Albumin transcapillary escape rate as an approach to microvascular physiology in health and disease
Kinetic studies with labelled proteins have been concerned mostly with measurements of metabolic rates and the distribution of plasma proteins between the intravascular and extravascular space. Such studies have contributed considerably to our realisation of the fact that from the synthesis to the disappearance from the body these proteins circulate at individual rates between plasma and interstitial fluid. Much time and effort have been devoted to kinetic models to see how many pools, or rather how many separate rates of exchange between intravascular and extravascular compartments can be distinguished for one individual protein. Since the animal experiments of the Wasserman and Mayerson group1 – 5 there have been few investigations into the nature of the transcapillary escape of endogenous macromolecules and the pathophysiological changes hereof in vascular disease. Most information on the microvascular permeability has been extracted from studies employing small tracer molecules or dextrans.
KeywordsEssential Hypertension Plasma Volume Acute Hypertension Extravascular Compartment Fractional Catabolic Rate
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