The acute phase plasma proteins

  • A. H. Gordon


During the last four years increasing attention has been given to those plasma proteins which increase or decrease in concentration after trauma or during acute infections. As a result of such studies it has become apparent that additions must be made to the category of those which increase in concentration, usually referred to as ‘acute phase proteins’, or ‘acute phase reactants’ (APRs). Recent data on APRs have been summarised by Koj1. Thus information is now available that certain proteins present in plasma after injury which on injection into rats have anti-inflammatory effects should be classified as APRs (table 30.1). Similarly, kininogen, kininogenase, angiotensinogen2 and those constituents of complement which are responsible for reactive lysis must also be considered to be APRs. Greatly increased concentrations of kininogen and kininogenase have recently been detected in the blood of rats after injury3. As shown in figure 30.1, the kininogen and kininogenase concentrations were found to be at a maximum after 2 days, as is typical of many other APRs.


Plasma Protein Acute Phase Protein Acute Phase Response Acute Phase Reactant Liver Slice 
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© The Contributors 1976

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