Abstract
The nephrotic syndrome is characterised by three salient features: proteinuria, hypoproteinemia and hyperlipoproteinemia. The massive protein loss imposes an extreme compensatory burden on the liver, which has the task of filling a virtually bottomless barrel: most of the newly synthesised protein is promptly excreted in the urine. Epstein in 19171 used the term ‘diabetes albuminuricus’ for nephrosis, because of parallelism to the glucosuria: today we may say that the futile hepatic gluconeogenesis in diabetes, magnifying the spillover of glucose in the urine, seems to represent a more appropriate analogy.
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Shafrir, E., Brenner, T. (1976). Lipoprotein synthesis in hypoproteinemia of experimental nephrotic syndrome and plasmapheresis. In: Bianchi, R., Mariani, G., McFarlane, A.S. (eds) Plasma Protein Turnover. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-02644-9_27
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DOI: https://doi.org/10.1007/978-1-349-02644-9_27
Publisher Name: Palgrave Macmillan, London
Print ISBN: 978-1-349-02646-3
Online ISBN: 978-1-349-02644-9
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