Albumin transcapillary escape rate as an approach to microvascular physiology in health and disease
Kinetic studies with labelled proteins have been concerned mostly with measurements of metabolic rates and the distribution of plasma proteins between the intravascular and extravascular space. Such studies have contributed considerably to our realisation of the fact that from the synthesis to the disappearance from the body these proteins circulate at individual rates between plasma and interstitial fluid. Much time and effort have been devoted to kinetic models to see how many pools, or rather how many separate rates of exchange between intravascular and extravascular compartments can be distinguished for one individual protein. Since the animal experiments of the Wasserman and Mayerson group1 – 5 there have been few investigations into the nature of the transcapillary escape of endogenous macromolecules and the pathophysiological changes hereof in vascular disease. Most information on the microvascular permeability has been extracted from studies employing small tracer molecules or dextrans.
KeywordsPermeability Filtration Albumin Retina Angiotensin
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- 1.Wasserman, K. and Mayerson, H. S. Exchange of albumin between plasma and lymph. Am. J. Physiol., 165 (1951), 15–26Google Scholar
- 4.Shirley, H. H., Wolfram, C. G., Wasserman, K. and Mayerson, H. S. Capillary permeability to macromolecules: Stretched pore phenomenon. Am. J. Physiol., 190 (1957), 189–193Google Scholar
- 5.Mayerson, H. S., Wolfram, C. G., Shirley, H. H. and Wasserman, K. Regional differences in capillary permeability. Am. J. Physiol., 198 (1960), 155–160Google Scholar
- 11.Lendrum, A. C. The hypertensive diabetic kidney as a model of so called collagen diseases. Canad. Med. Ass. J., 88 (1963), 442–452Google Scholar
- 12.Pappenheimer, J. R., Renkin, E. M. and Cornoero, L. M. Filtration, diffusion and molecular sieving through peripheral capillary membranes. Am. J. Physiol., 167 (1951), 13–46Google Scholar
- 13.Vaerman, J.-P. and Heremans, J. F. Origin and molecular size of immunoglobulin-A in the mesenteric lymph of the dog. Immunology, 18 (1970), 27–38Google Scholar
- 16.Pietra, C. G., D’Amodio, M. D., Leventhal, M. M. Oh, W. and Brando, J. L. Electron microscopy of cutaneous capillaries of newborn infants: Effects of placental transfusion. Pediatrics, 42 (1968), 678–683Google Scholar
- 1.Giese, J. (1966). Pathogenesis of hypertensive vascular disease, Munksgaard, CopenhagenGoogle Scholar
- 2.Reeve, E. B. and Chen, A. Y. (1970). Regulation of Interstitial albumin. In Plasma Protein Metabolism, M. A. Rothschild and T. A. Waldmann, eds., Academic Press, New York, pp. 89–109Google Scholar