med. Internat. Cong. Ser., No. 105 (1965), 1270Google Scholar
  25. 25.
    Riccioni, N., Becchini, M. F. and Aloisi, M. Differentiation of malignant neoplasms from other lesions using radioactive fibrinogen. Minerva Nucleare, 9 (1965), 451Google Scholar
  26. 26.
    Riccioni, N., DeRenzi, G. Becchini, M. F. and Bartorelli, A. The time course of radiofibrinogen uptake in the I.R.E. sarcoma and in acute inflammatory process as induced in rats. Minerva Nucleare, 9 (1965), 250Google Scholar
  27. 27.
    Riccioni, N., Becchini, M. F., Vitek, F. and Donato, L. (1966). Analog computer study of the kinetics of extravascular distribution of 131I-labelled plasma proteins in normal and tumoural tissues. Proc. Conf. on problems connected with the preparation and use of labelled proteins in tracer studies, Pisa, Italy, January 17–19, 193–198.Google Scholar
  28. 28.
    Gordon, S. G. Partial characterisation of cancer thrombogenic factor (CTF) activity. Fed. Proc., 33 (1974), 209 (Abstract)Google Scholar
  29. 29.
    Franks, J. J. and Gordon, S. G. Some properties of cancer thrombogenic factor (CTF). Fed. Proc., (1974), 209 (Abstract)Google Scholar
  30. 1.
    Monasterio, G., Becchini, M. F. and Riccioni, N. (1964). Radioiodinated (131I and 125I) fibrinogen for the detection of malignant tumours in man. In Medical Radioisotope Scanning, Vol. II, IAEA, Vienna, p. 159Google Scholar
  31. 2.
    Riccioni, N., De Renzi, G., Becchini, M. F. and Bartorelli, A. The time course of radiofibrinogen uptake in the I.R.E. sarcoma and in acute inflammatory process as induced in rats. Min. Nucl., 9 (1965), 250Google Scholar
  32. 3.
    Riccioni, N., Becchini, M. F., Vitek, F. and Donato, L. (1966). Analog computer study of the kinetics of extravascular distribution of 131I labelled plasma proteins in normal and tumoural tissues. In Labelled Proteins in Tracer Studies, L. Donato, G. Milhaud and J. Sirchis, eds., EURATOM 2950.d,f,e, Brussels, p. 193Google Scholar
  33. 4.
    Bale, W. F., Spar, I. L. and Goodland, R. L. (1960). Experimental radiation therapy of tumours using 131I-carrying antibodies to fibrin. University of Rochester Atomic Energy Project Report, UR-567Google Scholar
  34. 5.
    Genton, E. Personal communicationGoogle Scholar
  35. 6.
    Straub, P. W. Chronic intravascular coagulation. Clinical spectrum and diagnostic criteria, with special emphasis on metabolism, distribution and localisation of 131I fibrinogen. Acta Med. Scand., Supp., 1 (1971), 526Google Scholar

Copyright information

© The Contributors 1976

Authors and Affiliations

  • J. J. Franks
  • S. G. Gordon
  • B. Kao
  • T. Sullivan
  • D. Kirch

There are no affiliations available

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