Lipoprotein synthesis in hypoproteinemia of experimental nephrotic syndrome and plasmapheresis

  • E. Shafrir
  • T. Brenner


The nephrotic syndrome is characterised by three salient features: proteinuria, hypoproteinemia and hyperlipoproteinemia. The massive protein loss imposes an extreme compensatory burden on the liver, which has the task of filling a virtually bottomless barrel: most of the newly synthesised protein is promptly excreted in the urine. Epstein in 19171 used the term ‘diabetes albuminuricus’ for nephrosis, because of parallelism to the glucosuria: today we may say that the futile hepatic gluconeogenesis in diabetes, magnifying the spillover of glucose in the urine, seems to represent a more appropriate analogy.


Free Fatty Acid High Density Lipoprotein Lipid Moiety Lipoprotein Synthesis Lipid Radioactivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Epstein, A. A. J. Amer. Med. Ass., 69 (1917), 444CrossRefGoogle Scholar
  2. 2.
    Marsh, J. B. and Drabkin, D. L. Metabolism, 9 (1960), 948Google Scholar
  3. 3.
    Marsh, J. B. and Whereat, A. F. J. Biol. Chem., 234 (1959), 3196Google Scholar
  4. 4.
    Radding, C. M. and Steinberg, D. J. Clin. Invest., 39 (1960), 1560CrossRefGoogle Scholar
  5. 5.
    Bar-on, H. and Shafrir, E. Isr. J. Med. Sci., 1 (1965), 365Google Scholar
  6. 6.
    Rothschild, M. A. and Waldman, T. (1970). In Plasma Protein Metabolism, Academic Press, New York, p. 233Google Scholar
  7. 7.
    Ruderman, N. B., Jones, A. L., Krauss, R. M. and Shafrir, E. J. Clin. Invest., 50 (1971), 1355CrossRefGoogle Scholar
  8. 8.
    Bersot, T. P., Brown, W. V., Levy, R. I., Windmueller, H. G., Fredrickson, D. S. and LeGuire, V. S. Biochemistry, 9 (1970), 3427CrossRefGoogle Scholar
  9. 9.
    Dubach, V., Recant, L., Hatch, F. and Koch, M. Proc. Soc. Exp. Biol. Med., 105 (1960), 392CrossRefGoogle Scholar
  10. 10.
    Gutman, A. and Shafrir, E. Amer. J. Physiol., 205 (1963), 702Google Scholar
  11. 11.
    Tashimo, M. and Matsuda, I. Clin. Chim. Acta, 41 (1972), 67CrossRefGoogle Scholar
  12. 12.
    Shafrir, E., Brenner, T., Gutman, A., Orevi, M., Diamant, S. and Mayer, M. Isr. J. Med. Sci., 8 (1972), 271Google Scholar
  13. 13.
    Shafrir, E., Brenner, T., Gutman, A. and Orevi, M. Amer. J. Physiol., 226 (1974), 162Google Scholar
  14. 14.
    Diamant, S. and Shafrir, E. Biochim. Biophys. Acta., 360 (1974), 241CrossRefGoogle Scholar
  15. 15.
    Mayer, M. and Shafrir, E. Isr. J. Med. Sci., 8 (1972), 859Google Scholar
  16. 16.
    Heyman, W. and Hackel, W. B. Metabolism, 8 (1959), 169Google Scholar
  17. 17.
    Rosenman, R. H., Friedman, M. and Byers, S. O. J. Clin. Invest., 34 (1955), 700CrossRefGoogle Scholar

Copyright information

© The Contributors 1976

Authors and Affiliations

  • E. Shafrir
  • T. Brenner

There are no affiliations available

Personalised recommendations