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Lipoprotein synthesis in hypoproteinemia of experimental nephrotic syndrome and plasmapheresis

  • E. Shafrir
  • T. Brenner

Abstract

The nephrotic syndrome is characterised by three salient features: proteinuria, hypoproteinemia and hyperlipoproteinemia. The massive protein loss imposes an extreme compensatory burden on the liver, which has the task of filling a virtually bottomless barrel: most of the newly synthesised protein is promptly excreted in the urine. Epstein in 19171 used the term ‘diabetes albuminuricus’ for nephrosis, because of parallelism to the glucosuria: today we may say that the futile hepatic gluconeogenesis in diabetes, magnifying the spillover of glucose in the urine, seems to represent a more appropriate analogy.

Keywords

Free Fatty Acid High Density Lipoprotein Lipid Moiety Lipoprotein Synthesis Lipid Radioactivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Contributors 1976

Authors and Affiliations

  • E. Shafrir
  • T. Brenner

There are no affiliations available

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